Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor
In this study, we discovered that benidipine hydrochloride, a calcium channel blocker, inhibits the entry of hantaviruses in vitro. Moreover, an array of calcium channel inhibitors, such as cilnidipine, felodipine, amlodipine, manidipine, nicardipine, and nisoldipine, exhibit similar antiviral properties. Using pseudotyped vesicular stomatitis viruses harboring the different hantavirus glycoproteins, we demonstrate that benidipine hydrochloride inhibits the infection by both HFRS- and HPS-causing hantaviruses. The results of our study indicate the possibility of repurposing FDA-approved calcium channel blockers for the tre...
Source: Frontiers in Pharmacology - August 29, 2022 Category: Drugs & Pharmacology Source Type: research
Viruses, Vol. 14, Pages 1516: Monitoring Urban Zoonotic Virus Activity: Are City Rats a Promising Surveillance Tool for Emerging Viruses?
Walzer
Urban environments represent unique ecosystems where dense human populations may come into contact with wildlife species, some of which are established or potential reservoirs for zoonotic pathogens that cause human diseases. Finding practical ways to monitor the presence and/or abundance of zoonotic pathogens is important to estimate the risk of spillover to humans in cities. As brown rats (Rattus norvegicus) are ubiquitous in urban habitats, and are hosts of several zoonotic viruses, we conducted longitudinal sampling of brown rats in Vienna, Austria, a large population center in Central Europe. We investigate...
Source: Viruses - July 11, 2022 Category: Virology Authors: Jeremy V. Camp Am élie Desvars-Larrive Norbert Nowotny Chris Walzer Tags: Article Source Type: research
Exotic viral hepatitis; a review on epidemiology, pathogenesis, and treatment
Certain “exotic” viruses are known to cause clinical diseases with potential liver involvement. These include viruses, outside the scope of regular hepatotropic viruses (hepatitis A, -B(D), -C, -E, CMV, EBV), that can be found in (sub)tropical areas causing “exotic viral hepatitis”. Transmission rou tes are mostly arthropod born (Crimean Congo haemorrhagic fever, dengue, Rift Valley fever, yellow fever). However, others are transmitted by the aerosolised excreta of rodents (Hantavirus, Lassa fever), or via direct contact or contact with bodily fluids (Ebola). (Source: Journal of Hepatology)
Source: Journal of Hepatology - July 8, 2022 Category: Gastroenterology Authors: Leanne P.M. van Leeuwen, Wesley de Jong, Laura Doornekamp, Eric C.M. van Gorp, Pieter.J. Wismans, Marco Goeijenbier Tags: Review Source Type: research
Exotic viral hepatitis: A review on epidemiology, pathogenesis, and treatment
Certain “exotic” viruses are known to cause clinical diseases with potential liver involvement. These include viruses, beyond regular hepatotropic viruses (hepatitis A, -B(D), -C, -E, cytomegalovirus, Epstein-Barr virus), that can be found in (sub)tropical areas and can cause “exotic viral hepatitis” . Transmission routes typically involve arthropods (Crimean Congo haemorrhagic fever, dengue, Rift Valley fever, yellow fever). However, some of these viruses are transmitted by the aerosolised excreta of rodents (Hantavirus, Lassa fever), or via direct contact or contact with bodily fluids (Ebola). (Source: Journal of Hepatology)
Source: Journal of Hepatology - July 8, 2022 Category: Gastroenterology Authors: Leanne P.M. van Leeuwen, Wesley de Jong, Laura Doornekamp, Eric C.M. van Gorp, Pieter.J. Wismans, Marco Goeijenbier Tags: Review Source Type: research
Mapping the viruses belonging to the order Bunyavirales in China
ConclusionsA variety ofBunyavirales viruses are widely distributed in China, and the two major neglectedBunyavirales viruses including CCHFV and RVFV, both have the potential for outbreaks in local areas of China. Our study can help to promote the understanding of risk distribution and disease burden ofBunyavirales viruses in China, and the risk maps of CCHFV and RVFV occurrence are crucial to the targeted surveillance and control, especially in seasons and locations at high risk.Graphical abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 7, 2022 Category: Infectious Diseases Source Type: research
In vitro Anti-Hantavirus Activity of Protein Kinase Inhibitor 8G1 Targeting AKT/mTOR/eIF4E Signaling Pathway
Hantaan virus (HTNV) is the main cause of hemorrhagic fever with renal syndrome (HFRS) around the world, which results in profound morbidity and mortality. However, there are currently no FDA-approved therapeutics or vaccines against HFRS. To find new anti-HTNV drugs, the inhibitory activity of 901 small molecule kinase inhibitors against HTNV is analyzed. Among these compounds, compound 8G1 inhibits HTNV with a relatively high inhibition rate and lower toxicity. The viral titer and nucleocapsid protein of HTNV are reduced after compound 8G1 treatment in a dose-dependent manner at concentrations ranging from 1 to 20 μM. I...
Source: Frontiers in Microbiology - June 30, 2022 Category: Microbiology Source Type: research
Design and validation of a questionnaire to measure hantavirus preventive practices in an endemic community
CONCLUSIONS.: The Hantavirus preventive practical questionnaire is a brief instrument that shows acceptable psychometric properties to measure the activities or behaviors that people carry out to prevent hantavirus.PMID:35766739 | DOI:10.17843/rpmesp.2022.391.9740 (Source: Revista Peruana de Medicina de Experimental y Salud Publica)
Source: Revista Peruana de Medicina de Experimental y Salud Publica - June 29, 2022 Category: International Medicine & Public Health Authors: Janeth Agrazal-Garc ía Lydia Gordon-de Isaacs Ricaurte Tu ñón Source Type: research
