Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children
Conclusions
Although ablative techniques are feasible and promising treatments for certain pediatric tumors, large multicenter prospective trials will be needed to establish efficacy. (Source: Pediatric Radiology)
Source: Pediatric Radiology - September 25, 2014 Category: Radiology Source Type: research
Update on the new classification of hepatic adenomas: clinical, molecular, and pathologic characteristics.
Conclusions.-Definitive diagnosis of liver mass lesion on needle core biopsies has a decisive role in clinical management. With the advent of the new classification of hepatic adenomas and its prognostic implications, it is vital for pathologists to be aware of the morphologic features seen in different subtypes and the available diagnostic tools, such as immunohistochemistry, to help identify the correct subtype.
PMID: 25076298 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 1, 2014 Category: Laboratory Medicine Authors: Dhingra S, Fiel MI Tags: Arch Pathol Lab Med Source Type: research
[Recurrence of multiple focal nodular hyperplasia in a young male patient].
Abstract
Focal nodular hyperplasia (FNH) is the second most common benign hepatic tumor that is usually found in women. Diagnosis of FNH mainly depends on imaging studies such as color Doppler flow imaging, computed tomography, and magnetic resonance imaging. It is characterized by the presence of stellate central scar and is nowadays incidentally diagnosed with increasing frequency due to advances in radiologic imaging technique. FNH typically presents as a single lesion in 70% of cases and generally does not progress to malignancy or recur after resection. Herein, we report a case of a young male patient...
Source: Korean J Gastroenter... - July 25, 2014 Category: Gastroenterology Authors: Chung E, Park CH, Kim J, Han NI, Lee YS, Choi HJ, Bae SH, Park IY Tags: Korean J Gastroenterol Source Type: research
Single incision laparoscopic hepatectomy: A systematic review
Ioannis D. Gkegkes, Christos IavazzoJournal of Minimal Access Surgery 2014 10(3):107-112Single incision laparoscopic surgery is a rather innovative surgical technique. A systematic literature review was performed with the intention to evaluate the till now clinical evidence regarding the application of single incision technique on liver resections as a method of management in hepatic lesions. Twelve relative studies were found in the field including 30 patients with a age range from 29 to 90 years and a body mass index from 20.1 to 36.5 kg/m 2 . Primary hepatic carcinoma (40%), metastatic nodules (26.7%), hep...
Source: Journal of Minimal Access Surgery - June 20, 2014 Category: Surgery Authors: Ioannis D. GkegkesChristos Iavazzo Source Type: research
Tu1610 Laparoscopic Microwave Ablation (MWA) Is an Efficacious, Novel Modality in the Treatment of Hepatic Adenomas
(Source: Gastroenterology)
Source: Gastroenterology - May 1, 2014 Category: Gastroenterology Authors: Ramanathan Seshadri, Russell C. Kirks, Ryan Z. Swan, John B. Martinie, David A. Iannitti, Mark W. Russo, David Sindram Source Type: research
Hepatocellular carcinoma arising in hepatic adenoma: diagnostic and management implications
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 14, 2014 Category: Pathology Authors: Sandra E. Fischer Tags: Instructive Case Source Type: research
The Occurrence of Primary Hepatic Adenoma in Deceased Donor Renal Transplant Recipient
We reported a case of new-onset, multi-focal hepatic adenoma in an 18 year-old man with no classic risk factors occurring forty months after a renal transplant from a cadaver donor. Histopathology of the adenoma was examined and genotype and phenotype were also analyzed. Histopathologic examination of the adenoma showed no malignancy. Genotype and phenotype analysis revealed no HNF1α or β-catenin gene mutations and no inflammatory infiltration. The patient was well and disease-free postoperatively. Case hypothesis: Hepatic adenoma occurs mostly in those taking oral contraceptives or androgenic-anabolic steroids or in t...
Source: International Braz J Urol - March 14, 2014 Category: Urology & Nephrology Source Type: research
Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions
Summary: Hepatocellular carcinoma (HCC) is one of the most common highly aggressive malignant tumors worldwide. Aldoketoreductase 1B10 (AKR1B10) was first isolated from HCC and further identified to be over-expressed in many cancers from various organs. AKR1B10 contributes to detoxification of xenobiotics by lipid peroxidation and metabolizes physiological substrates such as farnesal, retinal, and carbonyls. Metabolizing these lipid substrates plays a crucial role in promoting carcinogenesis. In the present study, immunohistochemical analysis was performed to determine the prevalence/pattern of AKR1B10 expression in HCC an...
Source: Human Pathology - December 20, 2013 Category: Pathology Authors: Kristina A. Matkowskyj, Han Bai, Jie Liao, Wanying Zhang, Haonan Li, Sambasiva Rao, Reed Omary, Guang-Yu Yang Tags: Original Contributions Source Type: research
Liver diseases in pregnancy: Diseases not unique to pregnancy.
Abstract
Pregnancy is a special clinical state with several normal physiological changes that influence body organs including the liver. Liver disease can cause significant morbidity and mortality in both pregnant women and their infants. Few challenges arise in reaching an accurate diagnosis in light of such physiological changes. Laboratory test results should be carefully interpreted and the knowledge of what normal changes to expect is prudent to avoid clinical misjudgment. Other challenges entail the methods of treatment and their safety for both the mother and the baby. This review summarizes liver d...
Source: World Journal of Gastroenterology : WJG - November 21, 2013 Category: Gastroenterology Authors: Almashhrawi AA, Ahmed KT, Rahman RN, Hammoud GM, Ibdah JA Tags: World J Gastroenterol Source Type: research
Hepatobiliary and pancreatic neoplasms in patients with McCune-Albright syndrome.
Conclusion:We herein describe the first observation of syndromic IPMN and a the new association between McCune-Albright syndrome and pancreatic neoplasms, namely intraductal papillary mucinous neoplasms of the pancreas but also rare hepatobiliary neoplasms including liver adenomas and choledochal cysts. These findings strongly suggest somatic activating GNAS mutations possibly trough cAMP pathway disorders to be involved in the tumorigenesis of hepatobiliary and pancreatic tissues originating from the foregut endoderm, and have lead us to use a routine screening by dedicated MRI including both pancreatobiliary and liver se...
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2013 Category: Endocrinology Authors: Gaujoux S, Salenave S, Ronot M, Rangheard AS, Cros J, Belghiti J, Sauvanet A, Ruszniewski P, Chanson P Tags: J Clin Endocrinol Metab Source Type: research
Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gall Bladder, and Extrahepatic Biliary Tract
Pancreatic neoplasms, including ductal adenocarcinoma, intraductal papillary mucinous neoplasm, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and ampullary carcinoma, are associated with different genetic abnormalities. Liver neoplasms, including hepatic adenomas, hepatocellular carcinomas, and cholangiocarcinomas, are associated with identifiable risk factors and genetic changes. Gall bladder adenomas and adenocarcinomas arise from distinct molecular pathways. The molecular abnormalities seen in these tumors are not used routinely in the molecular diagnostic laboratory. (Source: Cl...
Source: Clinics in Laboratory Medicine - October 11, 2013 Category: Laboratory Medicine Authors: Michael Weindel, Muhammad Zulfiqar, Amarpreet Bhalla, Vinod B. Shidham Source Type: research
Giant hepatocellular adenoma in a child
An 8-year-old female presented with fever, shortness of breath, abdominal pain, and abdominal distention of 2 days duration. Examination was unrevealing except for a large abdominal mass. Abnormal laboratory findings included haemoglobin (8.4g/dl), hematocrit (25.4%), ALT (92U/L), AST (99U/L), and total bilirubin (4.5mg/dl). Computed tomography (coronal view) of the abdomen revealed a large irregular contoured rounded hepatic mass, with areas of mixed density consistent with haemorrhage (). Biopsy of the mass showed well-differentiated hepatocytes without associated bile ducts consistent with hepatic adenoma (). The child ...
Source: Digestive and Liver Disease - September 27, 2013 Category: Gastroenterology Authors: Alley E. Ronaldi, Frances J. Hairston, Henry W. Giles, Michael J. Nowicki Tags: Image of the Month Source Type: research
Resection of a Giant Hepatic Adenoma in an Eight-year-old Girl.
We present the case of a giant hepatic adenoma in an 8-year-old female without established risk factors with progressive abdominal pain, and po intolerance, biliary obstruction, anemia, and fever. Right trisegmentectomy afforded extirpation of the 16 × 14.5 × 8.5 cm mass. The postoperative course was complicated by transient encephalopathy and a bile leak which resolved with appropriate care. The patient is well over 1 year from resection. She demonstrates age appropriate mental and physical function without disease recurrence or complication.
PMID: 24069983 [PubMed - in process] (Source: The American Surgeon)
Source: The American Surgeon - September 1, 2013 Category: Surgery Authors: Morris MW, Berch B, Westmoreland T, Sawaya DE, Blewett CJ Tags: Am Surg Source Type: research
Rupture of a hepatic adenoma in a young woman after an abdominal trauma: A case report.
In conclusion, it is important to consider that abdominal trauma may hide old, asymptomatic and not previously detected injuries, as in the case reported.
PMID: 23885157 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2013 Category: Gastroenterology Authors: Cotta-Pereira RL, Valente LF, De Paula DG, Eiras-Araújo AL, Iglesias AC Tags: World J Gastroenterol Source Type: research
Hepatic adenoma mimicking a metastatic lesion on computed tomography-positron emission tomography scan.
We report the case of a 44-year-old Chinese female patient with a history of cervical adenocarcinoma, referred for a hepatic lesion noted on a surveillance computed tomography (CT) scan. A subsequent CT-PET performed showed a hypermetabolic lesion (standardized uptake value 7.9) in segment IVb of the liver. After discussion at a multi-disciplinary hepato-pancreato-biliary conference, the consensus was that of a metastatic lesion from her previous cervical adenocarcinoma, and a resection of the hepatic lesion was performed. Histology revealed features consistent with a hepatocyte nuclear factor-1 α inactivated steatotic he...
Source: World Journal of Gastroenterology : WJG - July 21, 2013 Category: Gastroenterology Authors: Lim D, Lee SY, Lim KH, Chan CY Tags: World J Gastroenterol Source Type: research
