Hyaluronic acid-ibuprofen conjugation: a novel ototherapeutic approach protecting inner ear cells from inflammation-mediated damage
There is a substantial need of effective drugs for the treatment of hearing loss, which affects nearly 500 million individuals globally. Hearing loss can be the result of intense or prolonged noise exposure, ototoxic drugs, infections, and trauma, which trigger inflammatory signaling cascades that lead to irreversible damage to cochlear structures. To address this, we developed and characterized a series of covalent conjugates of anti-inflammatory drugs to hyaluronic acid (HA), for potential use as topical ototherapeutics. These conjugates were tested in in vitro assays designed to mirror physiological processes typically ...
Source: Frontiers in Pharmacology - February 15, 2024 Category: Drugs & Pharmacology Source Type: research
Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA regulatory framework
Eur J Pharm Sci. 2024 Feb 12:106726. doi: 10.1016/j.ejps.2024.106726. Online ahead of print.ABSTRACTEMA and FDA are upgrading guidelines on assessing the quality and the equivalence of topically applied drug products for developing copies of originator products and supporting post-marketing variations. For topical products having remarkably similar composition, both EMA and FDA accept the equivalence on the bases of the comparison of rheological properties and in vitro drug release constant (k) and skin permeation flux (J) values, instead of clinical studies. This work aims to evaluate the feasibility to expand this approa...
Source: European Journal of Pharmaceutical Sciences - February 14, 2024 Category: Drugs & Pharmacology Authors: Paola Volont è Umberto M Musazzi Luca Arnaboldi Marco A Ortenzi Antonella Casiraghi Francesco Cilurzo Paola Minghetti Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Compounds Consisting of Quinazoline, Ibuprofen, and Amino Acids with Cytotoxic and Anti-Inflammatory Effects
ChemMedChem. 2024 Feb 14:e202300651. doi: 10.1002/cmdc.202300651. Online ahead of print.ABSTRACTIn this research work, a series of 16 quinazoline derivatives bearing ibuprofen and an amino acid were designed as inhibitors of epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) and cyclooxygenase-2 (COX-2) with the intention of presenting dual action in their biological behavior. The designed compounds were synthesized and assessed for cytotoxicity on epithelial cancer cells lines (AGS, A-431, MCF-7, MDA-MB-231) and epithelial non-tumorigenic cell line (HaCaT). From this evaluation, derivative 6 was observed t...
Source: ChemMedChem - February 14, 2024 Category: Chemistry Authors: Luis Roberto Gardu ño-Villavicencio Ulises Mart ínez-Ortega Elizabeth Ort íz-Sánchez Jos é Manuel Tinajero-Rodríguez Francisco Hern ández-Luis Source Type: research
Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA regulatory framework
Eur J Pharm Sci. 2024 Feb 12:106726. doi: 10.1016/j.ejps.2024.106726. Online ahead of print.ABSTRACTEMA and FDA are upgrading guidelines on assessing the quality and the equivalence of topically applied drug products for developing copies of originator products and supporting post-marketing variations. For topical products having remarkably similar composition, both EMA and FDA accept the equivalence on the bases of the comparison of rheological properties and in vitro drug release constant (k) and skin permeation flux (J) values, instead of clinical studies. This work aims to evaluate the feasibility to expand this approa...
Source: European Journal of Pharmaceutical Sciences - February 14, 2024 Category: Drugs & Pharmacology Authors: Paola Volont è Umberto M Musazzi Luca Arnaboldi Marco A Ortenzi Antonella Casiraghi Francesco Cilurzo Paola Minghetti Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research
NSAIDs do not prevent exercise-induced performance deficits or alleviate muscle soreness: a placebo-controlled randomized, double-blinded, cross-over study
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently consumed by athletes to manage muscle soreness, expedite recovery, or improve performance. Despite the prevalence of NSAID use, their effects on muscle soreness and performance, particularly when administered prophylactically, remain unclear. This randomized, double-blind, counter-balanced, crossover study examined the effect of consuming a single dose of each of three NSAIDs (celecoxib, 200 mg; ibuprofen, 800 mg; flurbiprofen, 100 mg) or placebo 2 h before on muscle soreness and performance following an acute plyometric training session. (Source: Journ...
Source: Journal of Science and Medicine in Sport - February 12, 2024 Category: Sports Medicine Authors: Brandon M. Roberts, Cara E. Sczuroski, Aaron R. Caldwell, Dave J. Zeppetelli, Nathaniel I. Smith, Vincent P. Pecorelli, Jess A. Gwin, Julie M. Hughes, Jeffery S. Staab Tags: Original Research Source Type: research
Evaluating an integrated nano zero-valent iron column system for emerging contaminants removal from different wastewater matrices - Identification of transformation products
In this study, the performance of a column system consisting of zero-valent iron nanoparticles (nZVI) incorporated into a cationic resin and synthesized from green tea extract with the addition of persulfate for the elimination of selected pharmaceuticals and endocrine disruptors from wastewater is evaluated. Ibuprofen, naproxen, diclofenac and ketoprofen were the target pharmaceuticals from non-steroidal anti-inflammatory drugs group, while bisphenol A was the target endocrine disruptor. In this context, different real wastewater effluent matrices were investigated: anaerobic membrane bioreactor (AnMBR), upflow anaerobic ...
Source: Chemosphere - February 10, 2024 Category: Chemistry Authors: Evridiki Barka Maria Christina Nika Andriani Galani Daniel Mamais Nikolaos S Thomaidis Simos Malamis Constantinos Noutsopoulos Source Type: research
