Molecules, Vol. 28, Pages 7832: ( & minus;)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice
Molecules, Vol. 28, Pages 7832: (−)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice
Molecules doi: 10.3390/molecules28237832
Authors:
Hong Xu
Xu Zhong
Taotao Wang
Shanshan Wu
Huanan Guan
Dongxu Wang
Perfluorodecanoic acid (PFDA), an enduring and harmful organic pollutant, is widely employed in diverse food-related sectors. Our previous studies have provided evidence that PFDA has the potential to facilitate obesity and hepatic fat accumulation induced by high-fat diet (HFD) intake. Epigallocate...
Source: Molecules - November 28, 2023 Category: Chemistry Authors: Hong Xu Xu Zhong Taotao Wang Shanshan Wu Huanan Guan Dongxu Wang Tags: Article Source Type: research
Dual action of epigallocatechin-3-gallate in virus-induced cell Injury
CONCLUSIONS: The EGCG has proven to be an efficient antiviral against SARS-CoV-2 and HSV-2, as well as a wound-healing phytochemical. We assume that EGCG may be a promising option for slowing the course of acute cellular damage induced by systemic (Coronavirus Disease 2019 (COVID-19)) or topical (HSV-2) viral infections.PMID:38012348 | DOI:10.1186/s43141-023-00624-4 (Source: Herpes)
Source: Herpes - November 27, 2023 Category: Infectious Diseases Authors: Ahmed Mostafa Gomaa Mostafa-Hedeab Hany Abdelfattah Elhady Esraa Ahmed Mohamed Abozer Y Eledrdery Sager Holyl Alruwaili Ahmed Mohamed Al-Abd Abdou Kamal Allayeh Source Type: research
Molecules, Vol. 28, Pages 7775: Azorean Black Tea (Camellia sinensis) Antidermatophytic and Fungicidal Properties
a Gonçalves
The treatment of dermatophytoses, the most common human fungal infections, requires new alternatives. The aim of this study was to determine the antidermatophytic activity of the aqueous Azorean Black Tea extract (ABT), together with an approach to the mechanisms of action. The phytochemical analysis of ABT extract was performed by HPLC. The dermatophytes susceptibility was assessed using a broth microdilution assay; potential synergies with terbinafine and griseofulvin were evaluated by the checkerboard assay. The mechanism of action was appraised by the quantification of the fungal cell wall chitin and &...
Source: Molecules - November 25, 2023 Category: Chemistry Authors: Chantal Fernandes Jos é Sousa-Baptista Ana Filipa Lenha-Silva Daniela Calheiros Edmilson Correia Artur Figueirinha L ígia Salgueiro Teresa Gon çalves Tags: Article Source Type: research
Bioequivalence of 240 mg Apalutamide Tablets and Preparation in Aqueous Food Vehicles for Alternative Administration
AbstractA 240-mg single tablet has been developed with the focus of reducing the pill burden of the apalutamide daily dose of 240 mg (4 × 60-mg tablets). An open-label, randomized, single-dose phase 1 study with a 2-sequence and 2-period crossover design in healthy men determined the bioequivalence of a 240-mg single tablet versus the currently available 4 × 60-mg tablets (Part 1, N = 74) and assessed effect of a high- fat meal (Part 2, N = 21) on apalutamide maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC0-72 h). The 90% confidence interval of geometric mean ratios...
Source: Clinical Pharmacology in Drug Development - November 21, 2023 Category: Drugs & Pharmacology Authors: Alex Yu,
Mieke Van Uffel,
Juhui J. Jiao,
Rosamerlinda Rosales,
Maura Erba,
Nahor Haddish ‐Berhane Tags: Original Article Source Type: research
