Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin

Biomacromolecules. 2024 Apr 4. doi: 10.1021/acs.biomac.4c00010. Online ahead of print.ABSTRACTAlbumin nanoparticles are widely used in biomedicine due to their safety, low immunogenicity, and prolonged circulation. However, incorporating therapeutic molecules into these carriers faces challenges due to limited binding sites, restricting drug conjugation efficiency. We introduce a universal nanocarrier platform (X-UNP) using polyphenol-based engineering to incorporate phenolic moieties into albumin nanoparticles. Integration of catechol or galloyl groups significantly enhances drug binding and broadens the drug conjugation possibilities. Our study presents a library of X-UNP nanoparticles with improved drug-loading efficiency, achieving up to 96% across 10 clinically used drugs, surpassing conventional methods. Notably, ibuprofen-UNP nanoparticles exhibit a 5-fold increase in half-life compared with free ibuprofen, enhancing in vivo analgesic and anti-inflammatory effectiveness. This research establishes a versatile platform for protein-based nanosized materials accommodating various therapeutic agents in biotechnological applications.PMID:38574372 | DOI:10.1021/acs.biomac.4c00010

Source: Biomacromolecules - April 4, 2024 Category: Biochemistry Authors: Haojie Zhang Yunxiang He Yajing Zhang Jiezhou Pan Tingxu Guo Huijun Huang Mengyuan Dai Jiaojiao Shang Guidong Gong Junling Guo Source Type: research