Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility
CONCLUSIONS: For patients undergoing staged CAS-CTS, Eptifibatide bridging therapy is a viable temporary antiplatelet strategy with a favorable safety profile. This strategy enables a flexible range of time-intervals between procedures.PMID:35341420 | DOI:10.1177/17085381221084813 (Source: Vascular)
Source: Vascular - March 28, 2022 Category: Surgery Authors: M Travis Caton Kazim H Narsinh Amanda Baker Matthew R Amans Steven W Hetts Joseph H Rapp James C Ianuzzi Elaine Tseng Warren J Gasper Daniel L Cooke Source Type: research
Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility
CONCLUSIONS: For patients undergoing staged CAS-CTS, Eptifibatide bridging therapy is a viable temporary antiplatelet strategy with a favorable safety profile. This strategy enables a flexible range of time-intervals between procedures.PMID:35341420 | DOI:10.1177/17085381221084813 (Source: Vascular)
Source: Vascular - March 28, 2022 Category: Surgery Authors: M Travis Caton Kazim H Narsinh Amanda Baker Matthew R Amans Steven W Hetts Joseph H Rapp James C Ianuzzi Elaine Tseng Warren J Gasper Daniel L Cooke Source Type: research
Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility
CONCLUSIONS: For patients undergoing staged CAS-CTS, Eptifibatide bridging therapy is a viable temporary antiplatelet strategy with a favorable safety profile. This strategy enables a flexible range of time-intervals between procedures.PMID:35341420 | DOI:10.1177/17085381221084813 (Source: Vascular)
Source: Vascular - March 28, 2022 Category: Surgery Authors: M Travis Caton Kazim H Narsinh Amanda Baker Matthew R Amans Steven W Hetts Joseph H Rapp James C Ianuzzi Elaine Tseng Warren J Gasper Daniel L Cooke Source Type: research
Safety and Efficacy of Cangrelor Among Three Antiplatelet Regimens During Stent-Assisted Endovascular Treatment of Unruptured Intracranial Aneurysm: A Single-Center Retrospective Study
ConclusionThis single-center retrospective study compared 3 antiplatelet regimens, finding no significant difference in the safety and efficacy in the context of endovascular treatments of unruptured aneurysm using stent or flow diverters. This study adds data for the Cangrelor use and suggests its usefulness in the field of neuro-endovascular intervention. Randomized controlled studies are warranted to confirm these results. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 4, 2022 Category: Neurology Source Type: research
Safety and Efficacy of Periprocedural Bridging With Cangrelor Versus Eptifibatide
This study aims to assess the safety and efficacy of cangrelor compared with eptifibatide when used in a periprocedural setting. The primary outcome of this retrospective cohort study was the incidence of bleeding events defined by the global use of strategies to open occluded coronary arteries criteria, and the secondary outcomes include the transfusion requirements, inpatient major cardiac adverse events, and cost savings per patient. A total of 75 patients were included who were bridged to procedures (cangrelor, n = 50; eptifibatide, n = 25). There were no significant differences in overall bleeding events defined by gl...
Source: Journal of Cardiovascular Pharmacology - March 1, 2022 Category: Cardiology Tags: Original Article Source Type: research
[ASAP] An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.1c00368 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - November 24, 2021 Category: Chemistry Authors: Annunziata D ’Ercole, Lorenzo Pacini, Giuseppina Sabatino, Matteo Zini, Francesca Nuti, Arianna Ribecai, Alfredo Paio, Paolo Rovero, and Anna Maria Papini Source Type: research
Efficacy outcomes and safety measures of intravenous tirofiban or eptifibatide for patients with acute ischemic stroke: a systematic review and meta-analysis of prospective studies
AbstractTo review the literature for randomized control trials (RCTs) and prospective cohort studies investigating the safety and efficacy of tirofiban and eptifibatide in patients with acute ischemic stroke (AIS). PubMed, Embase, and the Cochrane library were searched for available papers published up to September 2021. The efficacy was evaluated based on the 3-month favorable outcome [modified Rankin scale (mRS) = 0–1], functional outcome (mRS = 0–2), and the last available National Institutes of Health Stroke Scale (NIHSS) score measured in each study. Twelve studies (two RCTs and 10 prospective cohorts) an...
Source: Journal of Thrombosis and Thrombolysis - November 15, 2021 Category: Hematology Source Type: research
Safety and Efficacy of Pharmaco-invasive Approach Using Streptokinase Compared With Primary Percutaneous Coronary Angiography
Conclusion:
Utilizing streptokinase in early re-perfused patients by PI approach (≤3 hrs) seems safe and efficient when PPCI delay (>120 min from symptom onset) is the other option. (Source: Critical Pathways in Cardiology)
Source: Critical Pathways in Cardiology - August 28, 2021 Category: Cardiology Tags: Original Study Source Type: research
EP01* Safety and efficacy of eptifibatide for endovascular intracranial aneurysm treatment
ConclusionsBased on our experience, we propose an algorithm for eptifibatide administration for endovascular aneurysm treatment based on patient characteristics as well as the postinterventional angiogram.ReferencesPierot L, et al. Intraoperative complications of endovascular treatment of intracranial aneurysms with coiling or balloon-assisted coiling in a prospective multicenter cohort of 1088 participants: analysis of recanalization after endovascular treatment of intracranial aneurysm (ARETA) study. Radiology 2020. PMID: 32096707.Dornbos D, Katz JS, Youssef P, Powers CJ, Nimjee SM. Glycoprotein IIb/IIIa inhibitors in pr...
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Schubert, T., Husain, H., Thurner, P., Madjidyar, J., Jan, W., Kulcsar, Z. Tags: Haemorrhagic Source Type: research
Efficacy of intravenous eptifibatide in primary percutaneous coronary intervention patients
J Med Life. 2021 May-Jun;14(3):376-382. doi: 10.25122/jml-2021-0035.ABSTRACTEarly and complete restoration of blood flow in closed coronary arteries is the main goal in treating patients with myocardial infarction. Primary angioplasty is not always successful in establishing myocardial blood flow. Although the strategy of adding eptifibatide leads to better blood flow, its value as part of a routine strategy is questionable. Therefore, this study was performed to evaluate the efficacy of intravenous eptifibatide in primary percutaneous coronary intervention (PCI) patients. This clinical, randomized, double-blind trial was ...
Source: Journal of Medicine and Life - August 11, 2021 Category: General Medicine Authors: Rozita Jalalian Samad Golshani Hossein Farsavian Mahsa Vatani Ali Asghar Farsavian Source Type: research
