Viruses, Vol. 15, Pages 1798: Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay
B. Jonsson
Several hantaviruses result in zoonotic infections of significant public health concern, causing hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS) in the Old and New World, respectively. Given a 35% case fatality rate, disease-causing New World hantaviruses require a greater understanding of their biology, genetic diversity, and geographical distribution. Juquitiba hantaviruses have been identified in Oligoryzomys nigripes in Brazil, Paraguay, and Uruguay. Brazil has reported the most HCPS cases associated with this virus. We used a multiplexed, amplicon-based PCR st...
Source: Viruses - August 24, 2023 Category: Virology Authors: Evans Ifebuche Nnamani Briana Spruill-Harrell Evan Peter Williams Mariah K. Taylor Robert D. Owen Colleen B. Jonsson Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1806: Modeling the Immune Response for Pathogenic and Nonpathogenic Orthohantavirus Infections in Human Lung Microvasculature Endothelial Cells
In conclusion, we show that there was no difference in the transcriptional profiles of key genes in primary HLMVECs following infection by pathogenic and nonpathogenic hantaviruses, with protein secretion levels being more donor-specific than virus-specific. (Source: Viruses)
Source: Viruses - August 24, 2023 Category: Virology Authors: Evan P. Williams Aadrita Nandi Victoria Nam Linda J. S. Allen A. Alexandre Trindade Michele M. Kosiewicz Colleen B. Jonsson Tags: Article Source Type: research
Potential clinical biomarkers in monitoring the severity of Hantaan virus infection
Cytokine. 2023 Aug 20;170:156340. doi: 10.1016/j.cyto.2023.156340. Online ahead of print.ABSTRACTHantavirus, which causes hemorrhagic fever with renal syndrome (HFRS) is almost prevalent worldwide. While Hantaan virus (HTNV) causes the most severe form of HFRS with typical clinical manifestations of thrombocytopenia, increased vascular permeability, and acute kidney injury. Although the knowledge of the pathogenesis of HFRS is still limited, immune dysfunction and pathological damage caused by disorders of immune regulation are proposed to play a vital role in the development of the disorder, and the endothelium is conside...
Source: Cytokine - August 22, 2023 Category: Molecular Biology Authors: Han-Dong Zhao Ju-Jun Sun Hong-Li Liu Source Type: research
Potential clinical biomarkers in monitoring the severity of Hantaan virus infection
Cytokine. 2023 Aug 20;170:156340. doi: 10.1016/j.cyto.2023.156340. Online ahead of print.ABSTRACTHantavirus, which causes hemorrhagic fever with renal syndrome (HFRS) is almost prevalent worldwide. While Hantaan virus (HTNV) causes the most severe form of HFRS with typical clinical manifestations of thrombocytopenia, increased vascular permeability, and acute kidney injury. Although the knowledge of the pathogenesis of HFRS is still limited, immune dysfunction and pathological damage caused by disorders of immune regulation are proposed to play a vital role in the development of the disorder, and the endothelium is conside...
Source: Cytokine - August 22, 2023 Category: Molecular Biology Authors: Han-Dong Zhao Ju-Jun Sun Hong-Li Liu Source Type: research
Potential clinical biomarkers in monitoring the severity of Hantaan virus infection
Cytokine. 2023 Aug 20;170:156340. doi: 10.1016/j.cyto.2023.156340. Online ahead of print.ABSTRACTHantavirus, which causes hemorrhagic fever with renal syndrome (HFRS) is almost prevalent worldwide. While Hantaan virus (HTNV) causes the most severe form of HFRS with typical clinical manifestations of thrombocytopenia, increased vascular permeability, and acute kidney injury. Although the knowledge of the pathogenesis of HFRS is still limited, immune dysfunction and pathological damage caused by disorders of immune regulation are proposed to play a vital role in the development of the disorder, and the endothelium is conside...
Source: Cytokine - August 22, 2023 Category: Molecular Biology Authors: Han-Dong Zhao Ju-Jun Sun Hong-Li Liu Source Type: research
Hantavirus infections in the South ‑Eastern European countries: A study of two cases and literature review
Exp Ther Med. 2023 Jul 21;26(3):430. doi: 10.3892/etm.2023.12129. eCollection 2023 Sep.ABSTRACTHantavirus infection is a rare zoonosis in South-Eastern Europe. Depending on the serotype involved, the virus can cause hemorrhagic fever with renal syndrome which is also known as endemic nephropathy, and cardiopulmonary syndrome. Prompt diagnosis of the disease is essential for reducing the risk of severe manifestations and complications like chronic kidney disease, secondary hypertension or even death because there is no specific treatment or vaccine approved. The present study reported two cases of hemorrhagic fever with ren...
Source: Experimental and Therapeutic Medicine - August 21, 2023 Category: General Medicine Authors: Gabriela Lupu şoru Andreea Gabriella Andronesi Mircea Lupu şoru Ioana Ailinc ăi Ruxandra Sfeatcu Ileana V ăcăroiu Mihaela Banu Camelia Achim Gener Ismail Source Type: research
Viruses, Vol. 15, Pages 1705: Zoonotic Hantaviridae with Global Public Health Significance
Shao
Ming Liao
Hantaviridae currently encompasses seven genera and 53 species. Multiple hantaviruses such as Hantaan virus, Seoul virus, Dobrava-Belgrade virus, Puumala virus, Andes virus, and Sin Nombre virus are highly pathogenic to humans. They cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome or hantavirus pulmonary syndrome (HCPS/HPS) in many countries. Some hantaviruses infect wild or domestic animals without causing severe symptoms. Rodents, shrews, and bats are reservoirs of various mammalian hantaviruses. Recent years have witnessed significant advancements in the st...
Source: Viruses - August 8, 2023 Category: Virology Authors: Rui-Xu Chen Huan-Yu Gong Xiu Wang Ming-Hui Sun Yu-Fei Ji Su-Mei Tan Ji-Ming Chen Jian-Wei Shao Ming Liao Tags: Review Source Type: research
Cerebral Vasomotor Reactivity in COVID-19: A Narrative Review
Life (Basel). 2023 Jul 24;13(7):1614. doi: 10.3390/life13071614.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Among COVID-19 patients, the endothelium is considered the Achilles heel. A variety of endothelial dysfunctions may result from SARS-CoV-2 infection and subsequent endotheliitis, such as altered vascular tone, oxidative stress, and cytokine storms. The cerebral hemodynamic impairment that is caused is associated with a higher probability of severe disease and poor outcomes in patients with COVID-19. This...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Zahra Ghotbi Mehrdad Estakhr Melika Hosseini Reza Bavarsad Shahripour Source Type: research
Cerebral Vasomotor Reactivity in COVID-19: A Narrative Review
Life (Basel). 2023 Jul 24;13(7):1614. doi: 10.3390/life13071614.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Among COVID-19 patients, the endothelium is considered the Achilles heel. A variety of endothelial dysfunctions may result from SARS-CoV-2 infection and subsequent endotheliitis, such as altered vascular tone, oxidative stress, and cytokine storms. The cerebral hemodynamic impairment that is caused is associated with a higher probability of severe disease and poor outcomes in patients with COVID-19. This...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Zahra Ghotbi Mehrdad Estakhr Melika Hosseini Reza Bavarsad Shahripour Source Type: research
Navigating paediatric virology through the COVID ‑19 era (Review)
Int J Mol Med. 2023 Sep;52(3):83. doi: 10.3892/ijmm.2023.5286. Epub 2023 Jul 28.ABSTRACTThe present review article presents the key messages of the 8th Workshop on Paediatric Virology organised virtually by the Institute of Paediatric Virology based on the island of Euboea in Greece. The major topics covered during the workshop were the following: i) New advances in antiviral agents and vaccines against cytomegalovirus; ii) hantavirus nephropathy in children; iii) human rhinovirus infections in children requiring paediatric intensive care; iv) complications and management of human adenovirus infections; v) challenges of po...
Source: International Journal of Molecular Medicine - July 28, 2023 Category: Molecular Biology Authors: Ioannis N Mammas Simon B Drysdale Charalampos Charalampous Patra Koletsi Alexia Papatheodoropoulou Chryssie Koutsaftiki Theodoros Sergentanis Kyriakoula Merakou Helen Kornarou Georgia Papaioannou Anna Kramvis Anne Greenough Maria Theodoridou Demetrios A S Source Type: research
Navigating paediatric virology through the COVID ‑19 era (Review)
Int J Mol Med. 2023 Sep;52(3):83. doi: 10.3892/ijmm.2023.5286. Epub 2023 Jul 28.ABSTRACTThe present review article presents the key messages of the 8th Workshop on Paediatric Virology organised virtually by the Institute of Paediatric Virology based on the island of Euboea in Greece. The major topics covered during the workshop were the following: i) New advances in antiviral agents and vaccines against cytomegalovirus; ii) hantavirus nephropathy in children; iii) human rhinovirus infections in children requiring paediatric intensive care; iv) complications and management of human adenovirus infections; v) challenges of po...
Source: Molecular Medicine - July 28, 2023 Category: Molecular Biology Authors: Ioannis N Mammas Simon B Drysdale Charalampos Charalampous Patra Koletsi Alexia Papatheodoropoulou Chryssie Koutsaftiki Theodoros Sergentanis Kyriakoula Merakou Helen Kornarou Georgia Papaioannou Anna Kramvis Anne Greenough Maria Theodoridou Demetrios A S Source Type: research
Navigating paediatric virology through the COVID ‑19 era (Review)
Int J Mol Med. 2023 Sep;52(3):83. doi: 10.3892/ijmm.2023.5286. Epub 2023 Jul 28.ABSTRACTThe present review article presents the key messages of the 8th Workshop on Paediatric Virology organised virtually by the Institute of Paediatric Virology based on the island of Euboea in Greece. The major topics covered during the workshop were the following: i) New advances in antiviral agents and vaccines against cytomegalovirus; ii) hantavirus nephropathy in children; iii) human rhinovirus infections in children requiring paediatric intensive care; iv) complications and management of human adenovirus infections; v) challenges of po...
Source: International Journal of Molecular Medicine - July 28, 2023 Category: Molecular Biology Authors: Ioannis N Mammas Simon B Drysdale Charalampos Charalampous Patra Koletsi Alexia Papatheodoropoulou Chryssie Koutsaftiki Theodoros Sergentanis Kyriakoula Merakou Helen Kornarou Georgia Papaioannou Anna Kramvis Anne Greenough Maria Theodoridou Demetrios A S Source Type: research
Navigating paediatric virology through the COVID ‑19 era (Review)
Int J Mol Med. 2023 Sep;52(3):83. doi: 10.3892/ijmm.2023.5286. Epub 2023 Jul 28.ABSTRACTThe present review article presents the key messages of the 8th Workshop on Paediatric Virology organised virtually by the Institute of Paediatric Virology based on the island of Euboea in Greece. The major topics covered during the workshop were the following: i) New advances in antiviral agents and vaccines against cytomegalovirus; ii) hantavirus nephropathy in children; iii) human rhinovirus infections in children requiring paediatric intensive care; iv) complications and management of human adenovirus infections; v) challenges of po...
Source: Molecular Medicine - July 28, 2023 Category: Molecular Biology Authors: Ioannis N Mammas Simon B Drysdale Charalampos Charalampous Patra Koletsi Alexia Papatheodoropoulou Chryssie Koutsaftiki Theodoros Sergentanis Kyriakoula Merakou Helen Kornarou Georgia Papaioannou Anna Kramvis Anne Greenough Maria Theodoridou Demetrios A S Source Type: research
