Ibuprofen Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Unleashing the potential of vanillic acid: A new twist on nature's recipe to fight inflammation and circumvent azole-resistant fungal infections
Bioorg Chem. 2024 Mar 1;145:107254. doi: 10.1016/j.bioorg.2024.107254. Online ahead of print.ABSTRACTVanillic acid (VA) - a naturally occurring phenolic compound in plants - is not only used as a flavoring agent but also a prominent metabolite post tea consumption. VA and its associated compounds are believed to play a significant role in preventing diseases, underscoring the need for a systematic investigation. Herein, we report a 4-step synthesis employing the classical organic reactions, such as Willamson's alkylation, Fischer-Spier reaction, and Steglich esterification, complemented with a protection-deprotection strat...
Source: Bioorganic Chemistry - March 3, 2024 Category: Chemistry Authors: Farooq-Ahmad Khan Rimsha Irshad Nimra Tanveer Sana Yaqoob None Razaullah Raza Ali Nida Ali Jafar Saifullah Khwaja Ali Hasan Shahida Naz Abdul Qadir Almas Jabeen Yan Wang Source Type: research

Characterization of microcrystalline cellulose prepared from long and short fibers and its application in ibuprofen tablets
In this study, softwood dissolved pulp was sieved to long fiber (LF) and short fiber (SF), and subsequently to prepare LF-MCC and SF-MCC by hydrochloric acid hydrolysis at different acid dosages (3-7 wt%), reaction times (30-90 min), and temperatures (75-95 °C). The as-obtained MCC products were compared in terms of morphology, size, crystallinity, and chemical structure. The results indicated that the crystallinity and yield of LF-MCC were high, with maximum values of 78.41 % and 98.68 %, respectively. The particle size distribution of SF-MCC was more uniform in the range of 20-80 μm, with a maximum of 59.44 % at 20-80 ...
Source: International Journal of Biological Macromolecules - March 2, 2024 Category: Biochemistry Authors: Xiao Hao Zhongjian Tian Yingchao Wang Zhaoyong Xie Xingxiang Ji Source Type: research

Lower basal and postprandial muscle protein synthesis after 2 weeks single‐leg immobilization in older men: No protective effect of anti‐inflammatory medication
AbstractMuscle inactivity may reduce basal and postprandial muscle protein synthesis (MPS) rates in humans. Anti-inflammatory treatment alleviates the MPS impairments in younger individuals. The present study explored the influence of nonsteroidal anti-inflammatory drugs (NSAIDs) upon MPS during a period of inactivity in older humans. Eighteen men (age 60 –80 years) were allocated to ibuprofen (1200 mg/day, Ibu) or control (Plc) groups. One lower limb was cast immobilized for 2 weeks. Postabsorptive and postprandial MPS was measured before and after the immobilization by L-[ring-13C6]-phenylalanine infusion. The pr...
Source: Physiological Reports - February 26, 2024 Category: Physiology Authors: K. Dideriksen, S. Reitelseder, A. P. Boesen, M. Zillmer, J. Agergaard, M. Kjaer, L. Holm Tags: ORIGINAL ARTICLE Source Type: research

Emerging therapeutic strategies in hypoxic-ischemic encephalopathy: a focus on cognitive outcomes
Perinatal hypoxia-ischemia represents a significant risk to CNS development, leading to high mortality rates, diverse damages, and persistent neurological deficits. Despite advances in neonatal medicine in recent decades, the incidence of HIE remains substantial. Motor deficits can manifest early, while cognitive impairments may be diagnosed later, emphasizing the need for extended follow-up. This review aims to explore potential candidates for therapeutic interventions for hypoxic-ischemic encephalopathy (HIE), with a focus on cognitive deficits. We searched randomized clinical trials (RCT) that tested drug treatments for...
Source: Frontiers in Pharmacology - February 26, 2024 Category: Drugs & Pharmacology Source Type: research

Activated carbon from avocado seed as sorbent phase for microextraction technologies: activation, characterization, and analytical performance
Anal Bioanal Chem. 2024 Feb 23. doi: 10.1007/s00216-024-05203-1. Online ahead of print.ABSTRACTAccording to green analytical chemistry principles, the use of agricultural byproducts as sorbent phases is an interesting topic due to their lignocellulosic origin, as they are biodegradable and inexpensive. To the best of our knowledge, this is the first study in which avocado seed and avocado seed activated carbon are proposed as sustainable sorbents for solid-phase microextraction technologies, which were used to assess the proof of concept. Rotating disk sorptive extraction (RDSE) was used as a model technology and ibuprofen...
Source: Analytical and Bioanalytical Chemistry - February 23, 2024 Category: Chemistry Authors: Alejandra Molina-Balmaceda Valentina Rojas-Candia Daniel Arismendi Pablo Richter Source Type: research

Adsorption of anti-inflammatory and analgesic drugs traces in water on clay minerals
Chemosphere. 2024 Feb 20:141469. doi: 10.1016/j.chemosphere.2024.141469. Online ahead of print.ABSTRACTThe aim of this study was to assess the adsorption of four non-steroidal anti-inflammatory drugs (NSAIDs), namely Paracetamol (PRC), Diclofenac (DIC), Ibuprofen (IBU), and Ketoprofen (KET), using both batch and continuous experiments with clay. Various analytical techniques, including XRD, FTIR, SEM coupled to EDX, and Zeta potential, were employed to characterize both raw and calcined clay. XRD and FTIR analyses confirmed the kaolinite nature of the clay. SEM data revealed a lamellar structure formed in the clay after ca...
Source: Chemosphere - February 22, 2024 Category: Chemistry Authors: Fatma Mansouri Khawla Chouchene Ahmed Wali Jerome Labille Nicolas Roche Mohamed Ksibi Source Type: research

Auricular Acupuncture Prior to Menstruation Can Reduce Primary Dysmenorrhea: A Randomized Controlled Trial
CONCLUSIONS: AA is safe. It may be effective for managing primary dysmenorrhea. Further studies are warranted on AA's effectiveness in diverse populations and extended times.PMID:38380169 | PMC:PMC10874823 | DOI:10.1089/acu.2023.0062 (Source: Acupuncture in Medicine)
Source: Acupuncture in Medicine - February 21, 2024 Category: Complementary Medicine Authors: Dieu-Thuong Thi Trinh An Hoa Tran Quy Thi Nguyen Minh-Man Pham Bui Nguyen Lam Vuong Source Type: research