Histologic Evidence of Epithelial-Mesenchymal Transition and Autophagy in Human Fetal Membranes

Preterm prelabor rupture of the human fetal membranes (pPROM) is associated with 40% of spontaneous preterm births. Cellular level disturbances and inflammation are effectors of membrane degradation, weakening, and rupture. Maternal risk factors induce oxidative stress (OS), senescence, and senescence-associated inflammation of the fetal membranes as reported mechanisms related to pPROM. Inflammation can also arise in fetal membrane cells (amnion/chorion) due to OS-induced autophagy and epithelial-mesenchymal transition (EMT).

Source: American Journal of Pathology - February 3, 2024 Category: Pathology Authors: Mary Elise Severino, Lauren S. Richardson, Marian Kacerovsky, Ramkumar Menon Tags: Regular Article Source Type: research