A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles
Mini Rev Med Chem. 2023 Nov 24. doi: 10.2174/0113895575277122231108095511. Online ahead of print.ABSTRACTOut of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ra...
Source: Mini Reviews in Medicinal Chemistry - November 27, 2023 Category: Chemistry Authors: Thoraya A Farghaly Ghada S Masaret Sayed M Riyadh Marwa F Harras Source Type: research
A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles
Mini Rev Med Chem. 2023 Nov 24. doi: 10.2174/0113895575277122231108095511. Online ahead of print.ABSTRACTOut of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ra...
Source: Herpes - November 27, 2023 Category: Infectious Diseases Authors: Thoraya A Farghaly Ghada S Masaret Sayed M Riyadh Marwa F Harras Source Type: research
A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles
Mini Rev Med Chem. 2023 Nov 24. doi: 10.2174/0113895575277122231108095511. Online ahead of print.ABSTRACTOut of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ra...
Source: Mini Reviews in Medicinal Chemistry - November 27, 2023 Category: Chemistry Authors: Thoraya A Farghaly Ghada S Masaret Sayed M Riyadh Marwa F Harras Source Type: research
A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles
Mini Rev Med Chem. 2023 Nov 24. doi: 10.2174/0113895575277122231108095511. Online ahead of print.ABSTRACTOut of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ra...
Source: Mini Reviews in Medicinal Chemistry - November 27, 2023 Category: Chemistry Authors: Thoraya A Farghaly Ghada S Masaret Sayed M Riyadh Marwa F Harras Source Type: research
A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles
Mini Rev Med Chem. 2023 Nov 24. doi: 10.2174/0113895575277122231108095511. Online ahead of print.ABSTRACTOut of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ra...
Source: Mini Reviews in Medicinal Chemistry - November 27, 2023 Category: Chemistry Authors: Thoraya A Farghaly Ghada S Masaret Sayed M Riyadh Marwa F Harras Source Type: research
Direct and indirect effects of Puumala hantavirus on platelet function
Thromb Res. 2023 Nov 20;233:41-54. doi: 10.1016/j.thromres.2023.11.017. Online ahead of print.ABSTRACTThrombocytopenia is a cardinal symptom of hantavirus-induced diseases including Puumala virus (PUUV)-induced hemorrhagic fever with renal syndrome (HFRS), which is associated with impaired platelet function, bleeding manifestations and augmented thrombotic risk. However, the underlying mechanisms causing thrombocytopenia and platelet hypo-responsiveness are unknown. Thus, we investigated the direct and indirect impact of PUUV on platelet production, function and degradation. Analysis of PUUV-HFRS patient blood revealed tha...
Source: Cell Research - November 25, 2023 Category: Cytology Authors: Waltraud C Schrottmaier Anna Schmuckenschlager Therese Thunberg Julia Wigren-Bystr öm Anne-Marie Fors-Connolly Alice Assinger Clas Ahlm Mattias N E Forsell Source Type: research
Direct and indirect effects of Puumala hantavirus on platelet function
Thrombocytopenia is a cardinal symptom of hantavirus-induced diseases including Puumala virus (PUUV)-induced hemorrhagic fever with renal syndrome (HFRS), which is associated with impaired platelet function, bleeding manifestations and augmented thrombotic risk. However, the underlying mechanisms causing thrombocytopenia and platelet hypo-responsiveness are unknown. Thus, we investigated the direct and indirect impact of PUUV on platelet production, function and degradation.Analysis of PUUV-HFRS patient blood revealed that platelet hypo-responsiveness in PUUV infection was cell-intrinsic and accompanied by reduced platelet...
Source: Thrombosis Research - November 19, 2023 Category: Hematology Authors: Waltraud C. Schrottmaier, Anna Schmuckenschlager, Therese Thunberg, Julia Wigren Bystr öm, Anne-Marie Fors-Connolly, Alice Assinger, Clas Ahlm, Mattias N.E. Forsell Tags: Full Length Article Source Type: research
Viruses, Vol. 15, Pages 2266: Presence and Persistence of Andes Virus RNA in Human Semen
In this study, we present the follow-up of a male patient who recovered from HCPS six years ago. We demonstrate that the ANDV genome persists within the reproductive tract for at least 71 months. Genome sequence analysis early and late after infection reveals a low number of mutations (two single nucleotide variants and one deletion), suggesting limited replication activity. We can exclude the integration of the viral genome into the host genome, since the treatment of the specimen with RNAse led to a loss of signal. We demonstrate a long-lasting, strong neutralizing antibody response using pseudovirions expressing the AND...
Source: Viruses - November 17, 2023 Category: Virology Authors: Roland Z üst Rahel Ackermann-G äumann Nicole Liechti Denise Siegrist Sarah Ryter Jasmine Portmann Nicole Lenz Christian Beuret Roger Koller Cornelia Staehelin Andrea B. Kuenzli Jonas Marschall Sylvia Rothenberger Olivier Engler Tags: Article Source Type: research
Genetic variants associated with hantavirus infection in a reservoir host are related to regulation of inflammation and immune surveillance
Infect Genet Evol. 2023 Nov 11:105525. doi: 10.1016/j.meegid.2023.105525. Online ahead of print.ABSTRACTThe immunogenetics of wildlife populations influence the epidemiology and evolutionary dynamic of the host-pathogen system. Profiling immune gene diversity present in wildlife may be especially important for those species that, while not at risk of disease or extinction themselves, are host to diseases that are a threat to humans, other wildlife, or livestock. Hantaviruses (genus: Orthohantavirus) are globally distributed zoonotic RNA viruses with pathogenic strains carried by a diverse group of rodent hosts. The marsh r...
Source: Infection, Genetics and Evolution - November 13, 2023 Category: Genetics & Stem Cells Authors: Anna A P érez-Umphrey Amie E Settlecowski Jean P Elbers S Tyler Williams Colleen B Jonsson Andrea Bonisoli-Alquati Allison M Snider Sabrina S Taylor Source Type: research
Genetic variants associated with hantavirus infection in a reservoir host are related to regulation of inflammation and immune surveillance
Infect Genet Evol. 2023 Nov 11:105525. doi: 10.1016/j.meegid.2023.105525. Online ahead of print.ABSTRACTThe immunogenetics of wildlife populations influence the epidemiology and evolutionary dynamic of the host-pathogen system. Profiling immune gene diversity present in wildlife may be especially important for those species that, while not at risk of disease or extinction themselves, are host to diseases that are a threat to humans, other wildlife, or livestock. Hantaviruses (genus: Orthohantavirus) are globally distributed zoonotic RNA viruses with pathogenic strains carried by a diverse group of rodent hosts. The marsh r...
Source: Infection, Genetics and Evolution - November 13, 2023 Category: Genetics & Stem Cells Authors: Anna A P érez-Umphrey Amie E Settlecowski Jean P Elbers S Tyler Williams Colleen B Jonsson Andrea Bonisoli-Alquati Allison M Snider Sabrina S Taylor Source Type: research
Genetic variants associated with hantavirus infection in a reservoir host are related to regulation of inflammation and immune surveillance
Infect Genet Evol. 2023 Nov 11:105525. doi: 10.1016/j.meegid.2023.105525. Online ahead of print.ABSTRACTThe immunogenetics of wildlife populations influence the epidemiology and evolutionary dynamic of the host-pathogen system. Profiling immune gene diversity present in wildlife may be especially important for those species that, while not at risk of disease or extinction themselves, are host to diseases that are a threat to humans, other wildlife, or livestock. Hantaviruses (genus: Orthohantavirus) are globally distributed zoonotic RNA viruses with pathogenic strains carried by a diverse group of rodent hosts. The marsh r...
Source: Infection, Genetics and Evolution - November 13, 2023 Category: Genetics & Stem Cells Authors: Anna A P érez-Umphrey Amie E Settlecowski Jean P Elbers S Tyler Williams Colleen B Jonsson Andrea Bonisoli-Alquati Allison M Snider Sabrina S Taylor Source Type: research
Genetic variants associated with hantavirus infection in a reservoir host are related to regulation of inflammation and immune surveillance
Infect Genet Evol. 2023 Nov 11:105525. doi: 10.1016/j.meegid.2023.105525. Online ahead of print.ABSTRACTThe immunogenetics of wildlife populations influence the epidemiology and evolutionary dynamic of the host-pathogen system. Profiling immune gene diversity present in wildlife may be especially important for those species that, while not at risk of disease or extinction themselves, are host to diseases that are a threat to humans, other wildlife, or livestock. Hantaviruses (genus: Orthohantavirus) are globally distributed zoonotic RNA viruses with pathogenic strains carried by a diverse group of rodent hosts. The marsh r...
Source: Infection, Genetics and Evolution - November 13, 2023 Category: Genetics & Stem Cells Authors: Anna A P érez-Umphrey Amie E Settlecowski Jean P Elbers S Tyler Williams Colleen B Jonsson Andrea Bonisoli-Alquati Allison M Snider Sabrina S Taylor Source Type: research
Pathogenicity of novel hantavirus isolate and antigenicity and immunogenicity of novel strain-based inactivated vaccine
CONCLUSIONS: These findings suggest that the inactivated HTNV vaccine may stimulate mice to produce high levels of antibodies with neutralization activity and elicit specific anti-HTNV humoral and cellular immune responses in BALB/c mice against the prevalent strain of HTNV in south central China.PMID:37953099 | DOI:10.1016/j.vaccine.2023.11.017 (Source: Vaccine)
Source: Vaccine - November 12, 2023 Category: Allergy & Immunology Authors: Yuan-Yuan Liu Ying-Qi Xu Yan Zhong Fei Wei Jia-Xin Ling Jin-Lin Li Lan Yang Fang-Yi Quan Shu-Liang Chen Fan Luo Wei Hou Zhan-Qiu Yang Liang-Jun Chen Hai-Rong Xiong Source Type: research
Pathogenicity of novel hantavirus isolate and antigenicity and immunogenicity of novel strain-based inactivated vaccine
CONCLUSIONS: These findings suggest that the inactivated HTNV vaccine may stimulate mice to produce high levels of antibodies with neutralization activity and elicit specific anti-HTNV humoral and cellular immune responses in BALB/c mice against the prevalent strain of HTNV in south central China.PMID:37953099 | DOI:10.1016/j.vaccine.2023.11.017 (Source: Vaccine)
Source: Vaccine - November 12, 2023 Category: Allergy & Immunology Authors: Yuan-Yuan Liu Ying-Qi Xu Yan Zhong Fei Wei Jia-Xin Ling Jin-Lin Li Lan Yang Fang-Yi Quan Shu-Liang Chen Fan Luo Wei Hou Zhan-Qiu Yang Liang-Jun Chen Hai-Rong Xiong Source Type: research
Viruses, Vol. 15, Pages 2238: Seroprevalence of Hantavirus among Manual Cane Cutters and Epidemiological Aspects of HPS in Central Brazil
We described the epidemiological profile of reported hantavirus cases in Goiás—a highly endemic area for HPS, and where the seroepidemiological study was conducted. Our results increase our knowledge about hantavirus infections in Brazil and highlight the vulnerability of sugarcane cutters to a highly lethal disease that, to date, has no specific treatment or vaccination. (Source: Viruses)
Source: Viruses - November 10, 2023 Category: Virology Authors: Renata Malachini Maia Jorlan Fernandes Luciana Helena Bassan Vicente de Mattos Luiz Antonio Bastos Camacho Karlla Antonieta Amorim Caetano Megmar Aparecida dos Santos Carneiro Fernando de Oliveira Santos Sheila Araujo Teles Elba Regina Sampaio de Lemos Re Tags: Article Source Type: research
