Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease

Alcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacological options. The goal of the current study was to investigate the efficacy of pharmacological inhibition of soluble epoxide hydrolase (sEH, an enzyme involved in lipid metabolism) in experimental ALD and to examine the underlying mechanisms. C57BL/6J male mice underwent acute-on-chronic ethanol (EtOH) feeding with or without the sEH inhibitor, TUCB. Liver injury was assessed by multiple end-points.

Source: American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Jeffrey B. Warner, Josiah E. Hardesty, Ying L. Song, Alison T. Floyd, Zhongbin Deng, Audriy Jebet, Liqing He, Xiang Zhang, Craig J. McClain, Bruce D. Hammock, Dennis R. Warner, Irina A. Kirpich Tags: Regular Article Source Type: research