Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis

Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathological type of cancer with a high recurrence rate and the biological features of invasion and metastasis. Based on previous spatial transcriptome studies, our team found extensive metabolic reprogramming in IMPC, which contributes to tumor cell heterogeneity. However, the impact of metabolome alterations on IMPC biological behavior is unclear. We performed endogenous metabolite-targeted metabolomic analysis on frozen tumor tissue samples from 25 patients with breast IMPC and 34 patients with invasive ductal carcinoma not otherwise specified (IDC-NOS) by liquid chromatography –mass spectrometry (LC–MS).
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research