Inhibition of ErbB3 and Associated Regulatory Pathways Potently Impairs Malignant Peripheral Nerve Sheath Tumor Proliferation and Survival

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, currently untreatable Schwann cell-derived neoplasms with hyperactive MAPK and mTOR signaling pathways. To identify potential therapeutic targets, we previously performed genome-scale shRNA screens that implicated the neuregulin-1 (NRG1) receptor erbB3 in MPNST proliferation and/or survival. Here, we show that erbB3 is commonly expressed in MPNSTs and MPNST cell lines and that erbB3 knockdown inhibits MPNST proliferation and survival.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research