Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: The American Journal of Tropical Medicine and Hygiene - March 13, 2023 Category: Tropical Medicine Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: The American Journal of Tropical Medicine and Hygiene - March 13, 2023 Category: Tropical Medicine Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: The American Journal of Tropical Medicine and Hygiene - March 13, 2023 Category: Tropical Medicine Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: The American Journal of Tropical Medicine and Hygiene - March 13, 2023 Category: Tropical Medicine Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana
We describe the clinical parameters and management of nine confirmed cases of hantavirus pulmonary syndrome reported in French Guiana since 2008. All patients were admitted to Cayenne Hospital. Seven patients were men and the mean age was 48 years (range, 19-71 years). Two phases characterized the disease. The prodromal phase was characterized by fever (77.8%), myalgia (66.7%), and gastrointestinal symptoms (vomiting and diarrhea; 55.6%) starting, on average, 5 days before the illness phase, which was characterized by respiratory failure in all patients. Five patients died (55.6%) and the length of stay in the intensive ca...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: S éverine Matheus St éphanie Houcke Guy Roger Lontsi Ngoula Pablo Lecaros Jean Marc Pujo Nicolas Higel Absetou Ba Fabrice Cook Patrick Djahi Dabor Resiere Didier Hommel Anne Lavergne Hatem Kallel Source Type: research
Viruses, Vol. 15, Pages 695: Potentially Zoonotic Viruses in Wild Rodents, United Arab Emirates, 2019 & mdash;A Pilot Study
In conclusion, we could not find evidence of persistence or shedding of potentially zoonotic viruses in the investigated rodent cohorts of limited sample size. (Source: Viruses)
Source: Viruses - March 7, 2023 Category: Virology Authors: Pia Weidinger Jolanta Kolodziejek Tamer Khafaga Tom Loney Brigitte Howarth Moayyed Sher Shah Ahmad Abou Tayoun Alawi Alsheikh-Ali Jeremy V. Camp Norbert Nowotny Tags: Article Source Type: research
Viruses, Vol. 15, Pages 612: Tropism of Puumala orthohantavirus and Endoparasite Coinfection in the Bank Vole Reservoir
iane Herden
In Europe, most cases of human hantavirus disease are caused by Puumala orthohantavirus (PUUV) transmitted by bank voles (Clethrionomys glareolus, syn. Myodes glareolus), in which PUUV causes inconspicuous infection. Little is known about tropism and endoparasite coinfections in PUUV-infected reservoir and spillover-infected rodents. Here, we characterized PUUV tropism, pathological changes and endoparasite coinfections. The voles and some non-reservoir rodents were examined histologically, immunohistochemically, by in situ hybridization, indirect IgG enzyme-linked immunosorbent assay and reverse transcript...
Source: Viruses - February 23, 2023 Category: Virology Authors: Elfi K. Schlohsarczyk Stephan Drewes Pawe ł Koteja Susanne R öhrs Rainer G. Ulrich Jens P. Teifke Christiane Herden Tags: Article Source Type: research
Viruses, Vol. 15, Pages 532: Characterization of a Panel of Cross-Reactive Hantavirus Nucleocapsid Protein-Specific Monoclonal Antibodies
Rainer G. Ulrich
Hantaviruses are emerging pathogens with a worldwide distribution that can cause life-threatening diseases in humans. Monoclonal antibodies (MAbs) against hantavirus nucleocapsid (N) proteins are important tools in virus diagnostics, epidemiological studies and basic research studies on virus replication and pathogenesis. Here, we extend the collection of previously generated MAbs raised against a segment of Puumala orthohantavirus (PUUV) N protein harbored on virus-like particles (VLPs) and MAbs against N proteins of Sin Nombre orthohantavirus/Andes orthohantavirus by generating nine novel MAbs agains...
Source: Viruses - February 14, 2023 Category: Virology Authors: Aliona Avi žinienė Indr ė Kučinskaitė-Kodzė Rasa Petraityt ė-Burneikienė Aurelija Žvirblienė Marc L. Mertens Sabrina Schmidt Mathias Schlegel Erik Lattwein Bernd Koellner Rainer G. Ulrich Tags: Article Source Type: research
Identification of novel inhibitors against hantaviruses through 2D fingerprinting and molecular modeling approaches
In this study, an envelope glycoprotein, Gn, was targeted. The glycoproteins, which are the sole targets of neutralizing antibodies, drive virus entry via receptor-mediated endocytosis and endosomal membrane fusion. Inhibitors are herein proposed to negate its action mechanism. On the basis of the scaffolds of favipiravir, a FDA compound already used against hantavirus, a library was designed using a 2D fingerprinting approach. Upon molecular docking analysis, the top four docked compounds—(1) favipiravir (-4.5 kcal/mol), (2) N-hydroxy-3-oxo-3, 4-dihydropyrazine-2-carboxamide (-4.7 kcal/mol), (3) N, 5, 6-trimethyl-2-oxo-...
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
Hantavirus infection as a risk factor for chronic kidney disease of unknown aetiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis
Conclusion. Hantavirus infection has been prevalent in two distant CKDu-endemic areas since 2010. The observed significant association of hantavirus seropositivity with CKDu indicates a possible role of hantavirus infection in CKDu pathogenesis.PMID:36748416 | DOI:10.1099/jmm.0.001630 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: Chandika D Gamage Shanika Nanayakkara Yomani D Sarathkumara Devinda S Muthusinghe Kenta Shimizu Jiro Arikawa Sithumini M W Lokupathirage Nishantha Nanayakkara Lishanthe Gunarathne Rohana Chandrajith Kouji H Harada Akio Koizumi Kumiko Yoshimatsu Source Type: research
Hantavirus infection as a risk factor for chronic kidney disease of unknown aetiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis
Conclusion. Hantavirus infection has been prevalent in two distant CKDu-endemic areas since 2010. The observed significant association of hantavirus seropositivity with CKDu indicates a possible role of hantavirus infection in CKDu pathogenesis.PMID:36748416 | DOI:10.1099/jmm.0.001630 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: Chandika D Gamage Shanika Nanayakkara Yomani D Sarathkumara Devinda S Muthusinghe Kenta Shimizu Jiro Arikawa Sithumini M W Lokupathirage Nishantha Nanayakkara Lishanthe Gunarathne Rohana Chandrajith Kouji H Harada Akio Koizumi Kumiko Yoshimatsu Source Type: research
GSE202182 A specific molecular signature in SARS-CoV-2 infected kidney biopsies
Contributors : Paul Vergnaud ; Matthieu Jamme ; Serge Garbay ; Alexandre Karras ; Dany Anglicheau ; Val érie Galantine ; Arwa J Eddine ; Clément Gosset ; Frank Pourcine ; Mohammed Zarhrate ; Jean-Baptiste Gibier ; Marco Pontoglio ; Fabiola Terzi ; Marion RabantSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize the pathophysiology of kidney injury in a large kidney biopsy series of living SARS-CoV-2 –infected patientsRNA-seq was performed to compare transcriptional changes in damaged kidneys of COVID-19 patients to those of healthy, non-COVID-19 injured ki...
Source: GEO: Gene Expression Omnibus - February 7, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
