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Estrogen receptor beta expression and role in cancers
J Steroid Biochem Mol Biol. 2024 Apr 22:106526. doi: 10.1016/j.jsbmb.2024.106526. Online ahead of print.ABSTRACTEstrogen drives the growth of some cancers, such as breast cancer, via estrogen receptor alpha (ERβ). Estrogen also activates ERβ, but whether ERβ is expressed and has a role in different cancers is debated. The use of nonspecific antibodies has contributed to the confusion, and this review delves into ERβ's controversial role in cancer and focuses on tumor expression that can be supported by non-antibody-dependent assays. We discuss its expression at the transcript level and focus on its potential role in ly...
Source: Mol Biol Cell - April 24, 2024 Category: Molecular Biology Authors: F átima L Monteiro Lina Stepanauskaite Amena Archer Cecilia Williams Source Type: research

Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway
CONCLUSION: hUMSC-Exos inhibit ferroptosis and protect against CTX-induced ovarian damage and granulosa cell apoptosis through the Nrf2/GPX4 signaling pathway, revealing a novel mechanism of hUMSC-Exos in POI therapy.PMID:38622725 | DOI:10.1186/s13048-024-01403-6 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Yuan Zhou Jinfa Huang Lingling Zeng Qian Yang Fangjuan Bai Qiqing Mai Kaixian Deng Source Type: research

Mechanism of resveratrol in protecting ovary in poor ovarian response mice by regulating Hippo signaling pathway
In conclusion, Res effectively inhibits ovarian cell apoptosis in mice and improves ovarian responsiveness. Its mechanism may be related to the regulation of key molecules in the Hippo pathway.PMID:38621878 | DOI:10.19540/j.cnki.cjcmm.20230915.401 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Jian-Heng Hao Bo-Ya Chang Jia Ren Hai-Jun Wang Lai-Xi Ji Source Type: research

Efficacy and safety of mesenchymal stem cell therapy for ovarian ageing in a mouse model
CONCLUSIONS: Orthotopic transplantation of MSCs displays significant efficacy and high safety for the treatment of ovarian ageing in mice.PMID:38570892 | DOI:10.1186/s13287-024-03698-0 (Source: Cell Research)
Source: Cell Research - April 3, 2024 Category: Cytology Authors: Wendi Pei Lin Fu Wenhuan Guo Yibo Wang Yong Fan Rui Yang Rong Li Jie Qiao Yang Yu Source Type: research

Giant adult granulosa cell tumor and "atypical" Meigs syndrome: A case report
Asian J Surg. 2024 Mar 23:S1015-9584(24)00494-9. doi: 10.1016/j.asjsur.2024.03.064. Online ahead of print.NO ABSTRACTPMID:38522982 | DOI:10.1016/j.asjsur.2024.03.064 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 24, 2024 Category: Surgery Authors: Hongyu Wang Jinbao Wang Jianping Yu Xiaopeng Han Source Type: research

FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway
In this study, we found that after cisplatin treatment, the apoptosis of granulosa cells increased in a concentration-dependent manner, accompanied by the downregulation of FTO and YAP1. Furthermore, overexpression of FTO decreased cisplatin-induced granulosa cell apoptosis, inhibited the Hippo/YAP kinase cascade-induced phosphorylation of YAP1, and promoted the entry of YAP1 into the nucleus. The downstream targets of YAP1 (CTGF, CYR61, and ANKRD1) were also increased. Si-RNA-mediated downregulation of FTO promoted cisplatin-induced granulosa cell apoptosis, activated the Hippo/YAP kinase cascade, and inhibited the YAP1 e...
Source: Cell Research - March 16, 2024 Category: Cytology Authors: Rongli Wang Feiyan Cheng Xinyuan Yang Source Type: research

Metformin mitigates cisplatin-induced ovarian damage through inhibiting the pyroptosis of granulosa cells via ROS/TXNIP/NLRP3 signaling pathway
Aging (Albany NY). 2024 Mar 14;16. doi: 10.18632/aging.205659. Online ahead of print.ABSTRACTCisplatin, a vital chemotherapy drug for solid malignant tumors, can detrimentally affect ovarian health and fertility in premenopausal patients with cancer. Currently, effective strategies to mitigate cisplatin-induced ovarian damage remain limited. Several studies have highlighted the potential of metformin as an anticancer agent with anti-aging properties and other health benefits. Hence, the present study established an animal model to investigate the impact of metformin on cisplatin-induced ovarian damage, elucidating its mech...
Source: Aging - March 14, 2024 Category: Biomedical Science Authors: Bo Wang Jian Li Qianyu Zhang Yuting Li Wu Ren Du He Source Type: research

Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research

Cancers, Vol. 16, Pages 1140: Follicle-Stimulating Hormone Receptor Expression and Its Potential Application for Theranostics in Subtypes of Ovarian Tumors: A Systematic Review
P. Zweemer Ovarian cancer mortality rates have not decreased significantly in the past years. As most women are still diagnosed in an advanced stage, there is a need for new treatment strategies for recurrent disease. A potentially new developing targeted approach, theranostics, combines diagnostics and treatment using radiopharmaceuticals. Through target receptors, imaging and treatment of malignant tissue can be achieved. For ovarian malignancy, the follicle-stimulating hormone (FSH) receptor may serve as a possible target since expression appears to be limited to ovarian cells. In this systematic review, we aim to ...
Source: Cancers - March 13, 2024 Category: Cancer & Oncology Authors: Marie-Christine E. Bakker Geertruid J. Brink Alex J. Poot Arthur J. A. T. Braat Geertruida N. Jonges Ronald P. Zweemer Tags: Systematic Review Source Type: research