SOX4 regulates proliferation and apoptosis of human ovarian granulosa-like tumor cell line KGN through the Hippo pathway
Biochem Biophys Res Commun. 2024 Feb 27;705:149738. doi: 10.1016/j.bbrc.2024.149738. Online ahead of print.ABSTRACTThe proliferation and apoptosis of ovarian granulosa cells are important for folliculogenesis. As a transcription factor, SRY-box transcription factor 4 (SOX4) has important roles in regulating cellular proliferation and apoptosis. Nonetheless, the regulatory mechanisms of SOX4 on proliferation and apoptosis of granulosa cells remain elusive. Therefore, a stably overexpressed SOX4 ovarian granulosa cell line KGN was generated by lentivirus encapsulation. We observed that overexpression of SOX4 inhibits apoptos...
Source: Biochemical and Biophysical Research communications - March 6, 2024 Category: Biochemistry Authors: Qiang Hong Mengmeng Fan Rui Cai Wenhui Shi Fenfen Xie Yuanhua Chen Cong Li Source Type: research
The detailed histopathological characteristics of ovarian fibroma compared with thecoma, granulosa cell tumor, and sclerosing stromal tumor
CONCLUSION: Ovarian fibromas can present some maybe unexpected features rather frequently, such as cystic degeneration, hyaline plaques, prominent vascularity, increased cellularity, and some mitotic activity, thus their presence should not always prompt to an alternative diagnosis.PMID:38447489 | DOI:10.1016/j.prp.2024.155236 (Source: Cell Research)
Source: Cell Research - March 6, 2024 Category: Cytology Authors: Mousa Mobarki Alexandra Papoudou-Bai Shaqraa Musawi Michel P éoc'h Georgia Karpathiou Source Type: research
SOX4 regulates proliferation and apoptosis of human ovarian granulosa-like tumor cell line KGN through the Hippo pathway
Biochem Biophys Res Commun. 2024 Feb 27;705:149738. doi: 10.1016/j.bbrc.2024.149738. Online ahead of print.ABSTRACTThe proliferation and apoptosis of ovarian granulosa cells are important for folliculogenesis. As a transcription factor, SRY-box transcription factor 4 (SOX4) has important roles in regulating cellular proliferation and apoptosis. Nonetheless, the regulatory mechanisms of SOX4 on proliferation and apoptosis of granulosa cells remain elusive. Therefore, a stably overexpressed SOX4 ovarian granulosa cell line KGN was generated by lentivirus encapsulation. We observed that overexpression of SOX4 inhibits apoptos...
Source: Cell Research - March 6, 2024 Category: Cytology Authors: Qiang Hong Mengmeng Fan Rui Cai Wenhui Shi Fenfen Xie Yuanhua Chen Cong Li Source Type: research
The detailed histopathological characteristics of ovarian fibroma compared with thecoma, granulosa cell tumor, and sclerosing stromal tumor
CONCLUSION: Ovarian fibromas can present some maybe unexpected features rather frequently, such as cystic degeneration, hyaline plaques, prominent vascularity, increased cellularity, and some mitotic activity, thus their presence should not always prompt to an alternative diagnosis.PMID:38447489 | DOI:10.1016/j.prp.2024.155236 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 6, 2024 Category: Pathology Authors: Mousa Mobarki Alexandra Papoudou-Bai Shaqraa Musawi Michel P éoc'h Georgia Karpathiou Source Type: research
SOX4 regulates proliferation and apoptosis of human ovarian granulosa-like tumor cell line KGN through the Hippo pathway
Biochem Biophys Res Commun. 2024 Feb 27;705:149738. doi: 10.1016/j.bbrc.2024.149738. Online ahead of print.ABSTRACTThe proliferation and apoptosis of ovarian granulosa cells are important for folliculogenesis. As a transcription factor, SRY-box transcription factor 4 (SOX4) has important roles in regulating cellular proliferation and apoptosis. Nonetheless, the regulatory mechanisms of SOX4 on proliferation and apoptosis of granulosa cells remain elusive. Therefore, a stably overexpressed SOX4 ovarian granulosa cell line KGN was generated by lentivirus encapsulation. We observed that overexpression of SOX4 inhibits apoptos...
Source: Biochemical and Biophysical Research communications - March 6, 2024 Category: Biochemistry Authors: Qiang Hong Mengmeng Fan Rui Cai Wenhui Shi Fenfen Xie Yuanhua Chen Cong Li Source Type: research
A clinicopathological study about the epidemiology of granulosa cell tumors in Lebanon
Granulosa Cell Tumors (GCT) are considered the most frequent type of sex-cord stromal tumors. These tumors constitute 3-6% of neoplasms of the ovaries. GCTs are divided into 2 types: Juvenile GCT (JGCT) and Ad... (Source: BMC Cancer)
Source: BMC Cancer - March 6, 2024 Category: Cancer & Oncology Authors: Sana Yaacoub, Labib Hajj and Aya Khairallah Tags: Research Source Type: research
Exploring the histogenesis of STK11 adnexal tumour using electron microscopy
We report the ultrastructural features of two STK11 adnexal tumours and compare their ultrastructural features with those of other sex cord stromal tumours, a granulosa cell tumour cell line, as well as the known ultrastructural features of epithelial, mesothelial and Wolffian cells. On ultrastructural examination, two STK11 adnexal tumours showed an admixture of elongated cells with regular elongated nuclei and polygonal cells with nuclei showing markedly irregular outlines and prominent nucleoli. Extracellular collagen fibres were identified. These are common ultrastructural features of sex cord stromal tumours, principa...
Source: Virchows Archiv - February 20, 2024 Category: Pathology Source Type: research
Complete reduction surgery of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy
We report a patient who underwent complete resection of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy. A 72-year-old woman underwent prima ry surgery for an adult granulosa cell tumor 19 years earlier. A huge recurrent tumor, 11 × 10 cm in size, was noted to elevate the hepatic hilum, inferior vena cava, and right renal vein. The recurrent tumor was too large to resect, thus paclitaxel and carboplatin were administered as neoadj uvant chemotherapy. The tumor shrank to 6 × 5 cm after 6 cycles of chemotherapy, then complete tumor extirpation with resection of the right kidney and tem...
Source: International Cancer Conference Journal - February 14, 2024 Category: Cancer & Oncology Source Type: research
Lycopene mitigates DHT-induced apoptosis and oxidative stress in human granulosa cell line KGN by regulating the Nrf2 pathway
ConclusionIn summary, this work revealed that lycopene alleviates oxidative stress and apoptosis in KGN cells in the presence of DHT, which at least partly by depending on the activation of Nrf2 cascade signal at the molecular level. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 5, 2024 Category: Cytology Source Type: research
Identification and validation of senescence-related genes in polycystic ovary syndrome
CONCLUSIONS: Our work aimed to elucidate the relation between PCOS and cellular senescence based on bioinformatics strategy, deepening the understanding of mechanisms and to seek for novel therapy strategies for improving reproductive lifespan and female health. Exploring the potential molecular mechanism of cell aging in PCOS is expected to bring a new breakthrough for PCOS diagnosis and therapy strategies. And this, might deepen our understanding about intricate mechanisms of ovarian aging.PMID:38184636 | DOI:10.1186/s13048-023-01338-4 (Source: Cell Research)
Source: Cell Research - January 6, 2024 Category: Cytology Authors: Danni Jiang Yang Xu Lin Yang Pengfei Li Xiaojuan Han Qianni Li Yang Yang Lan Chao Source Type: research
Serial cytoreductive surgery and survival outcomes in recurrent adult-type ovarian granulosa cell tumors
Few studies have evaluated the role of cytoreductive surgery in patients with recurrent adult granulosa cell tumors of the ovary. Despite a multitude of treatment modalities in the recurrent setting, the optimal management strategy is not known. Cytoreductive surgery offers an attractive option for disease confined to the abdomen/pelvis. However, few studies have evaluated the role of surgery compared to systemic therapy alone following the first recurrence and subsequent disease progressions. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 6, 2024 Category: OBGYN Authors: Jeffrey A. How, Alejandra Flores Legarreta, Katelyn F. Handley, Bryan Fellman, Katherine I. Foster, Deanna Glassman, Veena K. Vuttaradhi, Allison L. Brodsky, Barrett Lawson, Michael Frumovtiz, Shannon N. Westin, Lois M. Ramondetta, David M. Gershenson, An Tags: Original Research: Gynecology Source Type: research
GSE233313 Effects of oocyte-specific PIK3CA* transgene knock-in in ovaries
Contributor : So-Youn KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the transcriptomic changes during the development and growth of ovarian granulosa cell tumors derived by oocyte-specific PIK3CA* transgene overexpression (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Prognostic factors of adult granulosa cell tumors of the ovary: a Turkish retrospective multicenter study
CONCLUSION: In this study, lymph node involvement was detected in 3.3% of patients with AGCT. Therefore, it was concluded that lymphadenectomy can be avoided in primary surgical treatment. Positive peritoneal cytology, stage, and menopausal status were independent prognostic predictors of DFS.PMID:38156722 | DOI:10.3802/jgo.2024.35.e39 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 29, 2023 Category: OBGYN Authors: Okan Oktar Vakkas Korkmaz Alp Tokal ıoÄŸlu ÇaÄŸatayhan Öztürk Özgür ErdoÄŸan Ye ÅŸim Uçar Hande Esra Koca Y ıldırım Candost Hanedan Fatih K ılıç Burak Ersak Necim Yal çın Fatma Özmen Alper Kahraman Selin Akt ürk Esen Sevda Ba ÅŸ Emel Do Ä Source Type: research
