Discovering common pathogenic processes between COVID-19 and HFRS by integrating RNA-seq differential expression analysis with machine learning
This study is attributed to the identification of common genes and perturbed pathways by combining differential expression analysis with bioinformatics and machine learning approaches. Initially, the transcriptomic data of hantavirus-infected peripheral blood mononuclear cells (PBMCs) and SARS-CoV-2 infected PBMCs were analyzed through differential gene expression analysis for identification of common differentially expressed genes (DEGs). The functional annotation by enrichment analysis of common genes demonstrated immune and inflammatory response biological processes enriched by DEGs. The protein–protein interaction (P...
Source: Frontiers in Microbiology - May 5, 2023 Category: Microbiology Source Type: research
Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics
Antiviral Res. 2023 May 3;214:105619. doi: 10.1016/j.antiviral.2023.105619. Online ahead of print.ABSTRACTSeoul virus (SEOV) is an emerging global health threat that can cause hemorrhagic fever with renal syndrome (HFRS), which results in case fatality rates of ∼2%. There are no approved treatments for SEOV infections. We developed a cell-based assay system to identify potential antiviral compounds for SEOV and generated additional assays to characterize the mode of action of any promising antivirals. To test if candidate antivirals targeted SEOV glycoprotein-mediated entry, we developed a recombinant reporter vesicular ...
Source: Antiviral Research - May 4, 2023 Category: Virology Authors: Punya Shrivastava-Ranjan Shilpi Jain Payel Chatterjee Joel M Montgomery Mike Flint C ésar Albariño Christina F Spiropoulou Source Type: research
Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics
Antiviral Res. 2023 May 3;214:105619. doi: 10.1016/j.antiviral.2023.105619. Online ahead of print.ABSTRACTSeoul virus (SEOV) is an emerging global health threat that can cause hemorrhagic fever with renal syndrome (HFRS), which results in case fatality rates of ∼2%. There are no approved treatments for SEOV infections. We developed a cell-based assay system to identify potential antiviral compounds for SEOV and generated additional assays to characterize the mode of action of any promising antivirals. To test if candidate antivirals targeted SEOV glycoprotein-mediated entry, we developed a recombinant reporter vesicular ...
Source: Antiviral Research - May 4, 2023 Category: Virology Authors: Punya Shrivastava-Ranjan Shilpi Jain Payel Chatterjee Joel M Montgomery Mike Flint C ésar Albariño Christina F Spiropoulou Source Type: research
Neglected tropical diseases risk correlates with poverty and early ecosystem destruction
ConclusionsDestruction of natural ecosystems coupled with low income explain macro-scale neglected tropical and zoonotic disease probability in Brazil. Addition of socioeconomic variables improves transmission risk forecasts on tandem with environmental variables. Our results highlight that to efficiently address neglected tropical diseases, public health strategies must target both reduction of poverty and cessation of destruction of natural forests and savannas. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 10, 2023 Category: Infectious Diseases Source Type: research
Viruses, Vol. 15, Pages 921: The Power of We
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“The Power of We” is a personal tribute to the individuals and organizations that collaborated in the discovery and advancement of knowledge of the hantaviruses following the original isolation of Hantaan virus by Ho Wang Lee. It focuses on the work done primarily at the United States Army Medical Research Institute of Infectious Diseases during the decade of the 1980s under the leadership of Joel Dalrymple, who worked in close partnership with Ho Wang Lee. These early studies helped define the global distribution of Seoul virus and provided seminal information on its maintenance and trans...
Source: Viruses - April 5, 2023 Category: Virology Authors: James W. Le Duc Tags: Opinion Source Type: research
Viruses, Vol. 15, Pages 881: Phylogeny of Shrew- and Mole-Borne Hantaviruses in Poland and Ukraine
erski
Richard Yanagihara
Earlier, we demonstrated the co-circulation of genetically distinct non-rodent-borne hantaviruses, including Boginia virus (BOGV) in the Eurasian water shrew (Neomys fodiens), Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus) and Nova virus (NVAV) in the European mole (Talpa europaea), in central Poland. To further investigate the phylogeny of hantaviruses harbored by soricid and talpid reservoir hosts, we analyzed RNAlater®-preserved lung tissues from 320 shrews and 26 moles, both captured during 1990–2017 across Poland, and 10 European moles from Ukr...
Source: Viruses - March 29, 2023 Category: Virology Authors: Fuka Kikuchi Satoru Arai Janusz Hejduk Ai Hayashi Janusz Markowski Marcin Markowski Leszek Rychlik Vasyl Khodzinskyi Hajime Kamiya Tetsuya Mizutani Motoi Suzuki Beata Sikorska Pawe ł P. Liberski Richard Yanagihara Tags: Article Source Type: research
Viruses, Vol. 15, Pages 872: Hantavirus Infection in Children & mdash;A Pilot Study of Single Regional Center
Conclusions: HFRS should always be considered as a differential diagnosis when faced with a patient with AKI and thrombocytopenia. Dobrava serotype is the most common hantavirus subtype in the Balkans. For the specific prevention of human infections, mainly in high-risk groups, vaccines are needed. As far as we know, this is the first study on HFRS in Romanian children. (Source: Viruses)
Source: Viruses - March 29, 2023 Category: Virology Authors: Adriana Mocanu Ana-Maria Cajvan Tudor Ilie Lazaruc Vasile Valeriu Lupu Laura Florescu Ancuta Lupu Roxana Alexandra Bogos Ileana Ioniuc Georgiana Scurtu Felicia Dragan Iuliana Magdalena Starcea Tags: Article Source Type: research
Risk of lymphoid malignancies increased after Puumala virus infection in Finland, 2009-2019: a retrospective register-based cohort study
CONCLUSIONS: PUUV infection is associated with lymphoid malignancies in the Finnish population, supporting the earlier studies. Further research is required to understand the pathophysiological mechanisms behind this association.PMID:36948450 | DOI:10.1016/j.ijid.2023.03.026 (Source: Cancer Control)
Source: Cancer Control - March 22, 2023 Category: Cancer & Oncology Authors: Sohvi K ääriäinen Jukka Ollgren Timothee Dub Outi Laine Marjatta Sinisalo Jussi Hepojoki Tomas Strandin Eliisa Kek äläinen Jussi Sane Outi Lyytik äinen Source Type: research
Viruses, Vol. 15, Pages 805: Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome
i
Jukka Mustonen
The clinical outcome of Puumala hantavirus (PUUV) infection shows extensive variation, ranging from inapparent subclinical infection (70–80%) to severe hemorrhagic fever with renal syndrome (HFRS), with about 0.1% of cases being fatal. Most hospitalized patients experience acute kidney injury (AKI), histologically known as acute hemorrhagic tubulointerstitial nephritis. Why this variation? There is no evidence that there would be more virulent and less virulent variants infecting humans, although this has not been extensively studied. Individuals with the human leukocyte antigen (HLA) a...
Source: Viruses - March 22, 2023 Category: Virology Authors: Antti Vaheri Teemu Smura Hanna Vauhkonen Jussi Hepojoki Tarja Sironen Tomas Strandin Johanna Tiet äväinen Tuula Outinen Satu M äkelä Ilkka P örsti Jukka Mustonen Tags: Opinion Source Type: research
Risk of lymphoid malignancies increased after Puumala virus infection in Finland, 2009-2019: a retrospective register-based cohort study
Puumala virus (PUUV) is a hantavirus causing haemorrhagic fever with renal syndrome. Studies showing an increased risk of lymphoid malignancies following hantavirus infection, together with the observation that PUUV infects B cells motivated us to study the risk of lymphoid malignancies following PUUV infection. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 20, 2023 Category: Infectious Diseases Authors: Sohvi K ääriäinen, Jukka Ollgren, Timothee Dub, Outi Laine, Marjatta Sinisalo, Jussi Hepojoki, Tomas Strandin, Eliisa Kekäläinen, Jussi Sane, Outi Lyytikäinen Source Type: research
Pseudotyped Viruses for Orthohantavirus
Adv Exp Med Biol. 2023;1407:229-252. doi: 10.1007/978-981-99-0113-5_12.ABSTRACTOrthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense, single-stranded, tripartite RNA viruses. They are emerging zoonotic pathogens carried by small mammals including rodents, moles, shrews, and bats and are the etiologic agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) among humans. With the characteristics of low biological risk but strong operability, a variety of pseudotyped viruses have been constructed as ...
Source: Advances in Experimental Medicine and Biology - March 15, 2023 Category: Research Authors: Tingting Ning Weijin Huang Li Min Yi Yang Si Liu Junxuan Xu Nan Zhang Si-An Xie Shengtao Zhu Youchun Wang Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: The American Journal of Tropical Medicine and Hygiene - March 13, 2023 Category: Tropical Medicine Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: The American Journal of Tropical Medicine and Hygiene - March 13, 2023 Category: Tropical Medicine Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
