Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease
Neuroreport. 2024 Mar 8. doi: 10.1097/WNR.0000000000002027. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The main bioactive component of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) exerts protective effects against diseases such as neurodegenerative diseases and cancer. Therefore, this study investigated the effect of EGCG on the amelioration of neural damage in a chronic PD mouse model induced by α-synuclein preformed fibrils (α-syn-PFFs). A tot...
Source: Cancer Control - March 25, 2024 Category: Cancer & Oncology Authors: Jianing Shen Junhua Xie Liyuan Ye Jian Mao Shihao Sun Weiwei Chen Sijia Wei Sisi Ruan Linhai Wang Hangcui Hu Jingjing Wei Yao Zheng Zhouyan Xi Ke Wang Yan Xu Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 22:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability of...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Xiaoting Fu Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro
In this study, we evaluated the inhibitory effects of senkyuchachosan, a traditional Japanese medicine, on PLpro of SARS-CoV-2, the virus responsible for causing COVID-19. We purified the PLpro enzyme and conducted in vitro enzymatic assays using specific substrates. Among the nine crude drugs present in senkyuchachosan, four (Cyperi Rhizoma, Schizonepetae Spica, Menthae Herba, and Camelliae sinensis Folium [CsF]) strongly inhibited PLpro activity. CsF, derived fromCamellia sinensis (green tea), contains polyphenols, including catechins and tannins. To confirm that the PLpro inhibitory effects of senkyuchachosan predominan...
Source: Journal of Natural Medicines - March 21, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 1373: Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
This article summarize and highlight the effects of EGCG on cancer hallmarks and focused on the impacts of EGCG on these cancer-related hallmarks. The studies discussed in this review enrich the understanding of EGCG’s potential as a therapeutic tool against cancer, offering a substantial foundation for scientists and medical experts to advance scientific and clinical investigations regarding EGCG’s possibility as a potential anticancer treatment. (Source: Molecules)
Source: Molecules - March 20, 2024 Category: Chemistry Authors: Wamidh H. Talib Dima Awajan Abdelrahim Alqudah Razan Alsawwaf Raha Althunibat Mahmoud Abu AlRoos Ala ’a Al Safadi Sharif Abu Asab Rawan W. Hadi Lina T. Al Kury Tags: Review Source Type: research
Corrigendum to 'Concentrations, leachability, and health risks of mercury in green tea from major production areas in China' Ecotoxicol. Environ. Saf. 232 (2022) 113279
Ecotoxicol Environ Saf. 2024 Mar 18;274:116233. doi: 10.1016/j.ecoenv.2024.116233. Online ahead of print.NO ABSTRACTPMID:38503109 | DOI:10.1016/j.ecoenv.2024.116233 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 19, 2024 Category: Environmental Health Authors: Qingfeng Wang Dan Wang Zhonggen Li Yuyu Wang Yan Yang Mengxun Liu Dadong Li Guangyi Sun Boping Zeng Source Type: research
Decaffeinated green tea polyphenols supplementation had no adverse health effects in girls with obesity: a randomized controlled trial
CONCLUSIONS: This study indicated that the supplementation of 400 mg/d DGTP for 12 weeks had no adverse health effects in girls with obesity, providing evidence for the DGTP adoption in children research.PMID:38494693 | DOI:10.6133/apjcn.202403_33(1).0012 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Die Yao Luyao Xie Kun Du Xinyuan Yao Xiuhua Shen Source Type: research
