Intraoperative Eptifibatide Administration During Urgent Arterial Bypass in Neurosurgery
We describe 2 patients who underwent arterial bypass in whom eptifibatide was used successfully intraoperatively during neurosurgery for prevention of bypass occlusion. (Source: World Neurosurgery)
Source: World Neurosurgery - April 20, 2017 Category: Neurosurgery Authors: Vasilije Stambolija, Goran Mrak, Marin Lozic, Josip Ljevak, Martina Miklic Bublic, Miroslav Scap Tags: Case Report Source Type: research
Safety of Eptifibatide in Subarachnoid Hemorrhage Patients Requiring Antiplatelet Agents. (P2.285)
Conclusions:Our results indicate that administering IV Eptifibatide to prevent thrombotic complications after endovascular coil embolization in selected patients with aneurysmal subarachnoid hemorrhage is safe. Multicenter prospective trials are warranted to corroborate our findings.Disclosure: Dr. Mehta has nothing to disclose. Dr. Song has nothing to disclose. Dr. DeCarvalho has nothing to disclose. Dr. Z Arango has nothing to disclose. Dr. Kulhari has nothing to disclose. Dr. Kirmani has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mehta, S., Song, Y.-B., DeCarvalho, B., Arango, A. Z., Kulhari, A., Kirmani, J. F. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research
Role of heterotrimeric G proteins in platelet activation and clot formation in platelets treated with integrin αIIbβ3 inhibitor.
Authors: Budnik I, Shenkman B, Hauschner H, Zilinsky I, Savion N
Abstract
Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Gαq, Gαi, and Gα12/13 proteins. We have undertaken a study addressing the contribution of these G proteins to platelet activation and clot formation in the presence of eptifibatide, thus excluding outside-in signaling provided by integrin αIIbβ3-fibrinogen engagement. Selective and combined activation of the G proteins was achieved by using com...
Source: Platelets - April 14, 2017 Category: Hematology Tags: Platelets Source Type: research
Shear ‐sensitive nanocapsule drug release for site‐specific inhibition of occlusive thrombus formation
ConclusionsTargeted delivery of eptifibatide by shear‐sensitive nanocapsules offers site‐specific antiplatelet potential, and may form a basis for developing more potent and safer antiplatelet drugs. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - April 9, 2017 Category: Hematology Authors: C. P. Molloy, Y. Yao, H. Kammoun, T. Bonnard, T. Hoefer, K. Alt, F. Tovar ‐Lopez, G. Rosengarten, P. A. Ramsland, A. D. Meer, A. Berg, A. J. Murphy, C. E. Hagemeyer, K. Peter, E. Westein Tags: Original Article Source Type: research
Eptifibatide
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2017 Category: Drugs & Pharmacology Source Type: research
The comparative safety of abciximab versus eptifibatide in patients on dialysis undergoing percutaneous coronary intervention: Insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2)
ConclusionsDespite being contraindicated in dialysis, eptifibatide was used approximately 3.5 times more frequently than abciximab among dialysis patients undergoing PCI but was associated with similar in‐hospital outcomes. (Source: Journal of Interventional Cardiology)
Source: Journal of Interventional Cardiology - April 1, 2017 Category: Cardiology Authors: Devraj Sukul, Milan Seth, Theodore Schreiber, George Hanzel, Akshay Khandelwal, Louis A. Cannon, Thomas A. Lalonde, Hitinder S. Gurm Tags: ORIGINAL INVESTIGATION Source Type: research
Ischemic Stroke After Treatment of Intraprocedural Thrombosis During Stent-Assisted Coiling and Flow Diversion [Brief Report]
Conclusions—Current protocols for treatment of intraprocedural thrombosis associated with placement of intra-arterial devices were effective in preventing ischemic stroke in ≈80% of cases. Current smoking was the only independent predictor of ischemic stroke. (Source: Stroke)
Source: Stroke - March 27, 2017 Category: Neurology Authors: Nimer Adeeb, Christoph J. Griessenauer, Justin M. Moore, Paul M. Foreman, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Raghav Gupta, Carlos E. Baccin, Abdulrahman Alturki, Mark R. Harrigan, Adnan H. Siddiqui, Elad I. Levy, Christopher S. Ogilvy, Ajith J. Tags: Cerebral Aneurysm, Ischemic Stroke Brief Reports Source Type: research
Predictors of delayed and no-reflow as recognized with Thrombolysis in Myocardial Infarction [TIMI] flow grade following Primary Percutaneous Coronary Angioplasty.
Conclusion: A low TIMI flow is accompanied by a poorer survival and a higher MACE and is influenced by some clinical and vascular characteristics.
PMID: 28316667 [PubMed] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - March 23, 2017 Category: Journals (General) Tags: J Med Life Source Type: research
Shear sensitive nanocapsule drug release for site specific inhibition of occlusive thrombus formation.
CONCLUSIONS: Targeted delivery of eptifibatide by shear-sensitive nanocapsules offers site specific antiplatelet potential and may form a basis for developing more potent and safer antiplatelet drugs. This article is protected by copyright. All rights reserved.
PMID: 28267256 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 6, 2017 Category: Hematology Authors: Molloy CP, Yao Y, Kammoun H, Bonnard T, Hoefer T, Alt K, Tovar-Lopez F, Rosengarten G, Ramsland PA, van der Meer AD, van den Berg A, Murphy AJ, Hagemeyer CE, Peter K, Westein E Tags: J Thromb Haemost Source Type: research
Dual antiplatelet therapy and non-cardiac surgery: evolving issues and anesthetic implications.
Authors: Song JW, Soh S, Shim JK
Abstract
Dual antiplatelet therapy (DAPT) consisting of aspirin plus a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) is imperative for the treatment of acute coronary syndrome, particularly during the re-endothelialization period after percutaneous coronary intervention (PCI). When patients undergo surgery during this period, the consequences of stent thrombosis are far more serious than those of bleeding complications, except in cases of intracranial surgery. The recommendations for perioperative DAPT have changed with emerging evidence regarding the improved eff...
Source: Korean Journal of Anesthesiology - February 13, 2017 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
Encapsulation of eptifibatide in RGD-modified nanoliposomes improves platelet aggregation inhibitory activity
In conclusion, the present nanoliposome formulation can be regarded as a new delivery system for protection and enhancement of the antiplatelet activity of eptifibatide. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - January 31, 2017 Category: Hematology Source Type: research
Abstract B62: Role of the blood microenvironment in the upregulation of oncoproteins in circulating pancreatic cancer cells
Conclusion: We show that the expression of c-MYC in PANC-1 cancer cells can be upregulated by platelets, revealing a novel mechanism of platelet action in the progression of cancer and suggesting that the overexpression of c-MYC at the metastatic niche may be inhibited through the use of platelet inhibitors. We are currently characterizing the molecular underpinnings of platelet-mediated c-MYC regulation with respect to the contribution of platelets to cancer cell proliferation and growth.Citation Format: Annachiara Mitrugno, Katherine Pelz, Rosalie Sears, Owen McCarty. Role of the blood microenvironment in the upregulatio...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Annachiara Mitrugno, Katherine Pelz, Rosalie Sears, Owen McCarty Tags: Other Topics Source Type: research
Fasting Glucose, NT-proBNP, Treatment with Eptifibatide, and Outcomes in Non –ST-Segment Elevation Acute Coronary Syndromes: An Analysis from EARLY ACS
Higher N-terminal pro –B-type natriuretic peptide (NT-proBNP) levels have been linked to a more favorable glucometabolic profile. Little is known about the interaction of NT-proBNP and fasting glucose in non–ST-segment elevation acute coronary syndrome (NSTE ACS). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 3, 2017 Category: Cardiology Authors: Serdar Farhan, Robert M. Clare, Rudolf Jarai, Robert P. Giugliano, Yuliya Lokhnygina, Robert A. Harrington, L. Kristin Newby, Kurt Huber Source Type: research
Intracoronary Eptifibatide During Primary Percutaneous Coronary Intervention in Early Versus Late Presenters with ST Segment Elevation Myocardial Infarction: A Randomized Trial
ConclusionIC eptifibatide might improve the reperfusion markers during PPCI for STEMI patients presenting after 3 h from onset of symptoms. A large randomized study is recommended to ascertain the benefits of IC eptifibatide in late presenters on clinical outcomes. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 13, 2016 Category: Cardiology Source Type: research
Intracoronary versus Intravenous eptifibatide during percutaneous coronary intervention for acute ST-segment elevation myocardial infarction; a randomized controlled trial
AbstractAlthough aspirin and clopidogrel seem to be quite enough during low risk percutaneous coronary intervention (PCI), the combination may need some reinforcement in complex situations such as primary PCI. By modifying the route and also the duration of administration, glycoprotein IIb/IIIa inhibitors might be a viable option. The aim of this study is to compare the benefits and disadvantages of three different methods of administration of eptifibatide in primary PCI population. Primary PCI candidates were randomized in three groups on which three different methods of administration of eptifibitide were tested: intrave...
Source: Cardiovascular Intervention and Therapeutics - August 16, 2016 Category: Cardiology Source Type: research
