E-059 Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery
ConclusionsFor patients undergoing staged CAS-CTS, Eptifibatide bridging therapy is a viable temporary antiplatelet strategy with a favorable safety profile. This strategy enables a flexible range of time-intervals between procedures.Disclosures M. Caton: None. K. Narsinh: None. A. Baker: None. J. Rapp: None. W. Gasper: None. J. Iannuzzi: None. E. Tseng: None. M. Amans: None. S. Hetts: None. D. Cooke: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Caton, M., Narsinh, K., Baker, A., Rapp, J., Gasper, W., Iannuzzi, J., Tseng, E., Amans, M., Hetts, S., Cooke, D. Tags: Electronic poster abstracts Source Type: research
Mechanically-triggered Hybridization Chain Reaction
Angew Chem Int Ed Engl. 2021 Jul 9. doi: 10.1002/anie.202107660. Online ahead of print.ABSTRACTCells transmit piconewton forces to receptors to mediate processes such as migration and immune recognition. A major challenge in quantifying such forces is the sparsity of cell mechanical events. Accordingly, molecular tension is typically quantified with high resolution fluorescence microscopy, which hinders widespread adoption and application. Here, we report a mechanically-triggered hybridization chain reaction (mechano-HCR) that allows chemical amplification of mechanical events. The amplification is triggered when a cell re...
Source: Angewandte Chemie - July 9, 2021 Category: Chemistry Authors: Yuxin Duan Roxanne Glazier Alisina Bazrafshan Yuesong Hu Sk Aysha Rashid Brian Petrich Yonggang Ke Khalid Salaita Source Type: research
Mechanically-triggered Hybridization Chain Reaction
Angew Chem Int Ed Engl. 2021 Jul 9. doi: 10.1002/anie.202107660. Online ahead of print.ABSTRACTCells transmit piconewton forces to receptors to mediate processes such as migration and immune recognition. A major challenge in quantifying such forces is the sparsity of cell mechanical events. Accordingly, molecular tension is typically quantified with high resolution fluorescence microscopy, which hinders widespread adoption and application. Here, we report a mechanically-triggered hybridization chain reaction (mechano-HCR) that allows chemical amplification of mechanical events. The amplification is triggered when a cell re...
Source: Angewandte Chemie - July 9, 2021 Category: Chemistry Authors: Yuxin Duan Roxanne Glazier Alisina Bazrafshan Yuesong Hu Sk Aysha Rashid Brian Petrich Yonggang Ke Khalid Salaita Source Type: research
Low-Dose Eptifibatide for Tandem Occlusion in Stroke: Safety and Carotid Artery Patency [EXTRACRANIAL VASCULAR]
CONCLUSIONS:
Low-dose eptifibatide seemed to be safe in tandem occlusions (symptomatic intracranial hemorrhage, 2%), although asymptomatic cervical carotid artery re-occlusions still occurred in 14% of patients. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 12, 2021 Category: Radiology Authors: Jost, A., Roels, C., Brown, M., Janjua, R., Heck, D. Tags: EXTRACRANIAL VASCULAR Source Type: research
Complications and Management of Eptifibatide-Induced Thrombocytopenia
CONCLUSION AND RELEVANCE: Most cases of EIT were managed by withholding eptifibatide with platelet transfusion if necessary. The majority of complications included bleeding. However, significant procedure delays, prolonged hospital stay, thrombosis, and allergic reactions were also reported.PMID:33813877 | DOI:10.1177/10600280211006645 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Faisal Masood Saad Hashmi Adib Chaus Anna Hertsberg Eli D Ehrenpreis Source Type: research
Complications and Management of Eptifibatide-Induced Thrombocytopenia
CONCLUSION AND RELEVANCE: Most cases of EIT were managed by withholding eptifibatide with platelet transfusion if necessary. The majority of complications included bleeding. However, significant procedure delays, prolonged hospital stay, thrombosis, and allergic reactions were also reported.PMID:33813877 | DOI:10.1177/10600280211006645 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Faisal Masood Saad Hashmi Adib Chaus Anna Hertsberg Eli D Ehrenpreis Source Type: research
Complications and Management of Eptifibatide-Induced Thrombocytopenia
CONCLUSION AND RELEVANCE: Most cases of EIT were managed by withholding eptifibatide with platelet transfusion if necessary. The majority of complications included bleeding. However, significant procedure delays, prolonged hospital stay, thrombosis, and allergic reactions were also reported.PMID:33813877 | DOI:10.1177/10600280211006645 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Faisal Masood Saad Hashmi Adib Chaus Anna Hertsberg Eli D Ehrenpreis Source Type: research
Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation
CONCLUSIONS: Outside-in signaling activates the mainly NOX2-mediated ROS generation, which mediates Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.PMID:33691478 | DOI:10.1161/ATVBAHA.120.315773 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Zheng Xu Ying Liang M Keegan Delaney Yaping Zhang Kyungho Kim Jing Li Yanyan Bai Jaehyung Cho Masuko Ushio-Fukai Ni Cheng Xiaoping Du Source Type: research
Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation
CONCLUSIONS: Outside-in signaling activates the mainly NOX2-mediated ROS generation, which mediates Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.PMID:33691478 | DOI:10.1161/ATVBAHA.120.315773 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Zheng Xu Ying Liang M Keegan Delaney Yaping Zhang Kyungho Kim Jing Li Yanyan Bai Jaehyung Cho Masuko Ushio-Fukai Ni Cheng Xiaoping Du Source Type: research
Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation
CONCLUSIONS: Outside-in signaling activates the mainly NOX2-mediated ROS generation, which mediates Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.PMID:33691478 | DOI:10.1161/ATVBAHA.120.315773 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Zheng Xu Ying Liang M Keegan Delaney Yaping Zhang Kyungho Kim Jing Li Yanyan Bai Jaehyung Cho Masuko Ushio-Fukai Ni Cheng Xiaoping Du Source Type: research
Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation
CONCLUSIONS: Outside-in signaling activates the mainly NOX2-mediated ROS generation, which mediates Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.PMID:33691478 | DOI:10.1161/ATVBAHA.120.315773 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Zheng Xu Ying Liang M Keegan Delaney Yaping Zhang Kyungho Kim Jing Li Yanyan Bai Jaehyung Cho Masuko Ushio-Fukai Ni Cheng Xiaoping Du Source Type: research
Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation
CONCLUSIONS: Outside-in signaling activates the mainly NOX2-mediated ROS generation, which mediates Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.PMID:33691478 | DOI:10.1161/ATVBAHA.120.315773 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Zheng Xu Ying Liang M Keegan Delaney Yaping Zhang Kyungho Kim Jing Li Yanyan Bai Jaehyung Cho Masuko Ushio-Fukai Ni Cheng Xiaoping Du Source Type: research
Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation
CONCLUSIONS: Outside-in signaling activates the mainly NOX2-mediated ROS generation, which mediates Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.PMID:33691478 | DOI:10.1161/ATVBAHA.120.315773 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Zheng Xu Ying Liang M Keegan Delaney Yaping Zhang Kyungho Kim Jing Li Yanyan Bai Jaehyung Cho Masuko Ushio-Fukai Ni Cheng Xiaoping Du Source Type: research
Surface modification of polyurethane with eptifibatide-loaded degradable nanoparticles reducing risk of blood coagulation
Colloids Surf B Biointerfaces. 2021 Feb 13;201:111624. doi: 10.1016/j.colsurfb.2021.111624. Online ahead of print.ABSTRACTThe main purpose of the work was to develop a drug releasing coatings on the surface of medical devices exposed to blood flow, what should enable effective inhibition of blood coagulation process. As a part of the work, the process of encapsulating the anticoagulant drug eptifibatide (EPT) in poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles was developed. EPT encapsulation efficiency was 29.1 ± 2.1%, while the EPT loading percentage in the nanoparticles was 4.2 ± 0.3%. The PLGA nanoparticles were...
Source: Colloids and Surfaces - February 23, 2021 Category: Biotechnology Authors: Katarzyna Reczy ńska Roman Major Magdalena Kopernik El żbieta Pamuła Gabriela Imbir Hanna Plutecka Franz Bruckert Marcin Surmiak Source Type: research
Surface modification of polyurethane with eptifibatide-loaded degradable nanoparticles reducing risk of blood coagulation
Colloids Surf B Biointerfaces. 2021 Feb 13;201:111624. doi: 10.1016/j.colsurfb.2021.111624. Online ahead of print.ABSTRACTThe main purpose of the work was to develop a drug releasing coatings on the surface of medical devices exposed to blood flow, what should enable effective inhibition of blood coagulation process. As a part of the work, the process of encapsulating the anticoagulant drug eptifibatide (EPT) in poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles was developed. EPT encapsulation efficiency was 29.1 ± 2.1%, while the EPT loading percentage in the nanoparticles was 4.2 ± 0.3%. The PLGA nanoparticles were...
Source: Colloids and Surfaces - February 23, 2021 Category: Biotechnology Authors: Katarzyna Reczy ńska Roman Major Magdalena Kopernik El żbieta Pamuła Gabriela Imbir Hanna Plutecka Franz Bruckert Marcin Surmiak Source Type: research
