Increased Matrix Metalloproteinase-1 Activation Enhances Disruption and Regression of k-RasV12 –Expressing Arteriovenous Malformation-Like Vessels

This study sought to identify potential mechanisms by which k-RasV12 –expressing endothelial cell (EC) tubes demonstrate an increased propensity to regress compared with controls. Activated k-Ras mutations play a role in a variety of pathological conditions, including arteriovenous malformations, which are prone to bleed, causing serious hemorrhagic complications. Previously, the authors reported that ECs expressing active k-RasV12 demonstrate markedly excessive lumen formation with widened and shortened tubes accompanied by reduced pericyte recruitment and basement membrane deposition, leading to deficient capillary network assembly.

Source: American Journal of Pathology - June 14, 2023 Category: Pathology Authors: Zheying Sun, Prisca K. Lin, Ksenia Yrigoin, Scott S. Kemp, George E. Davis Tags: Regular article Source Type: research