IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF- κB Pathway
Psoriasis is a chronic inflammatory skin disease characterized by the activation of keratinocytes and the infiltration of immune cells. Overexpression of the transcription factor LIM-domain only protein 4 (LMO4) promoted by IL-23 has critical roles in regulating the proliferation and differentiation of psoriatic keratinocytes. IL-6, an autocrine cytokine in psoriatic epidermis, is a key mediator of IL-23/T helper 17 –driven cutaneous inflammation. However, little is known about how IL-6 regulates the up-regulation of LMO4 expression in psoriatic lesions. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 3, 2024 Category: Pathology Authors: Zhenzhen Tu, Wei Wei, Fanjun Zeng, Wenwen Wang, Yuyan Zhang, Yintao Zhang, Fusheng Zhou, Chunlin Cai, Siping Zhang, Haisheng Zhou Tags: Regular article Source Type: research
Histologic Evidence of Epithelial –Mesenchymal Transition and Autophagy in Human Fetal Membranes
Preterm, prelabor rupture of the human fetal membranes (pPROM) is involved in 40% of spontaneous preterm births. Cellular-level disturbances and inflammation are effectors of membrane degradation, weakening, and rupture. Maternal risk factors induce oxidative stress (OS), senescence, and senescence-associated inflammation of the fetal membranes as reported mechanisms related to pPROM. Inflammation can also arise in fetal membrane cells (amnion/chorion) due to OS-induced autophagy and epithelial –mesenchymal transition (EMT). (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 3, 2024 Category: Pathology Authors: Mary E. Severino, Lauren S. Richardson, Marian Kacerovsky, Ramkumar Menon Tags: Regular article Source Type: research
Histologic Evidence of Epithelial-Mesenchymal Transition and Autophagy in Human Fetal Membranes
Preterm prelabor rupture of the human fetal membranes (pPROM) is associated with 40% of spontaneous preterm births. Cellular level disturbances and inflammation are effectors of membrane degradation, weakening, and rupture. Maternal risk factors induce oxidative stress (OS), senescence, and senescence-associated inflammation of the fetal membranes as reported mechanisms related to pPROM. Inflammation can also arise in fetal membrane cells (amnion/chorion) due to OS-induced autophagy and epithelial-mesenchymal transition (EMT). (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 3, 2024 Category: Pathology Authors: Mary Elise Severino, Lauren S. Richardson, Marian Kacerovsky, Ramkumar Menon Tags: Regular Article Source Type: research
IL-6 upregulates expression of LMO4 in psoriatic keratinocytes through activation of the MEK/ERK/NF- κB pathway
Psoriasis is a chronic inflammatory skin disease characterized by the activation of keratinocytes and the infiltration of immune cells. Overexpression of the transcription factor LIM-domain only protein 4 (LMO4) promoted by interleukin-23 (IL-23) has critical roles in regulating the proliferation and differentiation of psoriatic keratinocytes. IL-6, an autocrine cytokine in psoriatic epidermis, is a key mediator of IL-23/T helper (Th17)-driven cutaneous inflammation. However, little is known about how IL-6 regulates the upregulation of LMO4 expression in psoriatic lesions. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 3, 2024 Category: Pathology Authors: Zhenzhen Tu, Wei Wei, Fanjun Zeng, Wenwen Wang, Yuyan Zhang, Yintao Zhang, Fusheng Zhou, Chunlin Cai, Siping Zhang, Haisheng Zhou Tags: Regular Article Source Type: research
5-hydroxytryptamine 4 receptor agonist attenuates diabetic enteric neuropathy through inhibition of the RIPK3 pathway
This study aimed to explore the beneficial effects of 5-HT4R agonist on enteric neuropathy in a mouse model of diabetes and the mechanisms underlying these effects. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 2, 2024 Category: Pathology Authors: Yingying Cheng, Yueting Kou, Juan Wang, Yue Wang, Weifang Rong, Hongxiu Han, Guohua Zhang Tags: Regular Article Source Type: research
Bicellular localization of tricellular junctional protein angulin-3/ILDR2 allows detection of podocyte injury.
This study focused on a tricellular junction protein angulin-3 and its localization was analyzed in healthy podocytes as well as in developmental stage and in pathological conditions, using a newly-established monoclonal antibody. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 2, 2024 Category: Pathology Authors: Atsuko Y. Higashi, Akira C. Saito, Tomohito Higashi, Kyoko Furuse, Mikio Furuse, Hideki Chiba, Junichiro J. Kazama Tags: Regular Article Source Type: research
PDGF-D is dispensable for the development and progression of murine Alport syndrome
Alport syndrome is an inherited kidney disease, which can lead to glomerulosclerosis and fibrosis, and end-stage kidney disease in children and adults. Platelet-derived growth factor (PDGF)-D was shown to mediate glomerulosclerosis and interstitial fibrosis in different models of kidney disease, prompting us to investigate its role in a murine model of Alport syndrome.In vitro, PDGF-D induced proliferation and profibrotic activation of conditionally immortalized human parietal epithelial cells (ciPECs). (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 1, 2024 Category: Pathology Authors: Emilia Anouk Margo Firat, Eva Miriam Buhl, Nassim Bouteldja, Bart Smeets, Ulf Eriksson, Peter Boor, Barbara Mara Klinkhammer Tags: Regular Article Source Type: research
Diabetes Accelerates Steatohepatitis in Mice
This study investigated the impact of diabetes on steatohepatitis and established a novel mouse model for diabetic steatohepatitis. Male C57BL/6J mice were fed a 60% high-fat diet (HFD) and injected with carbon tetrachloride (CCl4) and streptozotocin (STZ) to induce diabetes. The HFD+CCl4+STZ group showed more severe liver steatosis, hepatocyte ballooning, and regenerative nodules compared with other groups. (Source: American Journal of Pathology)
Source: American Journal of Pathology - January 31, 2024 Category: Pathology Authors: Tuerdiguli Abuduyimiti, Hisanori Goto, Kumi Kimura, Yu Oshima, Ryota Tanida, Kyoko Kamoshita, Nontaphat Leerach, Halimulati Abuduwaili, Hein Ko Oo, Qifang Li, Cynthia M. Galicia-Medina, Hiroaki Takayama, Kiyo-aki Ishii, Yujiro Nakano, Yumie Takeshita, Tom Tags: Regular article Source Type: research
Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease
Neutrophils are an important cell type often considered the body's "first responder" in the response to inflammatory insult or damage. They are recruited to the tissue of the lungs during inflammatory airspace diseases and can perform unique and complex functions that range from helpful to harmful. Additionally, neutrophil function is unique in the lungs through heterogeneity of the inflammatory cascade and retention in the vasculature. They are known to "marginate" or remain stagnant in the lungs even during non-disease conditions. (Source: American Journal of Pathology)
Source: American Journal of Pathology - January 31, 2024 Category: Pathology Authors: Maureen E. Haynes, David P. Sullivan, William A. Muller Tags: Mini-Review Source Type: research
Diabetes accelerates steatohepatitis in mice: liver pathology and single-cell gene expression signatures
Glucose lowering independently reduces liver fibrosis in human NAFLD. We investigated the impact of diabetes on steatohepatitis and established a novel mouse model for diabetic steatohepatitis.Male C57BL/6J mice were fed a 60% high-fat diet (HFD) and injected with carbon tetrachloride (CCl4) and streptozotocin (STZ) to induce diabetes. The HFD+CCl4+STZ group displayed more severe liver steatosis, hepatocyte ballooning, and regenerative nodules compared to other groups. Diabetes upregulated inflammatory cytokine-associated genes and elevated the M1/M2 macrophage ratios in the liver. (Source: American Journal of Pathology)
Source: American Journal of Pathology - January 31, 2024 Category: Pathology Authors: Tuerdiguli Abuduyimiti, Hisanori Goto, Kumi Kimura, Yu Oshima, Ryota Tanida, Kyoko Kamoshita, Nontaphat Leerach, Halimulati Abuduwaili, Hein Ko Oo, Qifang Li, Cynthia M. Galicia-Medina, Hiroaki Takayama, Kiyo-aki Ishii, Yujiro Nakano, Yumie Takeshita, Tom Tags: Regular Article Source Type: research
Omics Approaches Unveiling the Biology of Human Atherosclerotic Plaques
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the buildup of plaques with the accumulation and transformation of lipids, immune cells, vascular smooth muscle cells, and necrotic cell debris. Plaques with collagen-poor thin fibrous caps infiltrated by macrophages and lymphocytes are considered unstable because they are at the greatest risk of rupture and clinical events. However, the current histological definition of plaque types may not fully capture the complex molecular nature of atherosclerotic plaque biology and the underlying mechanisms contributing to plaque progression, ru...
Source: American Journal of Pathology - January 24, 2024 Category: Pathology Authors: Xun Wu, Hanrui Zhang Tags: Review Source Type: research
Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice
Sleep deprivation (SD) is a global public health burden, and has a detrimental role in the nervous system. Retina is an important part of the central nervous system; however, whether SD affects retinal structures and functions remains largely unknown. Herein, chronic SD mouse model indicated that loss of sleep for 4 months could result in reductions in the visual functions, but without obvious morphologic changes of the retina. Ultrastructural analysis by transmission electron microscope revealed the deterioration of mitochondria, which was accompanied with the decrease of multiple mitochondrial proteins in the retina. (So...
Source: American Journal of Pathology - January 19, 2024 Category: Pathology Authors: Liying Tang, Houjian Zhang, Yi Liao, Shengmei Zhou, Yaqiong Yang, Mouxin Zhang, Yuli Guo, Tingyu Xie, Shikun Chen, Weijie Ouyang, Xiang Lin, Shaopan Wang, Caihong Huang, Minjie Zhang, Jingbin Zhuang, Jiankai Zhao, Rongrong Zhang, Changjun Zhang, Zibing Ji Tags: Regular article Source Type: research
Macrophage Activation in Synovitis and Osteoarthritis of Temporomandibular Joint and Its Relationship with the Progression of Synovitis and Bone Remodeling
This study investigates the regulatory mechanisms of synovial macrophages and their polarization in the progression of temporomandibular joint osteoarthritis (TMJOA). Macrophage depletion models were established by intra-articular injection of clodronate liposomes and unloaded liposomes. TMJOA was induced by intra-articular injection of 50 μL Complete Freund's Adjuvant and the surgery of disc perforation. The contralateral joint was used as the control group. The expression of F4/80, CD86, and CD206 in the synovium was detected by immunofluorescence staining analysis. (Source: American Journal of Pathology)
Source: American Journal of Pathology - January 19, 2024 Category: Pathology Authors: Shiyu Hu, Huimin Li, Henghua Jiang, Xin Liu, Jin Ke, Xing Long Tags: Regular article Source Type: research
Correction
The authors of the article entitled, “Hyperglycemia Promotes Mitophagy and Thereby Mitigates Hyperglycemia-Induced Damage” (Volume 192, pages 1779–1794 of the December 2022 issue of The American Journal of Pathology; DOI: https://doi.org/10.1016/j.ajpath.2022.08.004) have requested a correction to update the funding statement for this article to include the Retina Research Foundation. (Source: American Journal of Pathology)
Source: American Journal of Pathology - January 19, 2024 Category: Pathology Tags: Correction Source Type: research
Editorial Board
(Source: American Journal of Pathology)
Source: American Journal of Pathology - January 19, 2024 Category: Pathology Source Type: research
