Rare synchronous presentation and development of retroperitoneal dedifferentiated liposarcoma and rectal adenocarcinoma
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Cyrus Parsa, Robert Orlando, Krishna Narayanan, Umakant M. Khetan, Jin Guo, Ravin RupaniAbstractMultiple primary malignancies may occur as synchronous or meta-synchronous tumors in 2–17% of patients. Most multiple primary cancers occur in different locations of the same organ or in other organs such as lung, kidney, prostate, and bone. Occurrence of synchronous colorectal adenocarcinoma with liposarcoma, is exceptionally rare. A 79-year-old male presented with significant weight loss of 2–3 weeks duration following a tra...
Source: Human Pathology: Case Reports - October 11, 2019 Category: Pathology Source Type: research

Post-partum cutaneous manifestation of antiphospholipid syndrome
We describe a female patient that postpartum developed diffuse and rapidly progressing retiform purpura to highlight this atypical presentation noted after delivery. The diagnosis is complicated by the presence of vasculitis with fibrin thrombi in the skin biopsy in the absence of systemic vasculitis. This is of interest because vasculitis is a rare manifestation in antiphospholipid syndrome alone. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - October 11, 2019 Category: Pathology Source Type: research

Hypoplastic kidney with hyperplastic mesonephric remnants as a cause of unilateral non-functioning kidney in an adult male
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Diping Wang, Loren P. Herrera-Hernandez, Mariam P. Alexander (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - September 18, 2019 Category: Pathology Source Type: research

Membranoproliferative glomerulonephritis following tubulointerstitial nephritis is a late manifestation of IgG4-related kidney disease: A distinctive case
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Joichi Usui, Steven P. Salvatore, Mourhege Alsaloum, Alla Goldberg, Sheng Kuo, Surya V. SeshanAbstractIgG4-related kidney disease (IgG4RKD) generally presents as an active and chronic fibrosing tubulointerstitial nephritis. Recent reports have described glomerular lesions, typically with IgG4 containing subepithelial/membranous deposits as part of IgG4RKD. Herein, we report a case of IgG4-related membranoproliferative glomerulonephritis and associated tubulointerstitial nephritis in the clinical setting of IgG4-related autoimmune dise...
Source: Human Pathology: Case Reports - September 14, 2019 Category: Pathology Source Type: research

Hepatoid adenocarcinoma of distal ileum without inflammatory bowel disease; A rare case
We report herein a case of hepatoid adenocarcinoma without inflammatory bowel disease in the distal ileum. A 72-old Japanese female had an ileal tumor with peritoneal dissemination. Partial resection of ileum was performed. The cut surface of the tumor showed a pale-tan-colored solid tumor. Histologically, the tumor consisted trabecular or pseudoglandular proliferation of large polygonal cells, and resembled hepatocellular carcinoma. Thus, metastatic hepatocellular carcinoma was considered with increased serum AFP and PIVKA-II. However, image analysis failed to detect mass lesion in the liver. Hepatoid adenocarcinoma was m...
Source: Human Pathology: Case Reports - September 11, 2019 Category: Pathology Source Type: research

Primary gastric choriocarcinoma with multiple metastases – A case report and literature review of carcinogenesis
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Yiqin Xiong, Michelle X. YangAbstractPrimary gastric choriocarcinoma (PGC) is a rare gastric malignancy that accounts for
Source: Human Pathology: Case Reports - September 10, 2019 Category: Pathology Source Type: research

Combination of both primary pure squamous cell carcinoma (SCC) and conventional invasive lobular carcinoma (ILC) in the same breast; A rare case report and review of the literature
ConclusionPrimary pure SCC of the breast is a rare malignancy which has a rapid rate of growth and a poor prognosis, moreover, ILC has high metastatic rate. Due to rarity of such condition and uncertain treatment modality it should be kept in mind its presence to allow choosing adequate therapy. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - September 10, 2019 Category: Pathology Source Type: research

Two cases of poorly differentiated synovial sarcoma arising from the chest wall - One case of Ewing sarcoma-like small cell type with death 4 years after the first presentation and one case of high-grade spindle cell type receiving postoperative adjuvant chemotherapy
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Akinori Akashi, Yoshitane TsukamotoAbstractWe experienced two cases of poorly differentiated synovial sarcoma (PDSS) arising from the chest wall. The first 42-year-old female patient was asymptomatic, but incidental chest roentgenogram showed a chest wall mass about 5-cm in maximal diameter with extrapleural sign. The chest wall mass was removed at other hospital. A tentative pathological diagnosis was mesothelioma with small cell features. After several courses of chemotherapy consisting...
Source: Human Pathology: Case Reports - August 23, 2019 Category: Pathology Source Type: research

Pituitary mammosomatotroph tumor with folliculo-stellate and mucin cells in a child with McCune Albright syndrome
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Sadeem Al-Subaie, Mussa H. AlMalki, Maqsood Ahmed, Sadeq Al-DandanAbstractA pituitary tumor is a common manifestation of the endocrinopathies criterion in McCune Albright syndrome. Herein, we report a 12-year-old male with McCune Albright syndrome, who presented with dysmorphic features and tall stature, then, underwent a trans-sphenoidal resection of suprasellar lesion that revealed a pituitary mammosomatotroph tumor with a unique finding of folliculo-stellate and mucin cells. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - August 23, 2019 Category: Pathology Source Type: research

Food protein-induced enterocolitis syndrome, an uncommonly encountered pathologic entity
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): C.B. Webb, D.L. Zwick (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - August 10, 2019 Category: Pathology Source Type: research

Colonic malakoplakia in a liver transplant recipient: A case report
We report the case of a 55-year-old male patient who had an orthotropic liver transplant 2 years before presentation and had been taking a combination of tacrolimus and prednisolone. He reported chronic watery diarrhea for the previous 6 months with no history of infection. His colonoscopy showed diffuse multiple mucosal nodules and ulcers appearing in the rectum and throughout the colon. A colonic biopsy revealed infiltration of the lamina propria by chronic inflammatory cells and sheets of histiocytes with the inclusion of Michaelis-Gutmann bodies. Pathological findings were consistent with malakoplakia. This is the ...
Source: Human Pathology: Case Reports - July 25, 2019 Category: Pathology Source Type: research

Pseudochylothorax: An underdiagnosed entity
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Richa Pawar, Sucheta, Renuka Verma, Sant Prakash Kataria (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - July 13, 2019 Category: Pathology Source Type: research

Unexpected DOG1 expression in gastrointestinal neuroectodermal tumor of the rectum: A diagnostic pitfall
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Cindy Bossenmeyer, Emilie Duchalais, Anne Moreau, Céline Bossard (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - July 4, 2019 Category: Pathology Source Type: research

Tropheryma whipplei endocarditis presenting as chronic valvular disease: A case report and review of literature
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Julia R. Naso, Davie Wong, Daniel R. Wong, Chien-Hung Chen, Linda M.N. HoangAbstractWhipple's endocarditis is a rare but treatable infectious disease. We discuss the diagnostic work-up of a case lacking classic endocarditis features. Current challenges in diagnosis and treatment of this under-recognized infection are highlighted. This case underscores the necessity of considering Whipple's endocarditis in the differential diagnosis for chronic valvular disease. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 29, 2019 Category: Pathology Source Type: research

Unusual neuroma of the adrenal medulla mimicking schwannoma and coexisting with an adrenocortical adenoma
We report an extremely rare case of incidentaloma in the adrenal medulla that was pathologically detected in an adrenal gland resected for cortical adenoma. The tumor in the medulla, measuring 5 mm in diameter, consisted of interlacing fascicles of Schwann cells and resembled a schwannoma. However, the tumor exhibited a very irregular contour and contained abundant nerve fiber bundles, which were positively immunostained for neurofilament protein, leading to the final diagnosis of neuroma. Although neural hypertrophy is rarely seen in the adrenal medulla, neuroma of the adrenal medulla has not been reported. We demonstra...
Source: Human Pathology: Case Reports - June 28, 2019 Category: Pathology Source Type: research

Metastatic well-differentiated neuroendocrine tumor in the breast: A case report and literature review
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Dongfang Yu, Yi ZhouAbstractMetastatic well-differentiated neuroendocrine tumors in the breast are rare and can be mistaken as invasive breast carcinoma due to their overlapping clinical, histological or radiological features. A 49-year-old female presented for evaluation of a left breast mass. Her past medical history was significant for an ileal well-differentiated neuroendocrine tumor with liver metastasis. Histology of breast biopsy shows nests of small uniform tumor cells with regularly dispersed chromatin. The tumor cells are p...
Source: Human Pathology: Case Reports - June 22, 2019 Category: Pathology Source Type: research

Blastic transformation of mantle cell lymphoma with B-lymphoblastic features
We present a case of mantle cell lymphoma with the typical phenotype, which transformed to a blastic morphology with loss of expression of CD20, CD5 and BCL2, and gain of CD10 and TdT. In cases presenting with blastic morphology, the use of CD10 and TdT in addition to the usual mantle cell lymphoma markers is essential since cases of mantle cell lymphoma with B-lymphoblastic features may require innovative treatment. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 20, 2019 Category: Pathology Source Type: research

Perineal nuchal-type fibroma originated from perirectal region: A case report
We report a 58-year-old man who presented with perineal nuchal-type fibroma originating in the perirectal region. This tumor was surgically excised; however, the fibrous band from tumor reached into levator ani muscle and was resected incompletely. Continuous follow up is needed even though this tumor is benign. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 20, 2019 Category: Pathology Source Type: research

Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Afnan Elsayed, Haneen Al-Maghrabi, Hosam Alardati, Ameen Alherabi, Abdelrazak Meliti (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 19, 2019 Category: Pathology Source Type: research

Small bowel obstruction exacerbated by barium sulfate administration
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Whitney L. Reid, Jesse L. Cox, Karen L. Pennington, Philip McCarthy, Vishal M. Kothari, Samuel M. CohenAbstractSmall bowel obstruction (SBO) is a commonly encountered medical condition, typically a result of extrinsic causes, including post-operative adhesions. Less frequently, intrinsic and intraluminal factors may cause obstruction. Barium sulfate is a widely used contrast agent for radiography of suspected SBO, though it is rarely encountered in histologic sections and is an uncommon cause of SBO. Here, we present a case of a pati...
Source: Human Pathology: Case Reports - June 19, 2019 Category: Pathology Source Type: research

Langerhans Cell Histiocytosis, Non-Langerhans histiocytosis and concurrent Papillary Thyroid Carcinoma with BRAF V600E mutations: A case report and literature review
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Laura Wake, Liqiang Xi, Mark Raffeld, Elaine S. Jaffe (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 19, 2019 Category: Pathology Source Type: research

Metanephric adenoma with osseous metaplasia and bone marrow elements
We present a case of a 75-year-old woman diagnosed with a metanephric adenoma with the unusual finding of associated bone and bone marrow elements. To our knowledge, this is the first case report of bone marrow elements seen in association with metanephric adenoma. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 14, 2019 Category: Pathology Source Type: research

Vasculitis manifested with multiple mass lesions in kidneys, lungs and soft tissue, mimicking malignant tumors
We report a case of granulomatosis with polyangiitis (GPA) (Wegner's granulomatosis) who presented with multiple mass lesions in kidneys and lung lobes, as well as neck soft tissue, mimicking malignancies. This 71-year-old woman initially presented with sudden right foot drop, left calf pain and right eye vision loss. She was treated with corticosteroid for the diagnosis of possible temporal arteritis. Months after steroid was tapered to 2 mg per day, she developed increasing fatigue, weight loss, and shortness of breath. CT scan showed lung mass lesions in left upper lobe (3.8 × 2.4 cm), right mid lung with ...
Source: Human Pathology: Case Reports - June 11, 2019 Category: Pathology Source Type: research

Adult Langerhans cell histiocytosis arising in colonic polyp: A case report and literature review
In this report, we present a case of an adult female who was found to have a cecal polyp on a routine screening colonoscopy. The histopathological examination and immunohistochemical studies confirmed the diagnosis of LCH. We also review the literature of adults LCH manifested in GI mostly colonic polyps. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 7, 2019 Category: Pathology Source Type: research

A case of clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) with two EWSR1-ATF1 fusions
We report a case of CCSLGT with two fusion transcripts of EWSR1-ATF1. A 60-year-old female received ileectomy because of repeated ileus history. A 30-mm submucosal tumor with mucosal ulceration was detected in the ileum. Histologically, sarcomatous tumor comprised relatively monomorphic tumor cells arranged in sheets or nests and several multinucleated osteoclast-like giant cells. The main tumor cells contain small round nuclei with prominent nucleoli and abundant clear cytoplasm. Immunohistochemistry, the tumor cells expressed S-100 protein diffusely and focally expressed CAM5.2, EMA, and CD56. They did not express HMB-45...
Source: Human Pathology: Case Reports - June 6, 2019 Category: Pathology Source Type: research

Anaplastic diffuse leptomeningeal glioneuronal tumor associated with H3 K27M mutation
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Shoh Sasaki, Takanori Hirose, Sumihito Nobusawa, Tomoya Myojin, Kohei Morita, Tokiko Nakai, Junko Hirato, Chiho Ohbayashi (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - May 25, 2019 Category: Pathology Source Type: research

Multilocular cystic renal neoplasm of low malignant potential extending into the perinephric adipose tissue
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Khaled Abdelfattah Murshed, Mohammed Akhtar, Mohamed Ben-GashirAbstractMultilocular cystic renal neoplasm of low malignant potential (MCRNLMP) is a rare variant and a distinct subtype of clear cell renal cell tumors that has a favorable outcome. Most of the cases present with a low pathologic stage at diagnosis (T1 or T2). It is unusual for this tumor to extend into the perinephric adipose tissue, renal sinus fat or renal vein. There are very few cases reported in the literature to have a higher pathologic stage (pT3 and above) at di...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research

The diagnostic value of detection of high-risk HPV in differentiating primary bladder cancer versus uterine cervical cancer involving bladder - A case report
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Haiying Zhan, Elizabeth Korangy, Ying HuangAbstractUterine cervical cancer can invade the urinary bladder at an advanced stage. Distinguishing between primary urothelial carcinoma and secondary carcinoma involving the bladder is extremely important because these two clinical settings have completely different management and prognosis. It can be very challenging for pathologists to determine the tumor origin, since the carcinomas in bladder and cervix have overlapping histological features and immunohistochemical profiles. Here we rep...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research

Monophasic epithelial synovial sarcoma initially diagnosed as metastatic adenocarcinoma of unknown primary
We report a case of monophasic epithelial synovial sarcoma, which was initially diagnosed as metastatic adenocarcinoma. A 45-year-old woman presented with a tender pelvic mass, whose morphology was consistent with a glandular neoplasm. The mass was misdiagnosed as metastatic adenocarcinoma of unknown primary, and was treated as such. The tumor recurred 12 years later; it showed biphasic morphology including glandular and spindle sarcomatoid components. TLE1 immunoreactivity of the second tumor supported diagnosis of biphasic synovial sarcoma. The original lesion was reexamined and revealed very focal minor spindle tumor ...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research

Primary intestinal NK-cell lymphoma, EBV-negative: A case report and literature review
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Matthew Koo, Olga Olevsky, Kathleen Ruchalski, Sophie SongAbstractPrimary intestinal NK-cell lymphoma (PINKL) is a rare entity with an overall poor prognosis. It is frequently EBV-positive and is characteristically negative for a T-cell gene rearrangement. Some parameters that may confer a relatively good prognosis include unifocality, the absence of intestinal perforation, and possibly EBV negativity. While exceedingly rare case reports of EBV-negative PINKL are available in the literature, the NK-cell phenotype of these lymphomas i...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research

Extranodal Rosai-Dorfman disease of the kidney: A case report
We present a case of extranodal RDD of the kidney. Imaging revealed a nodular lesion in the right renal pelvis, with accompanying pelvic dilation and parenchymal atrophy, reminiscent of immunoglobulin G4 (IgG4)-related disease. With the clinical diagnosis of suspected renal pelvic cancer, laparoscopic right nephrectomy was performed. Macroscopic findings showed a mass with a white-tan cut surface. Histological examination revealed histiocytes with emperipolesis and patchy infiltration of plasma cells, lymphocytes and foamy macrophages in a fibrocollagenous stroma. Immunohistochemically, the histiocytes were positive for S1...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research

Malignant myoepithelioma of the breast (MMB); An interesting case report with pathological, immunohistochemical findings and review of literature
ConclusionsMMB is extremely rare entity which showed be suspected during differential diagnosis of any malignant spindle cell tumor of the breast. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research

Whole transcriptome analysis identifies upregulated genes and pathways in ductal carcinoma in situ mimicking usual ductal hyperplasia
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Jennifer Zeng, Jonathan Serrano, Matija Snuderl, Farbod Darvishian (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - May 20, 2019 Category: Pathology Source Type: research

EBV positive extranodal NK/T cell lymphoma presenting as intestinal lymphoma- A diagnostic challenge
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Nitya Prabhakaran, Katsiaryna Laziuk, Richard D. HammerAbstractThe World Health Organization (WHO) recognizes aggressive natural killer (NK)-cell leukemia and extranodal NK/T-cell lymphoma, nasal type as Epstein Barr Virus (EBV) associated lymphoproliferative disorders that may have overlapping features and must be distinguished from other T-cell lymphomas. A 35-year-old Hispanic female presented with fever of unknown origin, hemolysis and pancytopenia. Bone marrow biopsy with flow cytometry was negative for malignancy. Jejunal resec...
Source: Human Pathology: Case Reports - May 19, 2019 Category: Pathology Source Type: research

Large pleomorphic carcinoma of the lung: A case report
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Rusella Mirza, Mingxia ShiAbstractPleomorphic carcinoma (PC) of the lung is an aggressive carcinoma and an extremely rare entity. It is one of the subtypes of pulmonary sarcomatoid carcinoma. We are presenting a case of large PC with the relevant histological, immunohistochemical and molecular studies. A surgical specimen of a lung mass was obtained from a 74 year old female patient. The mass was 11 cm in its greatest dimension and was firmly attached to the pleura and diaphragm. Grossly the tumor was infiltrating to the surrounding s...
Source: Human Pathology: Case Reports - May 17, 2019 Category: Pathology Source Type: research

Dibothriocephalus nihonkaiensis infection identified by pathological and genetic analyses -a case report and a recent literature review of human diphyllobothriasis
We report a 20-year-old male with a past history of diarrhea and discharge of a strobila of a broad tapeworm from his anus 3 months ago. He again noticed passing a tapeworm strobila and he visited our hospital with the tapeworm sample. The macroscopic appearance and the pathological features strongly suggested Diphyllobothriasis. Soon after the first visit to our hospital, a capsule endoscopy was performed with the result of no evidence of strobilae or scoleces. Praziquantel at 20 mg/kg was orally administered once. Before drug administration, egg-like structures were present in the stool. They disappeared soon after d...
Source: Human Pathology: Case Reports - May 13, 2019 Category: Pathology Source Type: research

Incidental neuroendocrine tumor of the esophagus: A case report and review of the literature
We present a case of a 71 year old female with a history of Barrett's esophagus with high grade dysplasia that on screening endoscopy was found to have a squamous patch proximal to the gastroesophageal junction and underwent an endoscopic mucosal resection. Within the resection, there was a small tumor with a monomorphic population with speckled nuclear chromatin located within the lamina propria extending into the muscularis mucosae. The tumor measured 1 mm in greatest dimension and the overlying epithelium showed no evidence of the presence of Barrett's esophagus. Immunohistochemical staining of the tumor was consist...
Source: Human Pathology: Case Reports - May 11, 2019 Category: Pathology Source Type: research

Intramural great vessel lymphoma presenting as thrombus in an aortic aneurysm
We present the case of a 72-year-old man who presented with severe abdominal pain and was found to have thrombosed abdominal aortic aneurysm. The retrieved thrombus showed Epstein Barr virus-positive large B cell lymphoma (LBCL). Post-operative Echocardiography, Computerized tomography (CT) and Positron Emission Tomography (PET) scan did not show any residual tumor focus, abnormal mass or thickening, increased FDG uptake or hypermetabolism (Nodal or extranodal). This is the first case of large B cell lymphoma presenting as a thrombus within abdominal aortic aneurysm and third case of intramural great vessel lymphoma. (Sour...
Source: Human Pathology: Case Reports - March 11, 2019 Category: Pathology Source Type: research

“Circulating lobular breast carcinoma masquerading as acute leukemia”
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Meredith M. Nichols, Luis Malpica, Hyman B. Muss, Nathan D. Montgomery (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 27, 2019 Category: Pathology Source Type: research

Late isolated metastasis of colon adenocarcinoma to the right ventricle
We present an exceedingly rare case of solitary metastasis of mucinous adenocarcinoma occupying 80% of the right ventricle and involving tricuspid valve, discovered 17 years after a diagnosis and treatment of a colon cancer. The patient's clinical presentation, diagnosis, and surgical management are detailed. This case provides evidence that late metastasizing colonic carcinoma and ventricular location of metastasis can and do occur. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 27, 2019 Category: Pathology Source Type: research

Synaptophysin-positive nested stromal-epithelial tumor (NSET) of the liver in a 13-year-old male: A case report
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Zongshan Lai, Wei Li, Zakaria Aqel, Jacqueline K. MacknisAbstractNested stromal-epithelial tumor (NSET) of the liver is an extremely rare, newly described, nonhepatocytic, nonbiliary tumor of the liver with less than 40 cases reported in the literature to date [1].This tumor affects predominantly pediatric patients (2–34 years, mean age: 15.2 years, 69% female predominance). Imaging typically discloses a circumscribed heterogenous mass with foci of calcification. NSET has great clinical, radiologic and histologic overlap with many...
Source: Human Pathology: Case Reports - February 27, 2019 Category: Pathology Source Type: research

Rapidly progressive therapy-related myeloid neoplasm in a patient treated for Burkitt lymphoma: A case report
We present a case of a 44-year-old female who initially presented with Stage 4b, EBV-negative BL with classic morphological, immunophenotypic and cytogenetic features. The patient was treated with standard CODOX-M/IVAC chemotherapy (Cyclophosphamide, Doxorubicin, Vincristine, Methotrexate, Leucovorin, Ifosfamide, Etoposide, Cytarabine) plus Rituximab and achieved complete remission. She subsequently presented 2 years later with a t-MN which progressed to acute myeloid leukemia within 4 months.Fluorescence in situ hybridization studies (FISH) and cytogenetic studies post chemotherapy showed an abnormal mosaic female kar...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research

An indolent pancreatic ductal adenocarcinoma with psammoma bodies and a coincidental neuroendocrine tumor
In this report we will discuss a case of a very slow-growing pancreatic ductal adenocarcinoma arising in the neck/body with a coincidental neuroendocrine tumor in the tail. Prominent psammoma bodies are observed in the ductal carcinoma (absent in the neuroendocrine tumor). The presence of psammoma bodies within an indolent pancreatic ductal adenocarcinoma is very unusual and suggests a possible association with a favorable clinical course. Further study would be warranted to make a firm conclusion. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research

Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review
We report a case of fibrocartilaginous mesenchymoma (FCM) with multicystic changes in the fibrous component within the tumor, although the fibrous component usually shows cellular proliferation of spindle cells in the background of collagen fascicles. A 16-year-old boy complained of right knee pain after physical examination for several months. A bone tumor in the right proximal tibia was incidentally detected by plain radiography after a traffic accident. A surgical specimen obtained after enblock resection revealed irregular cartilaginous islands with enchondral ossification within the fibrous background and dominant cys...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research

Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Taisei Kurihara, Yoshiyuki Suehara, Keisuke Akaike, Takuo Hayashi, Taketo Okubo, Youngji Kim, Tatsuya Takagi, Kazuo Kaneko, Takashi Yao, Tsuyoshi SaitoAbstractAn 80-year-old man was diagnosed with squamous cell carcinoma (SCC) arising from chronic osteomyelitis in his right femur. The pathological findings of the amputated leg showed ulcerated tumor extending from the skin to the medullary cavity of the right femur in a continuous fashion. Metastasis in the left clavicle was also noticed 6 months after surgery, and the patient ultimatel...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research

Carcinoma of the dorsum of the tongue with lung carcinoma and duodenal carcinoma in one patient
We present a case of SCC of the dorsum of the tongue along with the development of two other primary cancers with different histologies in a 61-year-old Japanese woman, who presented with a mass on the dorsum of her tongue in 2017. Intraoral examination revealed a 2.5 × 1.5-cm tumor on the dorsum of the tongue without induration and covered with normal epithelium. She was previously diagnosed with carcinoma in an adenoma of the duodenum in 2013 and adenocarcinoma of the right lung in 2016. Computed tomography and magnetic resonance imaging revealed no evidence of malignant tumors in the head and neck region. The ...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research

High-grade transformation of papillary cystadenocarcinoma with p16 immunoreactivity arising from the base of tongue
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Katherine Larrabee, Jena C. Patel, Terrance J. Lynn, Iman Sarami, William QuinonesAbstractPapillary cystadenocarcinoma (PCC) is a rare malignant salivary gland neoplasm that accounts for less than 0.2% of primary salivary gland tumors. These tumors are characterized by the presence of invasive cystic and ductal structures and well-defined papillary endophytic projections with or without mucin production. PCC are generally low-grade indolent tumors with relatively low rate of regional lymph node metastasis. Since malignant tumors are rare,...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research

Gluteal region spindle cell variant embryonal rhabdomyosarcoma in infant treated with buttockectomy
ConclusionThe spindle cell embryonal rhabdomyosarcomas is a rare variant of embryonal subtype of RMS, occurring more commonly in children and adolescents. Its less aggressive sarcoma and better prognosis in children or adolescents, establish the correct diagnosis crucial using combination of clinical finding, histopathology and Immunohistochemistry. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - January 25, 2019 Category: Pathology Source Type: research

Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone
We report the case of a 78-year-old female with HCDD who was successfully treated with bortezomib and dexamethasone (BD); histopathological improvements were confirmed by kidney biopsy after 2 years of chemotherapy. She presented with renal insufficiency, proteinuria, hematuria, hypogammaglobulinemia, and hypocomplementemia. Renal biopsy showed diffuse global nodular glomerulopathy with the deposition of IgG1 and C3 in the glomeruli and on the tubular basement membrane. Kappa and lambda light chains were not detected. Staining for the constant regions of the gamma heavy chain revealed the absence of the CH1 domain. These...
Source: Human Pathology: Case Reports - January 17, 2019 Category: Pathology Source Type: research

Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
Publication date: March 2019Source: Human Pathology: Case Reports, Volume 15Author(s): Sara Makhdoum, M. Ruhul Quddus, Michele M. Lomme, Katrine Hansen, W. Dwayne LawrenceAbstractA 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique morphologic patterns with no overlap or transition from one pattern to the other. The low-grade component consisted of FIGO grade 1 endometrioid adenocar...
Source: Human Pathology: Case Reports - January 8, 2019 Category: Pathology Source Type: research