Release of miR-29 target laminin C2 improves skin repair

MicroRNAs (miRs) are small non-coding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in mouse and human skin where it may regulate functions important for skin repair. Cutaneous wound healing model in miR29ab1 knockout (KO) mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis in vitro by autocrine and paracrine mechanisms.

Source: American Journal of Pathology - November 17, 2023 Category: Pathology Authors: Connor James Robinson, Lalitha Thiagarajan, Rebecca Maynard, Maneesha Aruketty, Jeremy Herrera, Lewis Dingle, Adam Reid, Jason Wong, Heng Cao, James Dooley, Adrian Liston, Daniela M üllhaupt, Paul Hiebert, Hayley Hiebert, Svitlana Kurinna Tags: Regular Article Source Type: research