Reply to: "Indication of Percutaneous Microwave Ablation for the Treatment of Hepatic Adenomas: Squaring the Circle"
This study reported on the results of percutaneous microwave (MW) ablation for the treatment of hepatocellular adenomas (HCAs). These tumors are benign but are at risk for bleeding and malignant transformation. Therefore, surgery is indicated in selected cases to prevent such complications. The same rationale was used by the authors, and, in their study (1), all HCAs could be successfully ablated after a maximum of two ablation sessions, without significant complications. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - May 31, 2016 Category: Radiology Authors: Maxime Ronot, Valérie Vilgrain Tags: Letter to the Editor Source Type: research
Indication of Percutaneous Microwave Ablation for the Treatment of Hepatic Adenomas: Squaring the Circle
This study reported on the results of percutaneous microwave (MW) ablation for the treatment of hepatocellular adenomas (HCAs). These tumors are benign but are at risk for bleeding and malignant transformation. Therefore, surgery is indicated in selected cases to prevent such complications. The same rationale was used by the authors, and, in their study (1), all HCAs could be successfully ablated after a maximum of two ablation sessions, without significant complications. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - May 31, 2016 Category: Radiology Authors: Maxime Ronot, Valérie Vilgrain Tags: Letter to the Editor Source Type: research
Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss
; Michael W Cruise (Source: Modern Pathology)
Source: Modern Pathology - May 30, 2016 Category: Pathology Authors: Rondell P GrahamLuigi M TerraccianoAlexander MevesPatrick M VanderboomSurendra DasariMatthew M YehMichael S TorbensonMichael W Cruise Source Type: research
Synchronous giant hepatic adenoma in siblings-A case report and brief literature review.
Abstract
A 47-year-old woman was referred to our department for a hepatic mass. She denied history of hepatitis or alcohol consumption and regular oral contraceptive use, except for the emergency contraceptive pill taken once a decade ago. Hepatitis B surface antigen and anti-hepatitis C antibody were negative, α-fetoprotein was within normal limit. CT scan revealed an enormous mass measuring 26.0×16.5×13.0 cm that almost totally replaced the right hepatic lobe. The neoplasm was completely resected and pathologically diagnosed as hepatic adenoma. Literature review indicates this is the largest hepatic ...
Source: Cancer Biology and Therapy - April 19, 2016 Category: Cancer & Oncology Authors: Zhang C, Shi X, Zhao L Tags: Cancer Biol Ther Source Type: research
Rapid height growth after liver transplantation in adulthood.
Abstract
Glycogen storage disease Ib is a rare, inherited metabolic disorder caused by glucose-6-phosphatase translocase deficiency. Its main symptoms are hypoglycemia, hyperlipidemia, neutropenia, hepatomegaly, liver adenomas and short stature. The exact mechanism of short stature in this disease is unclear, the most feasible possibility is that it is caused by impairment of growth-hormone and insulin-like growth factor I axis. Here we report the case of a patient who showed typical symptoms of glycogen storage disease Ib since his infancy, his height being under 1 percentile since then. Later-developed h...
Source: Growth Hormone and IGF Research - March 18, 2016 Category: Endocrinology Authors: Szili B, Görög D, Gerlei Z, Győri G, Lakatos P, Takács I Tags: Growth Horm IGF Res Source Type: research
Hepatocellular Neoplasms Arising in Association With Androgen Use
Correlation between androgen use and hepatocellular neoplasia is well established. However, there are no detailed studies of the histopathology and immunohistochemical/molecular profile of these tumors. We studied 9 patients with androgen-associated hepatocellular neoplasms. In addition to histology, immunostains for liver fatty acid–binding protein, β-catenin, glutamine synthetase, C-reactive protein, and serum amyloid A were utilized for tumor subtyping. Molecular testing using Solid Tumor Targeted Cancer Panel was performed on 3 cases. The neoplasms were predominantly seen in male individuals (7/9). Two patients (22%...
Source: The American Journal of Surgical Pathology - March 16, 2016 Category: Pathology Tags: Original Articles Source Type: research
Hepatic Adenomas in Adolescents with Endometriosis Treated with Norethindrone Acetate
Endometriosis—the implantation of endometrial-like tissue outside of the uterus— affects approximately 10% of female adolescents and adults, who often experience pain and infertility. First-line medical treatment includes treatment with progesterone-only or combined oral contraceptive pills. Estrogen-containing contraceptives are associated with increased risk of hepatic adenomas (3-4 per 100,000), which can cause life-threatening hemorrhage1. Association of progesterone-only medications with hepatic adenomas has not been reported, though peripheral conversion of norethindrone acetate (NET-A) to ethinyl estradiol—at ...
Source: Journal of Pediatric and Adolescent Gynecology - February 19, 2016 Category: OBGYN Authors: P.C. Brady, S.A. Missmer, M.R. Laufer Source Type: research
Natural Progression of Canine Glycogen Storage Disease Type IIIa.
Abstract
Glycogen storage disease type IIIa (GSD IIIa) is caused by a deficiency of glycogen debranching enzyme activity. Hepatomegaly, muscle degeneration, and hypoglycemia occur in human patients at an early age. Long-term complications include liver cirrhosis, hepatic adenomas, and generalized myopathy. A naturally occurring canine model of GSD IIIa that mimics the human disease has been described, with progressive liver disease and skeletal muscle damage likely due to excess glycogen deposition. In the current study, long-term follow-up of previously described GSD IIIa dogs until 32 mo of age (n = 4) a...
Source: Comparative Medicine - February 19, 2016 Category: Zoology Authors: Brooks ED, Yi H, Austin SL, Thurberg BL, Young SP, Fyfe JC, Kishnani PS, Sun B Tags: Comp Med Source Type: research
Laparoscopic Anatomical Left Hepatectomy for Intrahepatic Bile Duct Papillary Mucinous Cystadenoma With Intraoperative Vascular Repair: A Case Report
Abstract: Laparoscopic hepatectomy has been widely performed for patients with benign liver tumors such as hepatic hemangioma, focal nodular hyperplasia, and hepatic adenoma.
We here present a case of a 78-year-old female patient who was initially admitted to our department due to fever and jaundice for 2 days. Abdominal enhanced computed tomography scan showed intrahepatic and extrahepatic bile duct dilatation with liver atrophy of left lobe. Unenhanced nodules were seen within the left intrahepatic bile duct. Ultrasonography revealed intrahepatic and extrahepatic bile duct dilatation with viscous fluid, tubular adenoma?...
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Young Female Patient With a Hepatic Adenoma: Determining Risk for Malignant Transformation
Which immunophenotype is associated with the greatest risk for malignant transformation in hepatic adenoma? (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - February 1, 2016 Category: Internal Medicine Authors: Sounak Gupta, Lori A. Erickson Tags: Path to patient image quiz Source Type: research
Microwave Ablation for the Treatment of Hepatic Adenomas
Microwave (MW) ablation was used to treat 12 hepatocellular adenomas in six patients (five women and one man; mean age, 39.6 y). Mean treated tumor size was 2.7 cm ± 2.0. Tumor response was evaluated with serial cross-sectional imaging for a mean follow-up of 12.6 months ± 7.1. Primary treatment effectiveness and local tumor control were 100%. There were no instances of hemorrhage, malignant transformation, new hepatic tumors, or extrahepatic metastases. This early experience of treatment of hepatic adenomas by MW ablation demonstrates it to be a safe and feasible treatment modality at short-term follow-up. (Source: Jour...
Source: Journal of Vascular and Interventional Radiology : JVIR - January 30, 2016 Category: Radiology Authors: Amanda R. Smolock, Mircea M. Cristescu, Theodora A. Potretzke, Timothy J. Ziemlewicz, Meghan G. Lubner, J. Louis Hinshaw, Christopher L. Brace, Fred T. Lee Tags: Brief Report Source Type: research
Microwave Ablation for the Treatment of Hepatic Adenomas
Publication date: February 2016 Source:Journal of Vascular and Interventional Radiology, Volume 27, Issue 2 Author(s): Amanda R. Smolock, Mircea M. Cristescu, Theodora A. Potretzke, Timothy J. Ziemlewicz, Meghan G. Lubner, J. Louis Hinshaw, Christopher L. Brace, Fred T. Lee Microwave (MW) ablation was used to treat 12 hepatocellular adenomas in six patients (five women and one man; mean age, 39.6 y). Mean treated tumor size was 2.7 cm ± 2.0. Tumor response was evaluated with serial cross-sectional imaging for a mean follow-up of 12.6 months ± 7.1. Primary treatment effectiveness and local tumor contro...
Source: Journal of Vascular and Interventional Radiology - January 30, 2016 Category: Radiology Source Type: research
Prevalence of benign focal liver lesions: ultrasound investigation of 45,319 hospital patients
Conclusions
The calculated prevalence of benign focal liver lesions shows that on the fortuitous discovery of space-occupying lesions of the liver, first consideration should be given to focal fatty sparing, simple hepatic cysts and hemangiomas. The finding of a FNH or an adenoma is rarely a random discovery. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 13, 2016 Category: Radiology Source Type: research
Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children
Conclusion
Non-cardiovascular findings were seen in 16.5% of cardiovascular MRI studies in children, of which 2.2% were clinically significant findings. Prevalence and nature of these non-cardiovascular findings are different from those reported in adults. Attention to these findings is important during interpretation. (Source: Pediatric Radiology)
Source: Pediatric Radiology - January 11, 2016 Category: Radiology Source Type: research
A single centre experience of first "one hundred laparoscopic liver resections".
Conclusions. LLR is a safe and oncologically feasible procedure with comparable short-term perioperative outcomes to the open approach. However, further studies are necessary to determine long-term oncological outcomes.
PMID: 24672143 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
