Liver disease in pregnancy
The presence of abnormal liver function is common in pregnancy. It can be a challenge to elucidate the cause. The history and clinical assessment provide useful tools for distinguishing between pregnancy-related causes, such as pre-eclampsia, acute fatty liver of pregnancy and obstetric cholestasis, and non pregnancy-related causes such as non-alcoholic fatty liver disease, acute viral infection, autoimmune liver disease and Budd–Chiari syndrome. Pregnancy may also affect the natural course of liver conditions, for example, by increasing the risk of haemorrhage from a hepatic adenoma, or the severity of hepatitis E infec...
Source: Medicine - September 24, 2015 Category: Internal Medicine Authors: Charlotte Frise, Catherine Williamson Tags: Mothers, babies and children Source Type: research
Intra-Arterial Therapies for Liver Masses: Data Distilled.
Abstract
The liver is a common site of metastatic and primary disease, as well as a site of benign masses. Given the import of liver containing tumor, its treatment draws from a variety of cancer specialists. Potentially curative options exist for primary and metastatic liver disease; however, advanced disease presentation often prevents cure. The current level of evidence for embolotherapy targeting hepatocellular carcinoma and liver metastatic colorectal cancer is examined, along with intra-arterial treatment options for focal nodular hyperplasia and hepatic adenoma. More specifically, chemoembolization,...
Source: Clinical Colorectal Cancer - September 1, 2015 Category: Cancer & Oncology Authors: Molvar C, Lewandowski RJ Tags: Radiol Clin North Am Source Type: research
Malignant Transformation of Hepatic Adenoma in Glycogen Storage Disease Type-1a: Report of an Exceptional Case Diagnosed on Surveillance Imaging
We report a case of malignant transformation of hepatic adenoma without overexpression of β-catenin in a 31-year-old man with a known glycogen storage disease (GSD) Type-1a, which was diagnosed on surveillance magnetic resonance imaging (MRI). The MRI showed a mild interval increase in one lesion with relative stability of the other adenomas. The lesion was presumed to be suspicious for a hepatocellular carcinoma (HCC) and was confirmed on pathology. (Source: Journal of Clinical Imaging Science)
Source: Journal of Clinical Imaging Science - August 31, 2015 Category: Radiology Authors: Akshay D BahetiMatthew M YehRyan O'MalleyNeeraj Lalwani Source Type: research
Intra-Arterial Therapies for Liver Masses
The liver is a common site of metastatic and primary disease, as well as a site of benign masses. Given the import of liver containing tumor, its treatment draws from a variety of cancer specialists. Potentially curative options exist for primary and metastatic liver disease; however, advanced disease presentation often prevents cure. The current level of evidence for embolotherapy targeting hepatocellular carcinoma and liver metastatic colorectal cancer is examined, along with intra-arterial treatment options for focal nodular hyperplasia and hepatic adenoma. More specifically, chemoembolization, both conventional and dru...
Source: Radiologic Clinics of North America - August 28, 2015 Category: Radiology Authors: Christopher Molvar, Robert J. Lewandowski Source Type: research
Laparoscopic robot-assisted resection of tumors located in posterosuperior liver segments
Abstract
Laparoscopic resection of liver tumors located in the posterosuperior segments is a challenging operation that could be facilitated by robotic assistance. Laparoscopic resection of 12 tumors located in posterosuperior segments (IVa: 1; VII: 5; VIII: 6) was carried out under robotic assistance. All patients had a single tumor nodule. Data were collected prospectively and analyzed retrospectively. Surgery required a mean of 260.4 min (115–430) and was completed laparoscopically in all but one patient, who required conversion to mini-laparotomy because of intolerance of pneumoperitoneum (8.3 %)....
Source: Updates in Surgery - June 15, 2015 Category: Surgery Source Type: research
Multiple liver lesions in a patient with Budd-Chiari syndrome secondary to polycythemia vera.
We present a case of multiple hepatic lesions, suspicious for metastases, in a patient with Budd-Chiari syndrome secondary to polycythemia vera. However, the biopsy findings were consistent with focal nodular hyperplasia. Budd-Chiari syndrome may be associated with multiple nodules of focal nodular hyperplasia, which may be difficult to diagnose radiologically.
PMID: 26019042 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 30, 2015 Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Preliminary Data Using Computed Tomography Texture Analysis for the Classification of Hypervascular Liver Lesions: Generation of a Predictive Model on the Basis of Quantitative Spatial Frequency Measurements—A Work in Progress
Conclusions: Computed tomography texture analysis may prove valuable in lesion characterization. Differentiation between common hypervascular lesion types could be aided by the judicious incorporation of texture parameters into clinical analysis. (Source: Journal of Computer Assisted Tomography)
Source: Journal of Computer Assisted Tomography - May 1, 2015 Category: Radiology Tags: Abdominal Imaging Source Type: research
A triple stain of reticulin, glypican-3, and glutamine synthetase: a useful aid in the diagnosis of liver lesions.
Conclusions .- The triple stain of reticulin, glypican-3, and glutamine synthetae is useful in the differentiation of hepatocellular carcinoma, hepatic adenoma, and focal nodular hyperplasia on biopsy specimens. Furthermore, this triple stain is advantageous to single stains and can help when aberrant staining patterns are observed.
PMID: 25822763 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 1, 2015 Category: Laboratory Medicine Authors: Swanson BJ, Yearsley MM, Marsh W, Frankel WL Tags: Arch Pathol Lab Med Source Type: research
Management of Hepatic Adenomatosis
Abstract
Hepatic adenomatosis (HeAs) is a rare clinical entity defined by the presence of 10 or more hepatic adenomas (HA) within the background of an otherwise normal liver parenchyma, in the absence of glycogen storage disease or anabolic steroid use. HA is a benign tumor associated with oral contraceptive use. Recent advances in pathogenesis and classification of HA have questioned the distinction between these two diseases. HA are currently classified into four different subtypes with genotypic and phenotypic correlation: HNF-1a inactivated HA, B-catenin activated HA, inflammatory HA, and undetermin...
Source: Current Gastroenterology Reports - March 5, 2015 Category: Gastroenterology Source Type: research
Critical appraisal of androgen use in hereditary angioedema: A systematic review.
CONCLUSION: Androgen therapy may be effective for most patients with HAE; however, potential risks and adverse effects must be carefully considered and discussed with patients when considering options for long-term HAE prophylaxis.
PMID: 25707325 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 20, 2015 Category: Allergy & Immunology Authors: Riedl MA Tags: Ann Allergy Asthma Immunol Source Type: research
Primary Hepatic Tumors With Myxoid Change: Morphologically Unique Hepatic Adenomas and Hepatocellular Carcinomas
Mucin production in primary liver neoplasms is typically interpreted as evidence for biliary differentiation. However, we have observed benign and malignant liver tumors that have abundant extracellular myxoid/mucinous material, yet have only evidence of hepatocellular differentiation. To further characterize these unusual findings, 9 cases were identified and further studied. Four cases were hepatic adenomas, whereas 5 were hepatocellular carcinomas. Extracellular myxoid/mucinous material was diffuse in 7 cases and patchy in 2 cases. The extracellular myxoid/mucinous material was typically weakly mucicarmine positive (N=6...
Source: The American Journal of Surgical Pathology - February 14, 2015 Category: Pathology Tags: Original Articles Source Type: research
Lesion discrimination with breath-hold hepatic diffusion-weighted imaging: A meta-analysis.
CONCLUSION: Breath-hold DWI is useful for differentiating between malignant and benign hepatic lesions. The diffusion characteristics of benign lesions that mimic malignant ones have rarely been investigated.
PMID: 25663782 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - February 7, 2015 Category: Gastroenterology Authors: Chen ZG, Xu L, Zhang SW, Huang Y, Pan RH Tags: World J Gastroenterol Source Type: research
Lipids in hepatic glycogen storage diseases: pathophysiology, monitoring of dietary management and future directions
Abstract
Hepatic glycogen storage diseases (GSD) underscore the intimate relationship between carbohydrate and lipid metabolism. The hyperlipidemias in hepatic GSD reflect perturbed intracellular metabolism, providing biomarkers in blood to monitor dietary management. In different types of GSD, hyperlipidemias are of a different origin. Hypertriglyceridemia is most prominent in GSD type Ia and associated with long-term outcome morbidity, like pancreatitis and hepatic adenomas. In the ketotic subtypes of GSD, hypertriglyceridemia reflects the age-dependent fasting intolerance, secondary lipolysis and incre...
Source: Journal of Inherited Metabolic Disease - January 29, 2015 Category: Internal Medicine Source Type: research
Focal liver lesions detection and characterization: The advantages of gadoxetic acid-enhanced liver MRI.
Authors: Palmucci S
Abstract
Since its clinical introduction, several studies in literature have investigated gadolinium ethoxybenzhyl diethylenetriaminepentaacetic acid or gadoxetic acid (Gd-EOB-DTPA) properties. Following contrast injection, it provides dynamic vascular phases (arterial, portal and equilibrium phases) and hepatobiliary phase, the latter due to its uptake by functional hepatocytes. The main advantages of Gd-EOB-DTPA of focal liver lesion detection and characterization are discussed in this paper. Namely, we focus on the possibility of distinguishing focal nodular hyperplasia (FNH) from he...
Source: World Journal of Hepatology - December 2, 2014 Category: Gastroenterology Tags: World J Hepatol Source Type: research
Abstract LB-156: A diet-derived sialic acid promotes inflammation and hepatocellular cancer
In conclusion, Neu5Gc that has metabolically incorporated into tissues from the diet interacts with anti-Neu5Gc antibodies, generating xenosialitis. Potential correlations of human anti-Neu5Gc antibody levels with red meat consumption and cancer risk are being investigated. Methods to flush out the xenogenic Neu5Gc are being pursued. Similar mechanisms may be operative in other chronic inflammatory processes in diseases epidemiologically associated with red meat consumption, such as atherosclerosis.
Citation Format: Annie N. Samraj, Heinz Laubli, Oliver Pearce, Patrick Secrest, Andrea E. Garcia-Bingman, Nissi Varki, Ajit V...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Samraj, A. N., Laubli, H., Pearce, O., Secrest, P., Garcia-Bingman, A. E., Varki, N., Varki, A. Tags: Tumor Biology Source Type: research
