Morphologic and Molecular Findings in Myxoid Hepatic Adenomas
Myxoid hepatic adenomas are a rare subtype of hepatic adenomas with distinctive deposition of extracellular myxoid material between the hepatic plates. A total of 9 cases were identified in 6 women and 3 men with an average of 59±12 years. The myxoid adenomas were single tumors in 5 cases and multiple in 4 cases. In 1 case with multiple adenomas, the myxoid adenoma arose in the background of GNAS-mutated hepatic adenomatosis. Myxoid hepatic adenomas had a high frequency of malignant transformation (N=5 cases). They were characterized at the molecular level by HNF1A inactivating mutations, leading to loss of LFABP protein ...
Source: The American Journal of Surgical Pathology - July 26, 2021 Category: Pathology Tags: Original Articles Source Type: research
Clinical Importance of Incidentally Detected Hyperenhancing Liver Observations on Portal Venous Phase Computed Tomography in Patients Without Known Malignancy or Liver Disease
Conclusions
Incidental hyperenhancing liver observations on portal venous phase CT with homogeneous or typical hemangioma morphology in patients without known cancer or liver disease are highly likely benign. (Source: Journal of Computer Assisted Tomography)
Source: Journal of Computer Assisted Tomography - July 1, 2021 Category: Radiology Tags: Abdominopelvic Imaging: Gastrointestinal Source Type: research
Hepatocellular carcinoma arising within a β-catenin mutated inflammatory hepatic adenoma
Publication date: June 2021Source: Human Pathology: Case Reports, Volume 24Author(s): Christopher M. Chandler, Kevin P. Labadie, James O. Park, Camtu D. Truong (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - April 21, 2021 Category: Pathology Source Type: research
A Multicenter, 10-Year Experience With Hepatocellular Adenoma: Risk Factors and Disease Course
DISCUSSION: This decade-long review analyzing the impact of modifiable risk factors identifies a direct correlation between BMI and hepatocellular adenoma size. Rupture and malignant transformation are rare entities. Cessation of OC appears to be an effective strategy in the management of hepatic adenoma. Further investigations are warranted to determine if addressing modifiable risk factors such as BMI might induce further HA regression.PMID:33861649 | DOI:10.1177/00031348211011084 (Source: The American Surgeon)
Source: The American Surgeon - April 16, 2021 Category: Surgery Authors: Trevor S Silva Michael Sung Daniel W Nelson Andrew L DiFronzo Victoria V O'Connor Source Type: research
A Multicenter, 10-Year Experience With Hepatocellular Adenoma: Risk Factors and Disease Course
DISCUSSION: This decade-long review analyzing the impact of modifiable risk factors identifies a direct correlation between BMI and hepatocellular adenoma size. Rupture and malignant transformation are rare entities. Cessation of OC appears to be an effective strategy in the management of hepatic adenoma. Further investigations are warranted to determine if addressing modifiable risk factors such as BMI might induce further HA regression.PMID:33861649 | DOI:10.1177/00031348211011084 (Source: The American Surgeon)
Source: The American Surgeon - April 16, 2021 Category: Surgery Authors: Trevor S Silva Michael Sung Daniel W Nelson Andrew L DiFronzo Victoria V O'Connor Source Type: research
68. Hemorrhagic shock due to ruptured hepatic adenoma secondary to oral norethindrone acetate in a patient with type 3 von Willebrand disease: a case report
Patients with von Willebrand's disease (vWD) often require menstrual suppression in order to avoid episodes of heavy bleeding. While multiple hormone-based options are appropriate for these patients, specific side effects and clinical considerations based on the type and severity of vWD need further study. We discuss refinement of treatment options for menorrhagia for an adolescent with type 3 vWD who presented with a complication likely related to chronic progestin exposure. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 23, 2021 Category: OBGYN Authors: Preetha Nandi, Kimberly Huhmann, Erin Fee, Andrea Zuckerman Source Type: research
18 F-FDG PET/CT of hepatocellular adenoma subtypes and review of literature
ConclusionHNF1A-mutated HCA may have greater SUV values than inflammatory HCA on 18F-FDG PET/CT exams. However, there are contradictory data in the literature and further investigation is warranted. (Source: Abdominal Imaging)
Source: Abdominal Imaging - February 8, 2021 Category: Radiology Source Type: research
Small Cystic Pancreatic Neuroendocrine Neoplasm with Huge Liver and Bone Metastases.
Authors: Yasuda M, Takeda S, Lee M, Hoshi S, Hoshi T, Tanaka Y, Miyajima S, Takaya H, Kajimura K
Abstract
Pancreatic neuroendocrine neoplasms occasionally have a cystic component. We herein report a case of multiple hepatic tumors, including a huge one and a 24-mm sized pancreatic cystic lesion. The hepatic tumor showed an enhancement pattern consistent with hepatic adenoma. The pancreatic cystic lesion revealed a thickened outside border and a solid inside component, which was enhanced following a contrast study, suggesting cystic pancreatic neuroendocrine neoplasm. Surgical resection was performed. After...
Source: Internal Medicine - December 5, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research
A Cross-Sectional Evaluation of Quality of Life Among Patients with Hepatic Adenomas
(Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - November 18, 2020 Category: Surgery Source Type: research
663 Hepatic Adenoma Masquerading as a Hepatocellular Carcinoma in a Patient With a Fontan Procedure on the Oral Contraceptive Pill
The oral contraceptive pill (OCP) has traditionally been contraindicated in the Fontan circulation due to its thromboembolic profile [1]; though our centre uses it with caution with concomitant anticoagulation. Our case suggests that the OCP may be a potential confounder in Fontan patients with liver lesions and this possibility should be discussed with patients. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 8, 2020 Category: Cardiology Authors: J. Yao, S. Sood, L. Grigg, D. Zentner Source Type: research
