Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
Eptifibatide-induced acute profound thrombocytopenia: A case report
Conclusion:
Eptifibatide, a glycoprotein IIa/IIIb inhibitor used in the management of acute coronary syndrome, can induce acute, profound thrombocytopenia that can have significant morbidity in patients. This case highlights this relatively rare side effect and the importance of monitoring blood counts and observing for any signs of bleeding or thrombosis that might occur in such patients. (Source: Medicine)
Source: Medicine - October 21, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Eptifibatide use in ischemic stroke patients undergoing endovascular thrombectomy: A matched cohort analysis
ConclusionIn this single-center analysis, EPT use during EVT was associated with a significantly higher rate of PH1/PH2 grade hemorrhages, but not with differences in sICH, 24-h NIHSS, or 90-day mortality. Randomized prospective trials are needed to determine the safety and efficacy of EPT in this population. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 27, 2022 Category: Neurology Source Type: research
[ASAP] Corrections to “An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer”
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00224 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - July 29, 2022 Category: Chemistry Authors: Annunziata D ’Ercole, Lorenzo Pacini, Giuseppina Sabatino, Matteo Zini, Lorenzo Milli, Francesca Nuti, Arianna Ribecai, Alfredo Paio, Paolo Rovero, and Anna Maria Papini Source Type: research
A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics
CONCLUSIONS: Our system is an adaptable platform for assessing the effects of multiple conditions and interventions on clot contraction kinetics in a regular laboratory setting, using readily available materials. The automated image processing software we developed will be made freely available for noncommercial uses. This assay system can be used to directly compare and define the effects of different treatments or genetic manipulations on platelet function and should provide a robust tool for future hemostasis/thrombosis research and therapeutic development.PMID:35873218 | PMC:PMC9301529 | DOI:10.1002/rth2.12755 (Source:...
Source: Thrombosis and Haemostasis - July 25, 2022 Category: Hematology Authors: Kanakanagavalli Shravani Prakhya Ya Luo John Adkins Xiaoyuan Hu Qing Jun Wang Sidney W Whiteheart Source Type: research
A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics
CONCLUSIONS: Our system is an adaptable platform for assessing the effects of multiple conditions and interventions on clot contraction kinetics in a regular laboratory setting, using readily available materials. The automated image processing software we developed will be made freely available for noncommercial uses. This assay system can be used to directly compare and define the effects of different treatments or genetic manipulations on platelet function and should provide a robust tool for future hemostasis/thrombosis research and therapeutic development.PMID:35873218 | PMC:PMC9301529 | DOI:10.1002/rth2.12755 (Source:...
Source: Thrombosis and Haemostasis - July 25, 2022 Category: Hematology Authors: Kanakanagavalli Shravani Prakhya Ya Luo John Adkins Xiaoyuan Hu Qing Jun Wang Sidney W Whiteheart Source Type: research
A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics
CONCLUSIONS: Our system is an adaptable platform for assessing the effects of multiple conditions and interventions on clot contraction kinetics in a regular laboratory setting, using readily available materials. The automated image processing software we developed will be made freely available for noncommercial uses. This assay system can be used to directly compare and define the effects of different treatments or genetic manipulations on platelet function and should provide a robust tool for future hemostasis/thrombosis research and therapeutic development.PMID:35873218 | PMC:PMC9301529 | DOI:10.1002/rth2.12755 (Source:...
Source: Thrombosis and Haemostasis - July 25, 2022 Category: Hematology Authors: Kanakanagavalli Shravani Prakhya Ya Luo John Adkins Xiaoyuan Hu Qing Jun Wang Sidney W Whiteheart Source Type: research
Unraveling the role of the homoarginine residue in antiplatelet drug eptifibatide in binding to the αIIbβ3 integrin receptor
Eptifibatide is an αIIbβ3 inhibitor that is currently used in the clinic. More than 10 scientific communications indicate that eptifibatide has a Lys-Gly-Asp or Arg-Gly-Asp sequence, while it actually has a hArg-Gly-Asp sequence. We aimed to unravel the importance of the homoarginine residue in eptifibatide in plate let activation and aggregation.Arg- and Lys-eptifibatide were synthesized by solid-phase peptide synthesis and measured in light transmission aggregometry, flow cytometry and whole blood thrombus formation under flow. (Source: Thrombosis Research)
Source: Thrombosis Research - July 25, 2022 Category: Hematology Authors: Danique L. van den Kerkhof, Magdolna Nagy, Kanin Wichapong, Sanne L.N. Brouns, Dennis P.L. Suylen, Tilman M. Hackeng, I. Dijkgraaf Tags: Full Length Article Source Type: research
E-157 Emergent intracranial stenting for symptomatic basilar artery and intradural vertebral artery stenosis
ConclusionEmergent intracranial stenting for symptomatic stenoses in the posterior circulation is feasible and safe when compared to the natural history of the disease.Disclosures A. Kuhn: None. J. Singh: None. F. Massari: None. A. Puri: 1; C; NIH, Microvention, Cerenovus, Medtronic Neurovascular and Stryker Neurovascular. 2; C; Medtronic Neurovascular, Stryker NeurovascularBalt, Q’Apel Medical, Cerenovus, Microvention, Imperative Care, Agile, Merit, CereVasc and Arsenal Medical. 4; C; InNeuroCo, Agile, Perfuze, Galaxy and NTI. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Massari, F., Puri, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
E-055 Internal carotid artery reconstruction with flow diverting stents in the treatment of acute ischemic stroke: technical considerations and medical management
ConclusionsFDS appear to be a safe and effective tool for reconstruction of a symptomatic dissection in tortuous cervical ICAs. Their flexibility allows conformation to complex anatomies and they can be traversed multiple times by aspiration catheters/stentrievers. We found excellent patency at follow up. The unique challenges posed by utilization of high-profile stents in acute stroke require appropriate technical execution and medical management.Disclosures E. Orru: None. F. Bounni: None. M. Marosfoi: None. N. Patel: None. A. Wakhloo: 1; C; Philips medical. 2; C; Stryker, Phenox. 4; C; InNeuroCo, EpiEP, Neural Analytics,...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Orru, E., Bounni, F., Marosfoi, M., Patel, N., Wakhloo, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
Validation of the GRACE Risk Score for Acute Coronary Syndrome Patients in an Asian Medical Centre
There are various risk scores to predict mortality risk among patients admitted for acute coronary syndrome (ACS), such as the Thrombolysis in MI (TIMI) score, Global Registry of Acute Coronary Events (GRACE) risk score and the Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin (eptifibatide) Therapy (PURSU... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 13, 2022 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
