Diabetes Accelerates Steatohepatitis in Mice

This study investigated the impact of diabetes on steatohepatitis and established a novel mouse model for diabetic steatohepatitis. Male C57BL/6J mice were fed a 60% high-fat diet (HFD) and injected with carbon tetrachloride (CCl4) and streptozotocin (STZ) to induce diabetes. The HFD+CCl4+STZ group showed more severe liver steatosis, hepatocyte ballooning, and regenerative nodules compared with other groups.

Source: American Journal of Pathology - January 31, 2024 Category: Pathology Authors: Tuerdiguli Abuduyimiti, Hisanori Goto, Kumi Kimura, Yu Oshima, Ryota Tanida, Kyoko Kamoshita, Nontaphat Leerach, Halimulati Abuduwaili, Hein Ko Oo, Qifang Li, Cynthia M. Galicia-Medina, Hiroaki Takayama, Kiyo-aki Ishii, Yujiro Nakano, Yumie Takeshita, Tom Tags: Regular article Source Type: research