34. Atypical Presentation of Granulosa Cell Tumor in an Adolescent: A Case Report
Granulosa cell tumors are rare, accounting for approximately 1-2% of all ovarian tumors across age groups and 10-20% of ovarian tumors in the pediatric population. Both juvenile- and adult-type granulosa cell tumors typically induce a hyperestrogenic state that may present as precocious puberty in the prepubertal female or as abnormal uterine bleeding in the postpubertal female. These tumors also often secrete elevated levels of inhibin B, which can be used to aid in diagnosis and in following clinical response to treatment. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 11, 2023 Category: OBGYN Authors: Aimee Morrison, Joseph Pressey, Lauryn P. Roth, Viktoriya Tulchinskaya, Tara Strieich-TIlles Source Type: research
Clinical outcomes of leuprolide acetate in the treatment of recurrent ovarian granulosa cell tumors
The optimal treatment of recurrent ovarian granulosa cell tumors is not known. Pre-clinical studies and small case series have suggested direct anti-tumor activity of gonadotropin-releasing hormone agonists in the treatment of this disease, but little is known about the efficacy and safety of this approach. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 9, 2023 Category: OBGYN Authors: Katherine I. Foster, Alejandra Flores legarreta, Rhea Kamat, Katelyn F. Handley, Deanna Glassman, Jeffrey A. How, Barrett C. Lawson, Shannon N. Westin, Lois M. Ramondetta, Michael Frumovitz, David M. Gershenson, Anil K. Sood, R. Tyler Hillman Tags: Original Research: Gynecology Source Type: research
Advanced adult granulosa cell tumor with prominent fibromatous stroma: A case report
Asian J Surg. 2023 Mar 4:S1015-9584(23)00298-1. doi: 10.1016/j.asjsur.2023.02.125. Online ahead of print.NO ABSTRACTPMID:36878777 | DOI:10.1016/j.asjsur.2023.02.125 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 6, 2023 Category: Surgery Authors: Nermina Ibisevic Nadina Jakirlic Halebic Dalma Udovicic-Gagula Senad Murtezic Semir Vranic Source Type: research
Advanced adult granulosa cell tumor with prominent fibromatous stroma: A case report
Asian J Surg. 2023 Mar 4:S1015-9584(23)00298-1. doi: 10.1016/j.asjsur.2023.02.125. Online ahead of print.NO ABSTRACTPMID:36878777 | DOI:10.1016/j.asjsur.2023.02.125 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 6, 2023 Category: Surgery Authors: Nermina Ibisevic Nadina Jakirlic Halebic Dalma Udovicic-Gagula Senad Murtezic Semir Vranic Source Type: research
Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary - a review
J Ovarian Res. 2023 Mar 3;16(1):50. doi: 10.1186/s13048-023-01125-1.ABSTRACTBACKGROUND: Granulosa cell tumors (GCT) are rare malignant ovarian tumors. The two subtypes, adult and juvenile granulosa cell tumors, differ in clinical and molecular characteristics. GCT are low-malignant tumors and are generally associated with favorable prognosis. However, relapses are common even years and decades after diagnosis. Prognostic and predictive factors are difficult to assess in this rare tumor entity. The purpose of this review is to provide a comprehensive overview of the current state of knowledge on prognostic markers of GCT to...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Dennis Jung Katrin Almstedt Marco J Battista Alexander Seeger J örg Jäkel Walburgis Brenner Annette Hasenburg Source Type: research
Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary - a review
J Ovarian Res. 2023 Mar 3;16(1):50. doi: 10.1186/s13048-023-01125-1.ABSTRACTBACKGROUND: Granulosa cell tumors (GCT) are rare malignant ovarian tumors. The two subtypes, adult and juvenile granulosa cell tumors, differ in clinical and molecular characteristics. GCT are low-malignant tumors and are generally associated with favorable prognosis. However, relapses are common even years and decades after diagnosis. Prognostic and predictive factors are difficult to assess in this rare tumor entity. The purpose of this review is to provide a comprehensive overview of the current state of knowledge on prognostic markers of GCT to...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Dennis Jung Katrin Almstedt Marco J Battista Alexander Seeger J örg Jäkel Walburgis Brenner Annette Hasenburg Source Type: research
TFE3 is a Novel Biomarker of Ovarian Sclerosing Stromal Tumours
Res Sq. 2023 Feb 13:rs.3.rs-2563971. doi: 10.21203/rs.3.rs-2563971/v1. Preprint.ABSTRACTSclerosing stromal tumours of the ovary are benign and tend to occur in young women with lobular structures at low frequencies. Three types of cells, luteinized cells, short spindle myoid cells, and intermediate cells, are found in lobules, which are rich in blood vessels. Currently, immunohistochemistry and fluorescence in situ hybridization are used to detect normal follicles, sclerosing stromal tumours, granulosa cell tumours, and theca fibromas. Our research found the expression of transcription factor enhancer 3 (TFE3) was moderate...
Source: Cell Research - February 24, 2023 Category: Cytology Authors: Li Zhao Yan Zhou Yuping Liu Qiuping Luo Qingping Jiang Hui Wang Na Wang Source Type: research
Adult granulosa cell tumour of the ovary incidentally discovered during caesarean section in a pregnant patient after IVF: a rare case and a review of the literature
In conclusion, AGCTs of the ovary are very rare during pregnancy. Pre-operative diagnosis is difficult. Conservative surgery should be considered in women who wish to have children. Patients should receive adequate counselling and long-term follow-up to ensure the highest survival rates and early detection of recurrence.PMID:36816784 | PMC:PMC9937067 | DOI:10.3332/ecancer.2023.1496 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - February 23, 2023 Category: Cancer & Oncology Authors: Kong Chi Pham Phuong Thi Minh Ta Nhat Minh Huynh Source Type: research
