Green rGO/FeNPs nanocomposites activated peroxydisulfate for the removal of mixed 17 β-estradiol and estriol
In this study, rGO/FeNPs were used to activate peroxydisulfate (PDS) for 17β-estradiol (βE2) and estriol (E3) removal. The rGO/FeNPs-PDS system removed 83.6% of βE2 and 62.5% of E3 within 240 min, which was confirmed by a combination of adsorption and degradation via both radical and non-radical pathways. Four main reactive species in βE2 and E3 degradation were observed, i.e., hydroxyl radical (·OH), sulfate radical (SO4·-), singlet oxygen (1O2) and electron transfer, with the respective contributions of ·OH (32.9 and 34.7%), SO4·- (16.1 and 19.7%), 1O2 (12.2 and 14.1%) and electron transfer (8.0 and 7.2%). Analys...
Source: Environmental Research - December 28, 2023 Category: Environmental Health Authors: Longjie Liu Zeyang Lu Wanling Cai Gary Owens Zuliang Chen Source Type: research
Epigallocatechin ‐3‐gallate attenuates arsenic‐induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, is known to have antioxidant and epigenetic modulation properties. Whether EGCG, through its antioxidant and epigenetic modulating activities, can attenuate fibrogenesis is not known. In this context, the novel findings of this study suggest that EGCG, through its antioxidant and epigenetic modulation capacities, has protective effects against arsenic-induced cytotoxicity and fibrogenic changes in kidney epithelial cells. AbstractRenal fibrosis is a pathogenic intermediate stage of chronic kidney disease (CKD). Nephrotoxicants including arsenic can cause kidney fib...
Source: BioFactors - December 26, 2023 Category: Biochemistry Authors: Mary Sonia Iheanacho,
Ramji Kandel,
Priti Roy,
Kamaleshwar P. Singh Tags: RESEARCH ARTICLE Source Type: research
Impact of internal metal ions in tea polysaccharides on antioxidant potential and suppression of cancer cell growth
Fitoterapia. 2023 Dec 20:105786. doi: 10.1016/j.fitote.2023.105786. Online ahead of print.ABSTRACTFour kinds of tea polysaccharides (MBTPS, MGTPS, ZBTPS, ZGTPS) were extracted from Maofeng black tea, Maofeng green tea,Ziyan black tea and Ziyan green tea, and then four tea polysaccharides (RMBTPS, RMGTPS, RZBTPS, RZGTPS) after metal removal were prepared. The physicochemical properties, antioxidant activity and inhibitory activity on cancer cell proliferation of the above polysaccharides were studied. The composition analysis shows that these tea polysaccharides were glycoproteins complexes, composed of a variety of monosac...
Source: Fitoterapia - December 22, 2023 Category: Biochemistry Authors: Gang Xiang Huaping Sun Qian Tang Aimin Wu Shengxiang Chen Jiali Mao Changfang Lu Xianxiang Wang Source Type: research
Impact of internal metal ions in tea polysaccharides on antioxidant potential and suppression of cancer cell growth
Fitoterapia. 2023 Dec 20:105786. doi: 10.1016/j.fitote.2023.105786. Online ahead of print.ABSTRACTFour kinds of tea polysaccharides (MBTPS, MGTPS, ZBTPS, ZGTPS) were extracted from Maofeng black tea, Maofeng green tea,Ziyan black tea and Ziyan green tea, and then four tea polysaccharides (RMBTPS, RMGTPS, RZBTPS, RZGTPS) after metal removal were prepared. The physicochemical properties, antioxidant activity and inhibitory activity on cancer cell proliferation of the above polysaccharides were studied. The composition analysis shows that these tea polysaccharides were glycoproteins complexes, composed of a variety of monosac...
Source: Fitoterapia - December 22, 2023 Category: Biochemistry Authors: Gang Xiang Huaping Sun Qian Tang Aimin Wu Shengxiang Chen Jiali Mao Changfang Lu Xianxiang Wang Source Type: research
Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns
Green tea, a popular and healthy nonalcoholic drink consumed globally, is abundant in natural polyphenols. One of these polyphenols is epigallocatechin-3-gallate (EGCG), which offers a range of health benefits... (Source: Cancer Cell International)
Source: Cancer Cell International - December 21, 2023 Category: Cancer & Oncology Authors: Guichun Wang, Jinyi Wang and Mohammad Reza Momeni Tags: Review Source Type: research
Protein S-palmitoylation is markedly inhibited by 4 ″-alkyl ether lipophilic derivatives of EGCG, the major green tea polyphenol: In vitro and in silico studies
Biochim Biophys Acta Biomembr. 2023 Dec 15:184264. doi: 10.1016/j.bbamem.2023.184264. Online ahead of print.ABSTRACTS-palmitoylation is a dynamic lipid-based protein post-translational modification facilitated by a family of protein acyltransferases (PATs) commonly known as DHHC-PATs or DHHCs. It is the only lipid modification that is reversible, and this very fact uniquely qualifies it for therapeutic interventions through the development of DHHC inhibitors. Herein, we report that 4″-alkyl ether lipophilic derivatives of EGCG can effectively inhibit protein S-palmitoylation in vitro. With the help of metabolic labeling ...
Source: Biochimica et Biophysica Acta - December 17, 2023 Category: Biochemistry Authors: Anupama Binoy Manan Kothari Revathy Sahadevan Sayan Poddar Parimal Kar Sushabhan Sadhukhan Source Type: research
Protein S-palmitoylation is markedly inhibited by 4 ″-alkyl ether lipophilic derivatives of EGCG, the major green tea polyphenol: In vitro and in silico studies
Biochim Biophys Acta Biomembr. 2023 Dec 15:184264. doi: 10.1016/j.bbamem.2023.184264. Online ahead of print.ABSTRACTS-palmitoylation is a dynamic lipid-based protein post-translational modification facilitated by a family of protein acyltransferases (PATs) commonly known as DHHC-PATs or DHHCs. It is the only lipid modification that is reversible, and this very fact uniquely qualifies it for therapeutic interventions through the development of DHHC inhibitors. Herein, we report that 4″-alkyl ether lipophilic derivatives of EGCG can effectively inhibit protein S-palmitoylation in vitro. With the help of metabolic labeling ...
Source: Biochimica et Biophysica Acta - December 17, 2023 Category: Biochemistry Authors: Anupama Binoy Manan Kothari Revathy Sahadevan Sayan Poddar Parimal Kar Sushabhan Sadhukhan Source Type: research
Viruses, Vol. 15, Pages 2447: Pre-Clinical Evaluation of the Antiviral Activity of Epigalocatechin-3-Gallate, a Component of Green Tea, against Influenza A(H1N1)pdm Viruses
This study aimed to explore the antiviral efficacy of EGCG in vitro and in ferrets. We first performed studies in Madin-Darby Canine Kidney (MDCK) and human lung carcinoma (Calu-3) cells, which demonstrated antiviral activity. In MDCK cells, we observed a selective index (SI, CC50/IC50) of 77 (290 µM/3.8 µM) and 96 (290 µM/3.0 µM) against A/California/07/2009 and A/Victoria/2570/2019 (H1N1)pdm09 influenza virus, respectively. Calu-3 cells demonstrated a SI of 16 (420 µM/26 µM) and 18 (420 µM/24 µM). Ferrets infec...
Source: Viruses - December 16, 2023 Category: Virology Authors: Harry Stannard Paulina Koszalka Nikita Deshpande Yves Desjardins Mariana Baz Tags: Article Source Type: research
Tea seed saponin ‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells
Mol Med Rep. 2024 Feb;29(2):26. doi: 10.3892/mmr.2023.13149. Epub 2023 Dec 15.ABSTRACTTea (Camellia sinensis) seed cake is a potential resource that contains a wealth of bioactive compounds. However, the high toxicity of tea saponins in tea seed cake restricts its applications. The present study aimed to i) develop a method of extracting bioactive compounds and reducing tea saponins during the process of tea seed cake extraction and ii) investigate the anti‑insulin resistance effect of tea seed saponin‑reduced extract (TSSRE) in a palmitic acid (PA)‑induced insulin resistance HepG2‑cell model. The concentration of ...
Source: Molecular Medicine - December 15, 2023 Category: Molecular Biology Authors: Shu-Chi Cho Shyh-Yu Shaw Source Type: research
Tea seed saponin ‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells
Mol Med Rep. 2024 Feb;29(2):26. doi: 10.3892/mmr.2023.13149. Epub 2023 Dec 15.ABSTRACTTea (Camellia sinensis) seed cake is a potential resource that contains a wealth of bioactive compounds. However, the high toxicity of tea saponins in tea seed cake restricts its applications. The present study aimed to i) develop a method of extracting bioactive compounds and reducing tea saponins during the process of tea seed cake extraction and ii) investigate the anti‑insulin resistance effect of tea seed saponin‑reduced extract (TSSRE) in a palmitic acid (PA)‑induced insulin resistance HepG2‑cell model. The concentration of ...
Source: Molecular Medicine Reports - December 15, 2023 Category: Molecular Biology Authors: Shu-Chi Cho Shyh-Yu Shaw Source Type: research
Tea seed saponin ‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells
Mol Med Rep. 2024 Feb;29(2):26. doi: 10.3892/mmr.2023.13149. Epub 2023 Dec 15.ABSTRACTTea (Camellia sinensis) seed cake is a potential resource that contains a wealth of bioactive compounds. However, the high toxicity of tea saponins in tea seed cake restricts its applications. The present study aimed to i) develop a method of extracting bioactive compounds and reducing tea saponins during the process of tea seed cake extraction and ii) investigate the anti‑insulin resistance effect of tea seed saponin‑reduced extract (TSSRE) in a palmitic acid (PA)‑induced insulin resistance HepG2‑cell model. The concentration of ...
Source: Molecular Medicine - December 15, 2023 Category: Molecular Biology Authors: Shu-Chi Cho Shyh-Yu Shaw Source Type: research
Tea seed saponin ‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells
Mol Med Rep. 2024 Feb;29(2):26. doi: 10.3892/mmr.2023.13149. Epub 2023 Dec 15.ABSTRACTTea (Camellia sinensis) seed cake is a potential resource that contains a wealth of bioactive compounds. However, the high toxicity of tea saponins in tea seed cake restricts its applications. The present study aimed to i) develop a method of extracting bioactive compounds and reducing tea saponins during the process of tea seed cake extraction and ii) investigate the anti‑insulin resistance effect of tea seed saponin‑reduced extract (TSSRE) in a palmitic acid (PA)‑induced insulin resistance HepG2‑cell model. The concentration of ...
Source: Molecular Medicine Reports - December 15, 2023 Category: Molecular Biology Authors: Shu-Chi Cho Shyh-Yu Shaw Source Type: research
