Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
CONCLUSION: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.PMID:38579298 | DOI:10.57187/s.3535 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Stephan Gut Marlene Rauch Manuel Haschke Carola A Huber Jan Gaertner Nadine Schur Christoph R Meier Julia Spoendlin Source Type: research
Use of unlicensed drugs in a Swiss Pediatric University Hospital and associated prescribing error rates - a retrospective observational study
CONCLUSIONS: Unlicensed drugs are frequently prescribed in this paediatric hospital setting in Switzerland. Around every tenth prescription is an unlicensed drug. Because unlicensed drugs showed a significantly higher rate of prescribing errors, licensed drugs are favourable in terms of medication safety and should be prescribed whenever possible. If no licensed drug is available, imported drugs should be favoured over formula drugs due to lower prescribing error rates. To increase medication safety in paediatrics in Switzerland, efforts are necessary to increase the number of suitable licensed drug formulations for paedia...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Aylin Satir Miriam Pfiffner Christoph R Meier Angela Caduff Good Source Type: research
Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
CONCLUSION: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.PMID:38579298 | DOI:10.57187/s.3535 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Stephan Gut Marlene Rauch Manuel Haschke Carola A Huber Jan Gaertner Nadine Schur Christoph R Meier Julia Spoendlin Source Type: research
Use of unlicensed drugs in a Swiss Pediatric University Hospital and associated prescribing error rates - a retrospective observational study
CONCLUSIONS: Unlicensed drugs are frequently prescribed in this paediatric hospital setting in Switzerland. Around every tenth prescription is an unlicensed drug. Because unlicensed drugs showed a significantly higher rate of prescribing errors, licensed drugs are favourable in terms of medication safety and should be prescribed whenever possible. If no licensed drug is available, imported drugs should be favoured over formula drugs due to lower prescribing error rates. To increase medication safety in paediatrics in Switzerland, efforts are necessary to increase the number of suitable licensed drug formulations for paedia...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Aylin Satir Miriam Pfiffner Christoph R Meier Angela Caduff Good Source Type: research
Molecules, Vol. 29, Pages 1641: Kaempferol 3-O-rutinoside, a Flavone Derived from Tetrastigma hemsleyanum Diels et Gilg, Reduces Body Temperature through Accelerating the Elimination of IL-6 and TNF- & alpha; in a Mouse Fever Model
This study aimed to isolate and identify the chemicals with antipyretic bioactivity in T. hemsleyanum extracts and to provide an explanation for the use of T. hemsleyanum as a Chinese herbal medicine for fever treatment. Our results demonstrate that kaempferol 3-rutinoside (K3OR) could be successfully isolated and purified from the roots of T. hemsleyanum. Furthermore, K3OR exhibited a significant reduction in rectal temperature in a mouse model of fever. Notably, a 4 μM concentration of K3OR showed more effective antipyretic effects than ibuprofen and acetaminophen. To explore the underlying mechanism, we condu...
Source: Molecules - April 5, 2024 Category: Chemistry Authors: Weilong Zheng Haina Wang Xue Wang Xin Li Jiahuan Hu Xiangyu Zi Yufeng Zhou Duotao Pan Yongqian Fu Tags: Article Source Type: research
Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R
CONCLUSION: Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R axis.PMID:38572785 | DOI:10.1111/cns.14657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Waimei Si Zhenni Chen Jing Bei Shiquan Chang Yachun Zheng Li Gao Guoping Zhao Xin Li Di Zhang Source Type: research
Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin
Biomacromolecules. 2024 Apr 4. doi: 10.1021/acs.biomac.4c00010. Online ahead of print.ABSTRACTAlbumin nanoparticles are widely used in biomedicine due to their safety, low immunogenicity, and prolonged circulation. However, incorporating therapeutic molecules into these carriers faces challenges due to limited binding sites, restricting drug conjugation efficiency. We introduce a universal nanocarrier platform (X-UNP) using polyphenol-based engineering to incorporate phenolic moieties into albumin nanoparticles. Integration of catechol or galloyl groups significantly enhances drug binding and broadens the drug conjugation ...
Source: Biomacromolecules - April 4, 2024 Category: Biochemistry Authors: Haojie Zhang Yunxiang He Yajing Zhang Jiezhou Pan Tingxu Guo Huijun Huang Mengyuan Dai Jiaojiao Shang Guidong Gong Junling Guo Source Type: research
Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin
Biomacromolecules. 2024 Apr 4. doi: 10.1021/acs.biomac.4c00010. Online ahead of print.ABSTRACTAlbumin nanoparticles are widely used in biomedicine due to their safety, low immunogenicity, and prolonged circulation. However, incorporating therapeutic molecules into these carriers faces challenges due to limited binding sites, restricting drug conjugation efficiency. We introduce a universal nanocarrier platform (X-UNP) using polyphenol-based engineering to incorporate phenolic moieties into albumin nanoparticles. Integration of catechol or galloyl groups significantly enhances drug binding and broadens the drug conjugation ...
Source: Biomacromolecules - April 4, 2024 Category: Biochemistry Authors: Haojie Zhang Yunxiang He Yajing Zhang Jiezhou Pan Tingxu Guo Huijun Huang Mengyuan Dai Jiaojiao Shang Guidong Gong Junling Guo Source Type: research
Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R
CONCLUSION: Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R axis.PMID:38572785 | PMC:PMC10993342 | DOI:10.1111/cns.14657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Waimei Si Zhenni Chen Jing Bei Shiquan Chang Yachun Zheng Li Gao Guoping Zhao Xin Li Di Zhang Source Type: research
Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin
Biomacromolecules. 2024 Apr 4. doi: 10.1021/acs.biomac.4c00010. Online ahead of print.ABSTRACTAlbumin nanoparticles are widely used in biomedicine due to their safety, low immunogenicity, and prolonged circulation. However, incorporating therapeutic molecules into these carriers faces challenges due to limited binding sites, restricting drug conjugation efficiency. We introduce a universal nanocarrier platform (X-UNP) using polyphenol-based engineering to incorporate phenolic moieties into albumin nanoparticles. Integration of catechol or galloyl groups significantly enhances drug binding and broadens the drug conjugation ...
Source: Biomacromolecules - April 4, 2024 Category: Biochemistry Authors: Haojie Zhang Yunxiang He Yajing Zhang Jiezhou Pan Tingxu Guo Huijun Huang Mengyuan Dai Jiaojiao Shang Guidong Gong Junling Guo Source Type: research
Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R
CONCLUSION: Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R axis.PMID:38572785 | PMC:PMC10993342 | DOI:10.1111/cns.14657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Waimei Si Zhenni Chen Jing Bei Shiquan Chang Yachun Zheng Li Gao Guoping Zhao Xin Li Di Zhang Source Type: research
Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin
Biomacromolecules. 2024 Apr 4. doi: 10.1021/acs.biomac.4c00010. Online ahead of print.ABSTRACTAlbumin nanoparticles are widely used in biomedicine due to their safety, low immunogenicity, and prolonged circulation. However, incorporating therapeutic molecules into these carriers faces challenges due to limited binding sites, restricting drug conjugation efficiency. We introduce a universal nanocarrier platform (X-UNP) using polyphenol-based engineering to incorporate phenolic moieties into albumin nanoparticles. Integration of catechol or galloyl groups significantly enhances drug binding and broadens the drug conjugation ...
Source: Biomacromolecules - April 4, 2024 Category: Biochemistry Authors: Haojie Zhang Yunxiang He Yajing Zhang Jiezhou Pan Tingxu Guo Huijun Huang Mengyuan Dai Jiaojiao Shang Guidong Gong Junling Guo Source Type: research
Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R
CONCLUSION: Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R axis.PMID:38572785 | PMC:PMC10993342 | DOI:10.1111/cns.14657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Waimei Si Zhenni Chen Jing Bei Shiquan Chang Yachun Zheng Li Gao Guoping Zhao Xin Li Di Zhang Source Type: research
Mechanistic Modeling of In Vitro Biopharmaceutic Data for a Weak Acid Drug: A Pathway Towards Deriving Fundamental Parameters for Physiologically Based Biopharmaceutic Modeling
The objective of this tutorial is to (1) review processes and parameters contributing to oral drug absorption in increasing levels of complexity, (2) outline a general physiologically based biopharmaceutic modeling workflow for weak acids, and (3) illustrate the outlined concepts via an ibuprofen (i.e., a weak, poorly soluble acid) case example in order to provide practical guidance on how to integrate biopharmaceutic and physiological data to better understand oral drug absorption. In the future, we plan to explore the usefulness of this tutorial/roadmap to inform the development of PBPK models for BCS 2 weak bases, by ex...
Source: The AAPS Journal - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Efficacy evaluation of Mongolian medical warm acupuncture for sciatica caused by lumbar disc herniation: a randomized, controlled, single-blind clinical trial
CONCLUSIONS: Mongolian medical warm acupuncture effectively relieves leg and waist pain and improves the total therapeutic effect and the quality of daily life for patients with sciatica caused by LDH, with significant long-term efficacy. Our study provides a basis for warm acupuncture in the treatment of sciatica caused by LDH. Chinese Clinical Trial Registry ID: ChiCTR- INR-15007413.PMID:38567586 | DOI:10.26355/eurrev_202403_35727 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: L-G Si R-N A R Mu Q-Z Wu L-T Ga L Bai R-G-T A L-D Bao G-L A Source Type: research
