Suppression of the Excitability of Rat Nociceptive Secondary Sensory Neurons following Local Administration of the Phytochemical, (-)-Epigallocatechin-3-gallate
Brain Res. 2023 May 29:148426. doi: 10.1016/j.brainres.2023.148426. Online ahead of print.ABSTRACTThe phytochemical, polyphenolic compound, (-)-epigallocatechin-3-gallate (EGCG), is the main catechin found in green tea. Although a modulatory effect of EGCG on voltage-gated sodium and potassium channels has been reported in excitable tissues, the in vivo effect of EGCG on the excitability of nociceptive sensory neurons remains to be determined. Our aim was to investigate whether local administration of EGCG to rats attenuates the excitability of nociceptive spinal trigeminal nucleus caudalis (SpVc) neurons in response to me...
Source: Brain Research - May 31, 2023 Category: Neurology Authors: Mizuho Uchino Yukito Sashide Mamoru Takeda Source Type: research
The heavy metal-associated isoprenylated plant protein (HIPP) gene family plays a crucial role in cadmium resistance and accumulation in the tea plant (Camellia sinensis L.)
In this study, we systematically identified 56C. sinensis CsHIPP genes from five groups and characterized their phylogeny, structures, and the features of the encoded proteins. The expression patterns of CsHIPP genes in various tissues of C. sinensis were investigated based on a previous RNA-seq data analysis. The expression patterns of CsHIPP genes were explored in cadmium (Cd)-treated C. sinensis roots using our RNA-seq data. Three CsHIPP genes (CsHIPP22, CsHIPP24, and CsHIPP36) with high expression levels in Cd-treated C. sinensis roots were selected as candidate genes associated with Cd tolerance. Overexpression of CsH...
Source: Ecotoxicology and Environmental Safety - May 31, 2023 Category: Environmental Health Authors: Yunfeng Wei Xuqian Peng Xiaojing Wang Cheng Wang Source Type: research
Suppression of the Excitability of Rat Nociceptive Secondary Sensory Neurons following Local Administration of the Phytochemical, (-)-Epigallocatechin-3-gallate
Brain Res. 2023 May 29:148426. doi: 10.1016/j.brainres.2023.148426. Online ahead of print.ABSTRACTThe phytochemical, polyphenolic compound, (-)-epigallocatechin-3-gallate (EGCG), is the main catechin found in green tea. Although a modulatory effect of EGCG on voltage-gated sodium and potassium channels has been reported in excitable tissues, the in vivo effect of EGCG on the excitability of nociceptive sensory neurons remains to be determined. Our aim was to investigate whether local administration of EGCG to rats attenuates the excitability of nociceptive spinal trigeminal nucleus caudalis (SpVc) neurons in response to me...
Source: Brain Research - May 31, 2023 Category: Neurology Authors: Mizuho Uchino Yukito Sashide Mamoru Takeda Source Type: research
The heavy metal-associated isoprenylated plant protein (HIPP) gene family plays a crucial role in cadmium resistance and accumulation in the tea plant (Camellia sinensis L.)
In this study, we systematically identified 56C. sinensis CsHIPP genes from five groups and characterized their phylogeny, structures, and the features of the encoded proteins. The expression patterns of CsHIPP genes in various tissues of C. sinensis were investigated based on a previous RNA-seq data analysis. The expression patterns of CsHIPP genes were explored in cadmium (Cd)-treated C. sinensis roots using our RNA-seq data. Three CsHIPP genes (CsHIPP22, CsHIPP24, and CsHIPP36) with high expression levels in Cd-treated C. sinensis roots were selected as candidate genes associated with Cd tolerance. Overexpression of CsH...
Source: Ecotoxicology and Environmental Safety - May 31, 2023 Category: Environmental Health Authors: Yunfeng Wei Xuqian Peng Xiaojing Wang Cheng Wang Source Type: research
Inflammation inhibitory activity of green tea, soybean, and guava extracts during Sars-Cov-2 infection through TNF protein in cytokine storm
Comput Biol Chem. 2023 May 23;105:107898. doi: 10.1016/j.compbiolchem.2023.107898. Online ahead of print.ABSTRACTCoronavirus disease is caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) known as COVID-19. COVID-19 has caused the deaths of 6,541,936 people worldwide as of September 27th, 2022. SARS-CoV-2 severity is determined by a cytokine storm condition, in which the innate immune system creates an unregulated and excessive production of pro-inflammatory such IL-1, IL-6, NF Kappa B, and TNF alpha signaling molecules known as cytokines. The patient died due to respiratory organ failure an...
Source: Computational Biology and Chemistry - May 29, 2023 Category: Bioinformatics Authors: Didik Priyandoko Wahyu Widowati Hanna Sari Widya Kusuma Ervi Afifah Cahyaning Riski Wijayanti Rizal Rizal Ika Adhani Sholihah Galuh Wening Permatasari Anggia Ramadhani Didik Huswo Utomo Source Type: research
Inflammation inhibitory activity of green tea, soybean, and guava extracts during Sars-Cov-2 infection through TNF protein in cytokine storm
Comput Biol Chem. 2023 May 23;105:107898. doi: 10.1016/j.compbiolchem.2023.107898. Online ahead of print.ABSTRACTCoronavirus disease is caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) known as COVID-19. COVID-19 has caused the deaths of 6,541,936 people worldwide as of September 27th, 2022. SARS-CoV-2 severity is determined by a cytokine storm condition, in which the innate immune system creates an unregulated and excessive production of pro-inflammatory such IL-1, IL-6, NF Kappa B, and TNF alpha signaling molecules known as cytokines. The patient died due to respiratory organ failure an...
Source: Computational Biology and Chemistry - May 29, 2023 Category: Bioinformatics Authors: Didik Priyandoko Wahyu Widowati Hanna Sari Widya Kusuma Ervi Afifah Cahyaning Riski Wijayanti Rizal Rizal Ika Adhani Sholihah Galuh Wening Permatasari Anggia Ramadhani Didik Huswo Utomo Source Type: research
Colorimetric sensor array based on Au < sub > 2 < /sub > Pt nanozymes for antioxidant nutrition quality evaluation in food
Biosens Bioelectron. 2023 May 22;236:115417. doi: 10.1016/j.bios.2023.115417. Online ahead of print.ABSTRACTTotal antioxidant capacity (TAC) has become an important index to evaluate the food quality. Effective antioxidant detection has been the research hotspot of scientists. In this work, a novel three-channel colorimetric sensor array founded on Au2Pt bimetallic nanozymes for the discrimination of antioxidants in food was constructed. Benefiting from the unique bimetallic doping structure, Au2Pt nanospheres exhibited the excellent peroxidase-like activity with Km of 0.044 mM and Vmax of 19.37 × 10-8 M s-1 toward TMB. T...
Source: Biosensors and Bioelectronics - May 27, 2023 Category: Biotechnology Authors: Fengling Wu Hongsu Wang Jianhui Lv Xiaomei Shi Lifang Wu Xiaodi Niu Source Type: research
Colorimetric sensor array based on Au < sub > 2 < /sub > Pt nanozymes for antioxidant nutrition quality evaluation in food
Biosens Bioelectron. 2023 May 22;236:115417. doi: 10.1016/j.bios.2023.115417. Online ahead of print.ABSTRACTTotal antioxidant capacity (TAC) has become an important index to evaluate the food quality. Effective antioxidant detection has been the research hotspot of scientists. In this work, a novel three-channel colorimetric sensor array founded on Au2Pt bimetallic nanozymes for the discrimination of antioxidants in food was constructed. Benefiting from the unique bimetallic doping structure, Au2Pt nanospheres exhibited the excellent peroxidase-like activity with Km of 0.044 mM and Vmax of 19.37 × 10-8 M s-1 toward TMB. T...
Source: Biosensors and Bioelectronics - May 27, 2023 Category: Biotechnology Authors: Fengling Wu Hongsu Wang Jianhui Lv Xiaomei Shi Lifang Wu Xiaodi Niu Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
Anti-Inflammatory and Anti-Quorum Sensing Effect of < em > Camellia sinensis < /em > Callus Lysate for Treatment of Acne
Curr Issues Mol Biol. 2023 May 4;45(5):3997-4016. doi: 10.3390/cimb45050255.ABSTRACTCutibacterium acnes (C. acnes) is involved in the pathogenesis of acne by inducing inflammation and biofilm formation, along with other virulence factors. A Camellia sinensis (C. sinensis) callus lysate is proposed to reduce these effects. The aim of the present work is to study the anti-inflammatory properties of a callus extract from C. sinensis on C. acnes-stimulated human keratinocytes and the quorum-quenching activities. Keratinocytes were stimulated with thermo-inactivated pathogenic C. acnes and were treated with the herbal lysate (0...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mariona Ca ñellas-Santos Elisabet Rosell-Vives Laia Montell Ainhoa Bilbao Felipe Go ñi-de-Cerio Francisco Fernandez-Campos Source Type: research
