Development of a simple paste for 3D printing of drug formulations containing a mesoporous material loaded with a poorly water-soluble drug
This study showcases the feasibility of a straightforward yet groundbreaking hybrid 3D printing system employing SSE to incorporate drug-loaded mesoporous magnesium carbonate (MMC) into two different drug formulations, each designed for distinct administration routes. MMC was loaded with the poorly water-soluble drug ibuprofen via a solvent evaporation method and mixed with PEG 400 as a binder and lubricant, facilitating subsequent SSE. The formulation is non-aqueous, unlike most pastes which are used for SSE, and thus is beneficial for the incorporation of poorly water-soluble drugs. The 3D printing process yielded tablet...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 27, 2024 Category: Drugs & Pharmacology Authors: Christos S Katsiotis Evgenii Tikhomirov Christos Leliopoulos Maria Str ømme Ken Welch Source Type: research
Development of a simple paste for 3D printing of drug formulations containing a mesoporous material loaded with a poorly water-soluble drug
This study showcases the feasibility of a straightforward yet groundbreaking hybrid 3D printing system employing SSE to incorporate drug-loaded mesoporous magnesium carbonate (MMC) into two different drug formulations, each designed for distinct administration routes. MMC was loaded with the poorly water-soluble drug ibuprofen via a solvent evaporation method and mixed with PEG 400 as a binder and lubricant, facilitating subsequent SSE. The formulation is non-aqueous, unlike most pastes which are used for SSE, and thus is beneficial for the incorporation of poorly water-soluble drugs. The 3D printing process yielded tablet...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 27, 2024 Category: Drugs & Pharmacology Authors: Christos S Katsiotis Evgenii Tikhomirov Christos Leliopoulos Maria Str ømme Ken Welch Source Type: research
Retraction Note: Photodegradation of ibuprofen laden-wastewater using sea-mud catalyst/H2O2 system: evaluation of sonication modes and energy consumption
Environ Sci Pollut Res Int. 2024 Mar 26. doi: 10.1007/s11356-024-33075-6. Online ahead of print.NO ABSTRACTPMID:38528226 | DOI:10.1007/s11356-024-33075-6 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 26, 2024 Category: Environmental Health Authors: Zahra Asadi Sina Dobaradaran Hossein Arfaeinia Mohsen Omidvar Sima Farjadfard Rauf Foroutan Bahman Ramavandi Rafael Luque Source Type: research
Retraction Note: Photodegradation of ibuprofen laden-wastewater using sea-mud catalyst/H2O2 system: evaluation of sonication modes and energy consumption
Environ Sci Pollut Res Int. 2024 Mar 26. doi: 10.1007/s11356-024-33075-6. Online ahead of print.NO ABSTRACTPMID:38528226 | DOI:10.1007/s11356-024-33075-6 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 26, 2024 Category: Environmental Health Authors: Zahra Asadi Sina Dobaradaran Hossein Arfaeinia Mohsen Omidvar Sima Farjadfard Rauf Foroutan Bahman Ramavandi Rafael Luque Source Type: research
Ultrasonic-assisted synthesis of CaCu < sub > 3 < /sub > Ti < sub > 4 < /sub > O < sub > 12 < /sub > /reduced graphene oxide composites for enhanced photocatalytic degradation of pharmaceutical products: Ibuprofen and Ciprofloxacin
The objective of this research is to create a highly effective approach for eliminating pollutants from the environment through the process of photocatalytic degradation. The study centers around the production of composites consisting of CaCu3Ti4O12 (CCTO) and reduced graphene oxide (rGO) using an ultrasonic-assisted method, with a focus on their capacity to degrade ibuprofen (IBF) and ciprofloxacin (CIP) via photodegradation. The impact of rGO on the structure, morphology, and optical properties of CCTO was inspected using XRD, FTIR, Raman, FESEM, XPS, BET, and UV-Vis. Morphology characterization showed that rGO particle...
Source: Environmental Science and Pollution Research International - March 22, 2024 Category: Environmental Health Authors: Mohsen Ahmadipour Mohammad Rezaei Ardani Mohsen Sarafbidabad Nadhem Missaoui Meenaloshini Satgunam Ramesh Singh Hamza Kahri Ujjwal Pal Ai Ling Pang Muhammad Saqlain Iqbal Renuka Garg Anish Bhattacharya Source Type: research
Ultrasonic-assisted synthesis of CaCu < sub > 3 < /sub > Ti < sub > 4 < /sub > O < sub > 12 < /sub > /reduced graphene oxide composites for enhanced photocatalytic degradation of pharmaceutical products: Ibuprofen and Ciprofloxacin
The objective of this research is to create a highly effective approach for eliminating pollutants from the environment through the process of photocatalytic degradation. The study centers around the production of composites consisting of CaCu3Ti4O12 (CCTO) and reduced graphene oxide (rGO) using an ultrasonic-assisted method, with a focus on their capacity to degrade ibuprofen (IBF) and ciprofloxacin (CIP) via photodegradation. The impact of rGO on the structure, morphology, and optical properties of CCTO was inspected using XRD, FTIR, Raman, FESEM, XPS, BET, and UV-Vis. Morphology characterization showed that rGO particle...
Source: Environmental Science and Pollution Research International - March 22, 2024 Category: Environmental Health Authors: Mohsen Ahmadipour Mohammad Rezaei Ardani Mohsen Sarafbidabad Nadhem Missaoui Meenaloshini Satgunam Ramesh Singh Hamza Kahri Ujjwal Pal Ai Ling Pang Muhammad Saqlain Iqbal Renuka Garg Anish Bhattacharya Source Type: research
Clinical validation of a fast-acting acetaminophen: a randomized, active and placebo controlled dental pain study
Conclusions: This study supports previous studies, demonstrating faster onset of analgesia with FA-acetaminophen 1000 mg compared to OTC ES-acetaminophen 1000 mg and OTC LG-ibuprofen 400 mg.ClinicalTrials.gov Identifier: NCT03224403 https://clinicaltrials.gov/ct2/show/NCT03224403.PMID:38505928 | DOI:10.1080/03007995.2024.2331159 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2024 Category: Research Authors: Andrew Myers Todd Bertoch Paul Zhang Stephen A Cooper Source Type: research
Polyethyleneimine-functionalized magnetic sugarcane bagasse cellulose film for the efficient adsorption of ibuprofen
In conclusion, P-SBC/Fe3O4 film is an environmentally friendly and cost-effective adsorbent with significant potential for effectively removing IBP, while maintaining its efficacy over multiple cycles.PMID:38508562 | DOI:10.1016/j.ijbiomac.2024.130969 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 20, 2024 Category: Biochemistry Authors: Yang Liu Yan-Shu Xiong Ming-Xing Li Wen Li Kai Li Source Type: research
Clinical validation of a fast-acting acetaminophen: a randomized, active and placebo controlled dental pain study
Conclusions: This study supports previous studies, demonstrating faster onset of analgesia with FA-acetaminophen 1000 mg compared to OTC ES-acetaminophen 1000 mg and OTC LG-ibuprofen 400 mg.ClinicalTrials.gov Identifier: NCT03224403 https://clinicaltrials.gov/ct2/show/NCT03224403.PMID:38505928 | DOI:10.1080/03007995.2024.2331159 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2024 Category: Research Authors: Andrew Myers Todd Bertoch Paul Zhang Stephen A Cooper Source Type: research
Polyethyleneimine-functionalized magnetic sugarcane bagasse cellulose film for the efficient adsorption of ibuprofen
In conclusion, P-SBC/Fe3O4 film is an environmentally friendly and cost-effective adsorbent with significant potential for effectively removing IBP, while maintaining its efficacy over multiple cycles.PMID:38508562 | DOI:10.1016/j.ijbiomac.2024.130969 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 20, 2024 Category: Biochemistry Authors: Yang Liu Yan-Shu Xiong Ming-Xing Li Wen Li Kai Li Source Type: research
The effect of lacosamide on calcitonin gene-related peptide serum level in episodic migraine patients: a randomized, controlled trial
ConclusionThe daily use of lacosamide 50 mg Bid for three months in episodic migraine patients was associated with a significant reduction in serum CGRP-LI, better clinical outcomes regarding frequency and duration of migraine attacks, and was well tolerated by patients. These results were derived from an open-label pilot study that need ed to be thoroughly investigated by a large-scale, randomized, double-blinded, placebo-controlled study.Trial registration: We registered our trial on ClinicalTrials.gov, named after"The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients," and with a c...
Source: Acta Neurologica Belgica - March 19, 2024 Category: Neurology Source Type: research
The effect of oral analgesic premedication on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis: A randomized clinical trial
Conclusions: Premedication with Pharmapain (an anti-inflammatory agent) and dexamethasone (a corticosteroid) does not enhance the success rate of the IANB technique in mandibular molars with irreversible pulpitis compared to placebo. However, the use of dexamethasone was significantly more effective than Pharmapain in reducing pain severity at inserting the first endodontic file. (Source: Journal of Dental Materials and Techniques)
Source: Journal of Dental Materials and Techniques - March 17, 2024 Category: Dentistry Source Type: research
Ototoxic and nephrotoxic drugs in neonatal intensive care units: results of a Spanish and Italian survey
Conclusions:The study underscores the need for clinical guidelines and uniform practices in managing ototoxic and nephrotoxic drugs in neonatal units. Awareness is high, but inconsistencies in practices indicate a necessity for standardization, including the implementation of therapeutic drug monitoring and the involvement of clinical pharmacologists. Addressing these issues is crucial for optimizing neonatal care in Southern Europe.What is Known:• Neonates in intensive care face a high risk of nephrotoxicity and ototoxicity from drugs like aminoglycosides, vancomycin, loop diuretics, and ibuprofen.• Therapeutic drug m...
Source: European Journal of Pediatrics - March 16, 2024 Category: Pediatrics Source Type: research
Quantum chemistry and pharmacy: diagnostic check of the thermochemistry of ibuprofen
Chemphyschem. 2024 Mar 12:e202400066. doi: 10.1002/cphc.202400066. Online ahead of print.ABSTRACTThe thermodynamic data on ibuprofen available in the literature shows that the disarray of experimental results is unacceptable for this very important drug. The data on ibuprofens available in the literature were collected, combined with our complementary experimental results and evaluated. The enthalpies of combustion and formation of the crystalline RS-(±)- and S-(+)-ibuprofens were measured using high-precision combustion calorimetry. The temperature dependence of the vapour pressure of S-(+)-ibuprofen was measured using t...
Source: Chemphyschem - March 12, 2024 Category: Chemistry Authors: Vladimir N Emel Yanenko Kseniya V Zherikova Sergey P Verevkin Source Type: research
Quantum chemistry and pharmacy: diagnostic check of the thermochemistry of ibuprofen
Chemphyschem. 2024 Mar 12:e202400066. doi: 10.1002/cphc.202400066. Online ahead of print.ABSTRACTThe thermodynamic data on ibuprofen available in the literature shows that the disarray of experimental results is unacceptable for this very important drug. The data on ibuprofens available in the literature were collected, combined with our complementary experimental results and evaluated. The enthalpies of combustion and formation of the crystalline RS-(±)- and S-(+)-ibuprofens were measured using high-precision combustion calorimetry. The temperature dependence of the vapour pressure of S-(+)-ibuprofen was measured using t...
Source: Chemphyschem - March 12, 2024 Category: Chemistry Authors: Vladimir N Emel Yanenko Kseniya V Zherikova Sergey P Verevkin Source Type: research
