Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis

Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathologic type of cancer with a high recurrence rate and the biological features of invasion and metastasis. On the basis of previous spatial transcriptome studies, our team found extensive metabolic reprogramming in IMPC, which contributes to tumor cell heterogeneity. However, the impact of metabolome alterations on IMPC biological behavior is unclear. We performed endogenous metabolite-targeted metabolomic analysis on frozen tumor tissue samples from 25 patients with breast IMPC and 34 patients with invasive ductal carcinoma not otherwise specified (IDC-NOS) by liquid chromatography –mass spectrometry.

Source: American Journal of Pathology - June 8, 2023 Category: Pathology Authors: Kailiang Wu, Weidong Li, Hanjiao Liu, Chen Niu, Qianqian Shi, Jingyue Zhang, Guangshen Gao, Hui Sun, Fangfang Liu, Li Fu Tags: Regular article Source Type: research