GSE226846 Next-generation sequencing analysis of tea plant cultivar transcriptomes in response to Colletotrichum camelliae infection
Contributor : Shouan LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Camellia sinensisNext-generation sequencing (NGS) was performed to identify genes changed in tea plant cultivar Zhongcha 108 upon Colletotrichum camelliae infection. The goal of the work is to find interesting genes involved in tea plant in response to fungi infection. The object is to reveal the molecular mechanism of tea plant defense. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Camellia sinensis Source Type: research
Molecules, Vol. 29, Pages 474: Changes in the Antioxidant Potential of Camellia sinensis Cultures under the Influence of Phenolic Precursors
ia V. Zagoskina
The viability, productivity and survival of higher plants under the adverse factors influence are largely determined by the functional activity of the antioxidant system. The aim of our work was to investigate changes in formation of high-molecular (superoxide dismutase and peroxidase) and low-molecular (phenolics, including flavanols and proanthocyanidins) antioxidants in callus culture of Camellia sinensis under influence of phenolic precursors (L-phenylalanine—3 mM, trans-cinnamic acid—1 mM, naringenin—0.5 mM). According to the data obtained, the effect of pr...
Source: Molecules - January 18, 2024 Category: Chemistry Authors: Maria A. Aksenova Tatiana L. Nechaeva Evgenia A. Goncharuk Maria Y. Zubova Varvara V. Kazantseva Petr V. Lapshin Andrej Frolov Natalia V. Zagoskina Tags: Article Source Type: research
Insights into the functional role of Actinomycetia in promoting plant growth and biocontrol in tea (Camellia sinensis) plants
Arch Microbiol. 2024 Jan 16;206(2):65. doi: 10.1007/s00203-023-03789-1.ABSTRACTTea, a highly aromatic and globally consumed beverage, is derived from the aqueous infusion of dried leaves of Camellia sinensis (L.) O. Kuntze. Northeast India, encompassing an expansive geographical area between 24° and 27° N latitude and 88° and 95° E longitude, is a significant tea-producing region covering approximately 312,210 hectares. Despite its prominence, this region faces persistent challenges owing to a conducive climate that harbors the prevalence of pests, fungal pathogens, and weeds, necessitating agrochemicals. Helopeltis th...
Source: Archives of Microbiology - January 16, 2024 Category: Microbiology Authors: Rictika Das Pranami Bharadwaj Debajit Thakur Source Type: research
Genome-wide characterization of COMT family and regulatory role of CsCOMT19 in melatonin synthesis in Camellia sinensis
Caffeic acid O-methyltransferase (COMT) is a key enzyme that regulates melatonin synthesis and is involved in regulating the growth, development, and response to abiotic stress in plants. Tea plant is a popula... (Source: BMC Plant Biology)
Source: BMC Plant Biology - January 16, 2024 Category: Biology Authors: Thanh Huyen Pham, Xingyu Tian, Huimin Zhao, Tong Li and Litang Lu Tags: Research Source Type: research
Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) - protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
This study addresses the pressing need for non-hormonal, non-surgical treatment options for women with fibroids desiring pregnancy. Previous preclinical and clinical studies have shown that epigallocatechin gallate (EGCG) effectively reduces uterine fibroid size. We hypothesise that EGCG from green tea extract will shrink fibroids, enhance endometrial quality and increase pregnancy likelihood. To investigate this hypothesis, we initiated a National Institute of Child Health and Human Development Confirm-funded trial to assess EGCG’s efficacy in treating women with fibroids and unexplained infertility.
Methods and an...
Source: BMJ Open - January 12, 2024 Category: General Medicine Authors: Al-Hendy, A., Segars, J. H., Taylor, H. S., Gonzalez, F., Siblini, H., Zamah, M., Alkelani, H., Singh, B., Flores, V. A., Christman, G. M., Johnson, J. J., Huang, H., Zhang, H. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Combined treatment of human mesenchymal stem cells and green tea extract on retinal ganglion cell regeneration in rats after optic nerve injury
Exp Eye Res. 2024 Jan 10;239:109787. doi: 10.1016/j.exer.2024.109787. Online ahead of print.ABSTRACTRetinal ganglion cell (RGC) death and axonal loss cause irreversible vision loss upon optic nerve (ON) injury. We have independently demonstrated that mesenchymal stem cells (MSCs) and green tea extract (GTE) promote RGC survival and axonal regeneration in rats with ON injury. Here we aimed to evaluate the combined treatment effect of human bone marrow-derived MSCs (hBM-MSCs) and GTE on RGC survival and axonal regeneration after ON injury. Combined treatment of hBM-MSCs and GTE promoted RGC survival and neurite outgrowth/axo...
Source: Experimental Eye Research - January 11, 2024 Category: Opthalmology Authors: Qichen Yang Yanxuan Xu Xin Bin Kwok Ping Chan Shaowan Chen Zhen Qian Yao Yao Xiang-Ling Yuan Kunliang Qiu Yuqiang Huang Tsz Kin Ng Source Type: research
Bibliometric and visual analysis in the field of tea in cancer from 2013 to 2023
ConclusionTea’s potential as an anti-cancer medication is gaining global recognition. Our study provides a comprehensive analysis of tea-related cancer research from 2013 to 2023, guiding future investigations in this field. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 11, 2024 Category: Cancer & Oncology Source Type: research
Antioxidant activity study and GC-MS profiling of < em > Camellia sinensis < /em > Linn
Heliyon. 2023 Dec 10;10(1):e23514. doi: 10.1016/j.heliyon.2023.e23514. eCollection 2024 Jan 15.ABSTRACTThe antioxidant activity of tea leaves extract is a widely researched topic. Tea leaves, particularly those from the Camellia sinensis Linn plant, have garnered attention due to their potential health benefits attributed to their antioxidant properties. Antioxidants are compounds that can neutralize harmful free radicals in the body, which can damage cells and contribute to various health issues, including cancer, cardiovascular diseases, and aging. In this research, the matured tea leaves which has been considered as agr...
Source: Cancer Control - January 9, 2024 Category: Cancer & Oncology Authors: Md Rashed Hasan Mohammad Majedul Haque Md Amirul Hoque Shahin Sultana Mohammad Mahbubur Rahman Md Aftab Ali Shaikh Md Khabir Uddin Sarker Source Type: research
Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings
Food Chem Toxicol. 2024 Jan 6:114438. doi: 10.1016/j.fct.2024.114438. Online ahead of print.ABSTRACTToxicity testing of botanicals is challenging because of their chemical complexity and variability. Since botanicals may affect many different modes of action involved in neuronal function, we used microelectrode array (MEA) recordings of primary rat cortical cultures to screen 16 different botanical extracts for their effects on cell viability and neuronal network function in vitro. Our results demonstrate that extract materials (50 μg/mL) derived from goldenseal, milk thistle, tripterygium, and yohimbe decrease mitochondr...
Source: Food and Chemical Toxicology - January 8, 2024 Category: Food Science Authors: Regina G D M van Kleef Michelle R Embry Constance A Mitchell Remco H S Westerink Source Type: research
Evaluation of the antibacterial effect of Epigallocatechin gallate on the major pathogens of canine periodontal disease and therapeutic effects on periodontal disease mice
ConclusionOur research demonstrates the significant antibacterial effects of EGCG against the prevalent bacterium P. gulae in canine PD. Moreover, EGCG exhibits anti-inflammatory properties and proves effective in addressing bone loss in a PD mouse model. These findings collectively suggest the therapeutic potential of EGCG in the treatment of canine PD. The outcomes of this study contribute valuable data, laying the foundation for further exploration and screening of alternative antibiotic drugs to advance the management of canine PD. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 5, 2024 Category: Microbiology Source Type: research
EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model
Eur J Med Chem. 2024 Jan 1;265:116098. doi: 10.1016/j.ejmech.2023.116098. Online ahead of print.ABSTRACTOverexpression of the chromosome 21 DYRK1A gene induces morphological defects and cognitive impairments in individuals with Down syndrome (DS) and in DS mice models. Aging neurons of specific brain regions of patients with Alzheimer's disease, DS and Pick's disease have increased DYRK1A immunoreactivity suggesting a possible association of DYRK1A with neurofibrillary tangle pathology. Epigallocatechin-3-gallate (EGCG) displays appreciable inhibition of DYRK1A activity and, contrary to all other published inhibitors, EGCG...
Source: European Journal of Medicinal Chemistry - January 3, 2024 Category: Chemistry Authors: Jean M Delabar Marco Ant ônio G B Gomes Marta Fructuoso Nad ège Sarrazin Nicolas George Nadia Fleary-Roberts Hua Sun Linh Chi Bui Fernando Rodrigues-Lima Nathalie Janel Julien Dairou Edmilson J Maria Robert H Dodd Kevin Cariou Marie-Claude Potier Source Type: research
The effect of ascorbic acid and lemon juice on the extraction of metals from green tea, health risk assessment
. (Source: Toxin Reviews)
Source: Toxin Reviews - January 2, 2024 Category: Toxicology Authors: Melisa Begi ćJasna HuremovićAlisa SelovićAmar KaradžaUniversity of Sarajevo-Faculty of Science, Sarajevo, Bosnia and Herzegovina Source Type: research
Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach
ConclusionThe target-ligand complex of green tea active compound Epigallocatechin gallate with NOTCH (1 –4) had the potential to become potent anti-breast cancer therapeutic candidates following further research involving wet-lab experiments. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research
Green rGO/FeNPs nanocomposites activated peroxydisulfate for the removal of mixed 17 β-estradiol and estriol
In this study, rGO/FeNPs were used to activate peroxydisulfate (PDS) for 17β-estradiol (βE2) and estriol (E3) removal. The rGO/FeNPs-PDS system removed 83.6% of βE2 and 62.5% of E3 within 240 min, which was confirmed by a combination of adsorption and degradation via both radical and non-radical pathways. Four main reactive species in βE2 and E3 degradation were observed, i.e., hydroxyl radical (·OH), sulfate radical (SO4·-), singlet oxygen (1O2) and electron transfer, with the respective contributions of ·OH (32.9 and 34.7%), SO4·- (16.1 and 19.7%), 1O2 (12.2 and 14.1%) and electron transfer (8.0 and 7.2%). Analys...
Source: Environmental Research - December 28, 2023 Category: Environmental Health Authors: Longjie Liu Zeyang Lu Wanling Cai Gary Owens Zuliang Chen Source Type: research
Green rGO/FeNPs nanocomposites activated peroxydisulfate for the removal of mixed 17 β-estradiol and estriol
In this study, rGO/FeNPs were used to activate peroxydisulfate (PDS) for 17β-estradiol (βE2) and estriol (E3) removal. The rGO/FeNPs-PDS system removed 83.6% of βE2 and 62.5% of E3 within 240 min, which was confirmed by a combination of adsorption and degradation via both radical and non-radical pathways. Four main reactive species in βE2 and E3 degradation were observed, i.e., hydroxyl radical (·OH), sulfate radical (SO4·-), singlet oxygen (1O2) and electron transfer, with the respective contributions of ·OH (32.9 and 34.7%), SO4·- (16.1 and 19.7%), 1O2 (12.2 and 14.1%) and electron transfer (8.0 and 7.2%). Analys...
Source: Environmental Research - December 28, 2023 Category: Environmental Health Authors: Longjie Liu Zeyang Lu Wanling Cai Gary Owens Zuliang Chen Source Type: research
