IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF- κB Pathway

Psoriasis is a chronic inflammatory skin disease characterized by the activation of keratinocytes and the infiltration of immune cells. Overexpression of the transcription factor LIM-domain only protein 4 (LMO4) promoted by IL-23 has critical roles in regulating the proliferation and differentiation of psoriatic keratinocytes. IL-6, an autocrine cytokine in psoriatic epidermis, is a key mediator of IL-23/T helper 17 –driven cutaneous inflammation. However, little is known about how IL-6 regulates the up-regulation of LMO4 expression in psoriatic lesions.

Source: American Journal of Pathology - February 3, 2024 Category: Pathology Authors: Zhenzhen Tu, Wei Wei, Fanjun Zeng, Wenwen Wang, Yuyan Zhang, Yintao Zhang, Fusheng Zhou, Chunlin Cai, Siping Zhang, Haisheng Zhou Tags: Regular article Source Type: research