Platelets Stimulate Programmed Death-Ligand 1 Expression by Cancer Cells: Inhibition by Anti-Platelet Drugs
CONCLUSIONS: As platelets promote immunoevasion of the adaptive immune response by increasing cancer cell PD-L1 expression and as anti-platelet drugs prevent this immunoevasive response, the investigation of anti-platelet drugs as adjuvant therapy to immune checkpoint inhibitors may be warranted in the treatment of cancer.PMID:34333838 | DOI:10.1111/jth.15478 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - August 1, 2021 Category: Hematology Authors: Amir Asgari Gabriela Lesyk Erika Poitras Natasha Govindasamy Kara Terry Rachel To Valentina Back Jan K Rudzinski John D Lewis Paul Jurasz Source Type: research
