Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure

CONCLUSION: Our findings showed that GPVI-fibrin interaction significantly contributes to the development of procoagulant platelets and that inhibition of GPVI signaling increases clot porosity. Clot contractibility was impaired by the integrin αIIbβ3 and Btk pathway inhibition. Thus, inhibition of GPVI-fibrin interactions can alleviate structural characteristics that contribute to a prothrombotic clot phenotype, having potential important implications for novel antithrombotic interventions.PMID:36696196 | DOI:10.1016/j.jtha.2022.09.004

Source: Thrombosis and Haemostasis - January 25, 2023 Category: Hematology Authors: Julia S Gauer C édric Duval Rui-Gang Xu Fraser L Macrae Helen R McPherson Christian Tiede Darren Tomlinson Steve P Watson Robert A S Ari ëns Source Type: research