Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice

Macrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1 β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bil e duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced liver injury by reducing the oxidative stress (OS)-induced inflammatory reaction in macrophages.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research