Surface modification of polyurethane with eptifibatide-loaded degradable nanoparticles reducing risk of blood coagulation
Publication date: Available online 13 February 2021Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Katarzyna Reczyńska, Roman Major, Magdalena Kopernik, Elżbieta Pamuła, Gabriela Imbir, Hanna Plutecka, Franz Bruckert, Marcin Surmiak (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 15, 2021 Category: Biochemistry Source Type: research
Prevalence, clinical determinants and prognostic implications of coronary procedural complications of percutaneous coronary intervention in non-ST-segment elevation myocardial infarction: Insights from the contemporary multinational TAO trial.
CONCLUSIONS: In a contemporary NSTE ACS population, procedural complications with PCI remain frequent, are difficult to predict based on clinical characteristics, and are associated with worse ischaemic and haemorrhagic outcomes.
PMID: 33518473 [PubMed - as supplied by publisher] (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - January 28, 2021 Category: Cardiology Authors: Abtan J, Wiviott SD, Sorbets E, Popovic B, Elbez Y, Mehta SR, Sabatine MS, Bode C, Pollack CV, Cohen M, Moccetti T, Laanmets P, Faxon D, Okreglicki A, Ducrocq G, Steg PG, TAO investigators Tags: Arch Cardiovasc Dis Source Type: research
Adjunctive treatment with low dose intra-arterial eptifibatide and intravenous aspirin during carotid stenting: A case series
Publication date: February 2021Source: Journal of Clinical Neuroscience, Volume 84Author(s): Anat Horev, Yair Zlotnik, Vladimir Borodetsky, Ron Biederko, Michael Star, Vladislav Zvenigorodsky, Ilan Shelef, Gal Ifergane (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - December 29, 2020 Category: Neuroscience Source Type: research
[ASAP] An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.0c00490 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 22, 2020 Category: Chemistry Authors: Giuseppina Sabatino, Annunziata D ’Ercole, Lorenzo Pacini, Matteo Zini, Arianna Ribecai, Alfredo Paio, Paolo Rovero, and Anna Maria Papini Source Type: research
Efficacy and Safety of Abbreviated Eptifibatide Treatment in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
In patients with ST-segment elevation myocardial infarction (STEMI), antithrombotic therapy with aspirin, a P2Y12 inhibitor, and heparin is essential to reduce coronary thrombus burden, and to facilitate primary percutaneous coronary intervention (PCI).1,2 In case of periinterventional thrombotic complications, additional use of a glycoprotein IIb/IIIa inhibitor (GPI) is a reasonable bailout treatment.1,2 Eptifibatide is a potent GPI3 that rapidly inhibits platelet aggregation when administered as bolus followed by infusion for 18-24 hours,4 which reduced ischemic endpoints and death in patients undergoing PCI in clinical ...
Source: The American Journal of Cardiology - October 12, 2020 Category: Cardiology Authors: Florian Fischer, Samriddhi Buxy, David J. Kurz, Franz R. Eberli, Oliver Senn, Rainer Zbinden, Ulrike Held, Matthias R. Meyer Source Type: research
There is no difference in safety and efficacy with Tirofiban or Eptifibatide for patients undergoing treatment of large vessel occlusion and underlying intracranial atherosclerosis
Publication date: March 2021Source: Interdisciplinary Neurosurgery, Volume 23Author(s): Hari Movva, Rani Rabah, Wondwossen Tekle, Alexandros Georgiadis, Laurie Preston, Hari Kotta, Ameer E. Hassan (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - October 7, 2020 Category: Neurosurgery Source Type: research
Eptifibatide use following emergent carotid stenting in acute anterior circulation ischemic stroke with tandem occlusion
Early revascularization of the extracranial internal carotid artery in acute anterior circulation ischemic stroke (ACIS) is feasible and may improve clinical outcome. When a stent is deployed, antithrombotic agents should be administered peri-procedurally to ensure stent patency. Our institution implemented a protocol for the use of eptifibatide as a means of maintaining stent patency in the treatment of ACIS associated with cervical internal carotid artery occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Nicholas D Osteraas, Richard W Crowley, Nicholas Panos, Rima M Dafer Source Type: research
Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach
The rapidly spreading, highly contagious and pathogenic SARS-coronavirus 2 (SARS-CoV-2) associated Coronavirus Disease 2019 (COVID-19) has been declared as a pandemic by the World Health Organization (WHO). The novel 2019 SARS-CoV-2 enters the host cell by binding of the viral surface spike glycoprotein (S-protein) to cellular angiotensin converting enzyme 2 (ACE2) receptor. The virus specific molecular interaction with the host cell represents a promising therapeutic target for identifying SARS-CoV-2 antiviral drugs. The repurposing of drugs can provide a rapid and potential cure toward exponentially expanding COVID-19. T...
Source: Frontiers in Immunology - July 9, 2020 Category: Allergy & Immunology Source Type: research
Antiplatelet agents'-ticagrelol and eptifibatide-safety in experimental colitis in mice.
CONCLUSION: The antiplatelet agents ticagrelor and eptifibatide were safe in DSS colitis mice, suggesting their potential in humans suffering from ulcerative colitis, and supporting future safety studies.
PMID: 32721916 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 31, 2020 Category: Gastroenterology Authors: Petrovic SS, Vasiljevska MM, Obradovic SD, Tarabar DK, Doder RB, Majstorovic IJ, Petrovic MD, Magic ZM, Cikota BM, Perisic NJ, Brcerevic IA, Manojlovic NS, Rancic NK Tags: Turk J Gastroenterol Source Type: research
Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection.
In conclusion, the discovery of antiviral molecules targeting capsid protease demystifies the alphavirus capsid protease as a potential target for antiviral drug discovery.
PMID: 32380148 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - May 3, 2020 Category: Virology Authors: Fatma B, Kumar R, Singh VA, Nehul S, Sharma R, Kesari P, Kuhn RJ, Tomar S Tags: Antiviral Res Source Type: research
Eptifibatide
(Source: Reactions Weekly)
Source: Reactions Weekly - March 31, 2020 Category: Drugs & Pharmacology Source Type: research
Novel Antiplatelet Perioperative Bridging Protocol for Lung Lobectomy: A Case Report.
We describe the novel addition of ticagrelor (a short-acting oral antiplatelet agent) to eptifibatide (a short-acting intravenous antiplatelet agent) to bridge DAPT for surgery.
DISCUSSION: This ticagrelor-eptifibatide perioperative bridge resulted in decreased preoperative hospitalization compared with eptifibatide alone. There were no associated perioperative cardiac or bleeding complications.
PMID: 31926566 [PubMed - in process] (Source: The Permanente journal)
Source: The Permanente journal - January 14, 2020 Category: General Medicine Tags: Perm J Source Type: research
Stent-Retriever Thrombectomy Through An Occluded Pipeline Embolization Device
Publication date: Available online 27 December 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Robert Starling, Mohamed Abouelleil, Jefferson Miley, Andrew P. CarlsonAbstractA 71-year-old female with a history of a right medial paraclinoid aneurysm was treated with pipeline embolization device and placed on dual antiplatelet therapy for 6 months. Clopidogrel was discontinued at 6 months, and the patient developed dysarthria, left-hemiplegia, and left-sided facial droop two days later. A CT angiogram demonstrated thrombus formation in the pipeline embolization device resulting in complete carotid occlusion. She present...
Source: Interdisciplinary Neurosurgery - December 29, 2019 Category: Neurosurgery Source Type: research
Routine Glycoprotein IIb/IIIa Inhibitor Therapy in ST-Segment Elevation Myocardial Infarction: A Meta-analysis
ConclusionsRoutine GPI administration in STEMI resulted in a reduction in mortality, driven by reductions in recurrent ischemic events—however predominantly in pre-prasugrel/ticagrelor trials. Trials with contemporary STEMI management are needed to confirm these findings.RésuméContexteLes lignes directrices recommandent le traitement d’appoint par des inhibiteurs des glycoprotéines IIb-IIIa (IGP) uniquement chez certains patients ayant subi un infarctus du myocarde avec élévation du segment ST (STEMI) aigu. Cette étude visait à évaluer l’utilisation systématique des IGP chez les patients ayant subi un STEMI ...
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research
Co-administration of iloprost and eptifibatide in septic shock (CO-ILEPSS) —a randomised, controlled, double-blind investigator-initiated trial investigating safety and efficacy
Part of the pathophysiology in septic shock is a progressive activation of the endothelium and platelets leading to widespread microvascular injury with capillary leakage, microthrombi and consumption coagulop... (Source: Critical Care)
Source: Critical Care - September 5, 2019 Category: Intensive Care Authors: Rasmus Ehrenfried Berthelsen, Sisse Rye Ostrowski, Morten Heiberg Bestle and Per Ingemar Johansson Tags: Research Source Type: research
