Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway

Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the application of abciximab, eptifibatide, and tirofiban is restricted to patients undergoing percutaneous coronary intervention. On the other hand, the outside-in signaling of αⅡbβ3 in platelets appears to be responsible for thrombus stabilization, and selective interference with the propagation of outside-in signals might signify a new therapeutic strategy to preferentially inhibit platelet-rich arterial thrombosis with less bleeding issues caused by way of compromised major hemostasis. The purpose of this review is to describe the bidirectional signal transduction of integrin αIIbβ3 in platelets with a focus on outside-in signaling, more efficient and safer anti-αⅡbβ3 peptides, and the potential drug targets for future anti-platelet research.PMID:36380406 | DOI:10.2174/1389203724666221114113413
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Source Type: research