Safety and efficacy of eptifibatide in acute ischemic stroke requiring extracranial carotid artery stenting
CONCLUSIONS: Eptifibatide may have a role in the management of acute stroke requiring carotid stenting. Caution may be required in those with established infarct on presentation imaging.PMID:37574792 | DOI:10.1177/15910199231193928 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - August 14, 2023 Category: Radiology Authors: Michael J Waters Jan Vargas Aquilla Turk Imran Chaudry Raymond D Turner Source Type: research
Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy
CONCLUSIONS: Addition of glenzocimab to aspirin and ticagrelor enhances platelet inhibition via multiple mechanisms of atherothrombosis. Compared to a GPIIb/IIIa inhibitor, glenzocimab shares multiple antithrombotic effects, with less inhibition of mechanisms involved in general haemostasis.PMID:37541591 | DOI:10.1016/j.jtha.2023.07.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - August 4, 2023 Category: Hematology Authors: Fawaz O Alenazy Maan H Harbi Dean P Kavanagh Joshua Price Paul Brady Oscar Hargreaves Paul Harrison Alexandre Slater Alok Tiwari Phillip L R Nicolson Derek L Connolly Paulus Kirchhof Neena Kalia Martine Jandrot-Perrus Pierre H Mangin Steve P Watson Mark R Source Type: research
Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy
CONCLUSIONS: Addition of glenzocimab to aspirin and ticagrelor enhances platelet inhibition via multiple mechanisms of atherothrombosis. Compared to a GPIIb/IIIa inhibitor, glenzocimab shares multiple antithrombotic effects, with less inhibition of mechanisms involved in general haemostasis.PMID:37541591 | DOI:10.1016/j.jtha.2023.07.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - August 4, 2023 Category: Hematology Authors: Fawaz O Alenazy Maan H Harbi Dean P Kavanagh Joshua Price Paul Brady Oscar Hargreaves Paul Harrison Alexandre Slater Alok Tiwari Phillip L R Nicolson Derek L Connolly Paulus Kirchhof Neena Kalia Martine Jandrot-Perrus Pierre H Mangin Steve P Watson Mark R Source Type: research
O-015 The safety and efficacy of cangrelor use in endovascular thrombectomy compared with glycoprotein IIb/IIIa inhibitors
ConclusionCangrelor use was associated with a decreased risk of hemorrhagic conversion and may lead to favorable functional outcomes for patients during hospitalization when compared to GPI use. Future prospective studies are warranted to investigate its use in EVT.Disclosures A. Devarajan: None. S. Gottiparthi: None. J. Zhang: None. D. Goldman: None. A. Schupper: None. C. Rossitto: None. J. Scaggiante: None. M. Al-Kawaz: None. B. Kim: None. N. Musallam: None. N. Davis: None. K. Wu: None. A. Ouf: None. D. Klavansky: None. S. Majidi: None. J. Liang: None. T. Shigematsu: None. J. Mocco: None. J. Fifi: None. H. Shoirah: None....
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Devarajan, A., Gottiparthi, S., Zhang, J., Goldman, D., Schupper, A., Rossitto, C., Scaggiante, J., Al-Kawaz, M., Kim, B., Musallam, N., Davis, N., Wu, K., Ouf, A., Klavansky, D., Majidi, S., Liang, J., Shigematsu, T., Mocco, J., Fifi, J., Shoirah, H. Tags: SNIS 20th annual meeting oral abstracts Source Type: research
E-008 Safety and efficacy of eptifibatide in acute ischemic stroke requiring extracranial carotid artery stenting
ConclusionsEptifibatide may have a role in the management of acute stroke requiring carotid stenting. Caution may be required in those with established infarct on presentation imaging.Disclosures M. Waters: None. J. Vargas: None. R. Turner: None. A. Turk: None. I. Chaudry: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Waters, M., Vargas, J., Turner, R., Turk, A., Chaudry, I. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-014 Stent-assisted coiling for treatment of acutely ruptured cerebral aneurysm
ConclusionSAC is an effective and feasible procedure for acutely ruptured aneurysm. Despite relatively high ischemic complication, favorable outcome could be achieved in majority of patients even in patients with high grade SAH. Usage of Dual antiplatelets in these patients could increase hemorrhagic complications of neurosurgical procedures.Disclosures H. Baharvahdat: None. F. Qoorchi Moheb Seraj: None. M. Vaezi: None. F. Ebrahimnia: None. R. Gorji: None. S. Najafi: None. H. Pahlavan: None. A. Sadeghian: None. S. Zabihyan: None. P. Sassannejad: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Baharvahdat, H., Qoorchi Moheb Seraj, F., Vaezi, M., Ebrahimnia, F., Gorji, R., Najafi, S., Pahlavan, H., Sadeghian, A., Zabihyan, S., Sassannejad, P. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-033 Optimization of endovascular treatment for patients with acute carotid plaque rupture and free- floating thrombus by use of two overlapping closed-cell stents with different radial force
ConclusionUse of the Carotid Wallstent as the first stent to secure the free-floating thrombus allows save delivery of the Xact stent which then adds a second closed-cell mesh layer as well as the needed radial force to expand the stent construct. This approach may decrease if not eliminate the need for post-stent angioplasty in the acute setting thus decreasing risk of thromboembolic complication.Disclosures A. Kuhn: None. J. Singh: None. S. Sarid: None. M. Garcia: None. A. Puri: 1; C; NIH, Microvention, Cerenovus, Medtronic Neurovascular and Stryker Neurovascular. 2; C; Medtronic Neurovascular, Stryker NeurovascularBalt,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Sarid, S., Garcia, M., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-073 Acute loading doses of antiplatelets and long-term antiplatelets regimen in stent-assisted repair of intracranial aneurysms
ConclusionsOur study revealed that LDAC in SARIA is associated with a low immediate and long-term TEE without added risk of ICH and good outcome with no mortality or permanent disability. Our antiplatelets regimen may be an option in SARIA. Further studies are required to evaluate our antiplatelets strategies on FD.Disclosures Y. Lodi: None. V. Reddy: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Lodi, Y., Reddy, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-106 Bilateral ACA H-configuration flow diversion for treatment of AComm aneurysms
ConclusionPlacement of bilateral ACA flow diverters for treatment of AComm aneurysms is a good endovascular option in selected patients. Reduction of flow across the AComm artery may suffice to reduce flow into the aneurysm sac and minimize the risk of aneurysm growth and/or rupture.Abstract E-106 Table 1 Patient Sex Age Aneurysm Rupture Status Largest diameter 1st flow diverter 2nd flow diverter Procedural complication DAPT 6-month follow-up 12-month follow-up 24- 36-month follow-up 1 F 59 Unruptured 3.2 mm 2.5x13 mm FRED X 2.5x13 mm FRED X none ASA 81 mg Plavix 75 mg Pending - - 2 F 54 Ruptured 0.8 mm 2...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Sarid, S., de Macedo Rodrigues, K., Garcia, M., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
How an Aggressive Treatment of No-reflow Phenomenon in Primary Percutaneous Coronary Intervention with High Thrombus Burden can Achieve a Grade III TIMI-flow: A Case Report
Conclusion Aggressive and precise treatment with a drug of choice is required to counteract the no-reflow phenomenon. Presently, only a limited range of first-line medications are available to treat this condition. Not only that, but several of the prescribed medications are not easily accessible, especially in developing countries. Therefore, we offer a novel combination medicaments consisting of nitroglycerin, heparin, and glycoprotein IIb/IIIa inhibitor as an alternative treatment of the no-reflow phenomenon. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme...
Source: International Journal of Angiology - April 10, 2023 Category: Cardiology Authors: Martha, Januar Wibawa Putra, Iwan Cahyo Santosa Kamarullah, William Husink, Aron Sihite, Teddy Arnold Tags: Case Report Source Type: research
Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure
CONCLUSION: Our findings showed that GPVI-fibrin interaction significantly contributes to the development of procoagulant platelets and that inhibition of GPVI signaling increases clot porosity. Clot contractibility was impaired by the integrin αIIbβ3 and Btk pathway inhibition. Thus, inhibition of GPVI-fibrin interactions can alleviate structural characteristics that contribute to a prothrombotic clot phenotype, having potential important implications for novel antithrombotic interventions.PMID:36696196 | DOI:10.1016/j.jtha.2022.09.004 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 25, 2023 Category: Hematology Authors: Julia S Gauer C édric Duval Rui-Gang Xu Fraser L Macrae Helen R McPherson Christian Tiede Darren Tomlinson Steve P Watson Robert A S Ari ëns Source Type: research
An Updated Review on Glycoprotein IIb/IIIa Inhibitors as Antiplatelet Agents: Basic and Clinical Perspectives
AbstractThe glycoprotein (GP) IIb/IIIa receptor is found integrin present in platelet aggregations. GP IIb/IIIa antagonists interfere with platelet cross-linking and platelet-derived thrombus formation through the competition with fibrinogen and von Willebrand factor. Currently, three parenteral GP IIb/IIIa competitors (tirofiban, eptifibatide, and abciximab) are approved for clinical use in patients affected by percutaneous coronary interventions (PCI) in the location of acute coronary syndrome (ACS). GP IIb/IIIa antagonists have their mechanism of action in platelet aggregation prevention, distal thromboembolism, and thr...
Source: High Blood Pressure and Cardiovascular Prevention - January 13, 2023 Category: Cardiology Source Type: research
Eptifibatide
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2023 Category: Drugs & Pharmacology Source Type: research
