Increased Matrix Metalloproteinase-1 Activation Enhances Disruption and Regression of k-RasV12 –Expressing Arteriovenous Malformation-Like Vessels
This study sought to identify potential mechanisms by which k-RasV12 –expressing endothelial cell (EC) tubes demonstrate an increased propensity to regress compared with controls. Activated k-Ras mutations play a role in a variety of pathological conditions, including arteriovenous malformations, which are prone to bleed, causing serious hemorrhagic complications. Previously, the authors reported that ECs expressing active k-RasV12 demonstrate markedly excessive lumen formation with widened and shortened tubes accompanied by reduced pericyte recruitment and basement membrane deposition, leading to deficient capillary net...
Source: American Journal of Pathology - June 14, 2023 Category: Pathology Authors: Zheying Sun, Prisca K. Lin, Ksenia Yrigoin, Scott S. Kemp, George E. Davis Tags: Regular article Source Type: research
Increased matrix metalloproteinase-1 activation enhances disruption and regression of k-RasV12-expressing arteriovenous malformation-like vessels
In this study, we sought to identify potential mechanisms by which k-RasV12 expressing EC tubes demonstrate an increased propensity to regress compared to controls. Activated k-Ras mutations play a role in a variety of pathological conditions, including arteriovenous malformations (AVMs), which are prone to bleed causing serious hemorrhagic complications. Previously, we reported that ECs expressing active k-RasV12 demonstrate markedly excessive lumen formation with widened and shortened tubes accompanied by reduced pericyte recruitment and basement membrane deposition, leading to deficient capillary network assembly. (Sour...
Source: American Journal of Pathology - June 14, 2023 Category: Pathology Authors: Zheying Sun, Prisca K. Lin, Ksenia Yrigoin, Scott S. Kemp, George E. Davis Tags: Regular Article Source Type: research
Inhibition of ErbB3 and Associated Regulatory Pathways Potently Impairs Malignant Peripheral Nerve Sheath Tumor Proliferation and Survival
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, currently untreatable Schwann cell-derived neoplasms with hyperactive MAPK and mTOR signaling pathways. To identify potential therapeutic targets, we previously performed genome-scale shRNA screens that implicated the neuregulin-1 (NRG1) receptor erbB3 in MPNST proliferation and/or survival. Here, we show that erbB3 is commonly expressed in MPNSTs and MPNST cell lines and that erbB3 knockdown inhibits MPNST proliferation and survival. (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 14, 2023 Category: Pathology Authors: Laurel E. Black, Jody Fromm Longo, Joshua C. Anderson, Steven L. Carroll Tags: Regular Article Source Type: research
Fibrotic matrix induces mesenchymal transformation of epithelial cells in oral submucous fibrosis
Oral submucous fibrosis (OSF) is a potentially malignant disorder of the oral mucosa; however, whether and how the fibrotic matrix of OSF is involved in the malignant transformation of epithelial cells remains unknown. Herein, oral mucosa tissue from patients with OSF, OSF rat models, and their controls were used to observe the extracellular matrix changes and epithelial-mesenchymal transformation (EMT) in fibrotic lesions. Compared with the controls, oral mucous tissues from patients with OSF exhibited increased number of myofibroblasts, decreased number of blood vessels and increased type I and type III collagen levels. ...
Source: American Journal of Pathology - June 13, 2023 Category: Pathology Authors: Hao-qing Xu, Zhen-xing Guo, Jian-fei Yan, Shu-yan Wang, Jia-lu Gao, Xiao-xiao Han, Wen-pin Qin, Wei-cheng Lu, Chang-he Gao, Wei-wei Zhu, Yu-tong Fu, Kai Jiao Tags: Regular Article Source Type: research
This Month in AJP
The molecular modifications occurring at the tonsillar tissues associated with lymphatic spread are critical in anti-tumor immune response as well as disease progression in oropharyngeal carcinomas (OPCs). By gene expression profiling of peri-tumoral lymphoid regions, Wakisaka et al (Am J Pathol, AJPA-D-23-00009) explored the unique microenvironment of secondary lymphoid organs involved in OPC. The analysis identified transcriptional programs associated with metastasis as well as potential patterns of anti-tumor immune response, and may aid in patient stratification for treatments. (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 13, 2023 Category: Pathology Tags: This Month in AJP Source Type: research
The Oncogenic Protein Kinase/ATPase RIOK1 Is Up-Regulated via the c-myc/E2F Transcription Factor Axis in Prostate Cancer
In this study, the expression, regulation, and therapeutic potential of RIOK1 in PCa were examined. (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 8, 2023 Category: Pathology Authors: Florian Handle, Martin Puhr, Martina Gruber, Chiara Andolfi, Georg Sch äfer, Helmut Klocker, Johannes Haybaeck, Peter De Wulf, Zoran Culig Tags: Regular article Source Type: research
Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis
Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathologic type of cancer with a high recurrence rate and the biological features of invasion and metastasis. On the basis of previous spatial transcriptome studies, our team found extensive metabolic reprogramming in IMPC, which contributes to tumor cell heterogeneity. However, the impact of metabolome alterations on IMPC biological behavior is unclear. We performed endogenous metabolite-targeted metabolomic analysis on frozen tumor tissue samples from 25 patients with breast IMPC and 34 patients with invasive ductal carcinoma not otherwise specified...
Source: American Journal of Pathology - June 8, 2023 Category: Pathology Authors: Kailiang Wu, Weidong Li, Hanjiao Liu, Chen Niu, Qianqian Shi, Jingyue Zhang, Guangshen Gao, Hui Sun, Fangfang Liu, Li Fu Tags: Regular article Source Type: research
Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathological type of cancer with a high recurrence rate and the biological features of invasion and metastasis. Based on previous spatial transcriptome studies, our team found extensive metabolic reprogramming in IMPC, which contributes to tumor cell heterogeneity. However, the impact of metabolome alterations on IMPC biological behavior is unclear. We performed endogenous metabolite-targeted metabolomic analysis on frozen tumor tissue samples from 25 patients with breast IMPC and 34 patients with invasive ductal carcinoma not otherwise specified (IDC...
Source: American Journal of Pathology - June 8, 2023 Category: Pathology Authors: Kailiang Wu, Weidong Li, Hanjiao Liu, Chen Niu, Qianqian Shi, Jingyue Zhang, Guangshen Gao, Hui Sun, Fangfang Liu, Li Fu Tags: Regular Article Source Type: research
The oncogenic protein kinase/ATPase RIOK1 is up-regulated via the MYC/E2F transcription factor axis in prostate cancer
In this study, we examined the expression, regulation and therapeutic potential of RIOK1 in PCa. RIOK1 mRNA and protein expression were elevated in PCa tissue samples and correlated with proliferative and protein homeostasis related pathways. (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 8, 2023 Category: Pathology Authors: Florian Handle, Martin Puhr, Martina Gruber, Chiara Andolfi, Georg Sch äfer, Helmut Klocker, Johannes Haybaeck, Peter De Wulf, Zoran Culig Tags: Regular Article Source Type: research
FBXO22 mediates the NGF/TRKA signaling pathway in bone metastases in prostate cancer
This study aims to explore the biological function of E3 ubiquitin ligase F-box only protein 22 (FBXO22) in PC metastasis and its specific regulation mechanism. It was revealed by transcriptome sequencing that FBXO22 was overexpressed in PC tissues (versus adjacent tissues) and bone tissues (versus biopsied bone tissues without bone metastases). (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 8, 2023 Category: Pathology Authors: Yuehua Zhang, Wen Li, Shenghu Guo, Zheng Wu, Lei Zhang, Ya Liu, Xing Li, Xiaojin Guo, Jing Cao, Chunwang Yang, Zhiyu Wang Tags: Regular Article Source Type: research
Exploring the Vital Link Between Glioma, Neuron, and Neural Activity in the Context of Invasion
Because of their ability to infiltrate normal brain tissue, gliomas frequently evade microscopic surgical excision. The histologic infiltrative property of human glioma has been previously characterized as Scherer secondary structures, of which the perivascular satellitosis is a prospective target for anti-angiogenic treatment in high-grade gliomas. However, the mechanisms underlying perineuronal satellitosis remain unclear, and therapy remains lacking. Our knowledge of the mechanism underlying Scherer secondary structures has improved over time. (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 1, 2023 Category: Pathology Authors: Masafumi Miyai, Toru Iwama, Akira Hara, Hiroyuki Tomita Tags: Review Source Type: research
Correction
The authors of the article entitled, “Two Distinct Tumorigenic Processes in Endometrial Endometrioid Adenocarcinoma” (Volume 190, pages 234–251 of the January 2020 issue of The American Journal of Pathology; DOI: https://doi.org/10.1016/j.ajpath.2019.09.022) have discovered incorrect descriptions in the Materials and Methods rega rding the presence or absence of atypia lesions within endometrial hyperplasia (EH), and the inclusion of the atypia lesions in the genomic assays. The changes to these descriptions do not impact the data or conclusions originally presented in the published manuscript (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 1, 2023 Category: Pathology Tags: Correction Source Type: research
Correction
The authors of the article entitled, “Vitamin D and Calcium Supplementation Accelerates Randall's Plaque Formation in a Murine Model” (Volume 189, pages 2171–2180 of the November 2019 issue of The American Journal of Pathology; DOI: https://doi.org/10.1016/j.ajpath.2019.07.013) have discovered an error in the dose of vitamin D i ndexed to weight as presented in the Animal Studies section of the Materials and Methods. The authors confirm that this update does not impact the conclusions presented in the manuscript. (Source: American Journal of Pathology)
Source: American Journal of Pathology - June 1, 2023 Category: Pathology Tags: Correction Source Type: research
Editorial Board
(Source: American Journal of Pathology)
Source: American Journal of Pathology - June 1, 2023 Category: Pathology Source Type: research
Table of Contents
(Source: American Journal of Pathology)
Source: American Journal of Pathology - June 1, 2023 Category: Pathology Source Type: research
