Sex Cord-Stromal Tumors of the Ovary
Radiol Clin North Am. 2023 Jul;61(4):595-608. doi: 10.1016/j.rcl.2023.02.005. Epub 2023 Mar 31.ABSTRACTOvarian sex cord-stromal tumors (OSCSTs) are a rare group of ovarian neoplasms that can be benign or malignant. They are classified into pure sex cord tumors, pure stromal tumors, and mixed SCST. The most common malignant OSCSTs are adult granulosa cell tumors. In contrast to the more common ovarian epithelial malignancies, OSCSTs present in younger patients, often at early stages, with better prognoses. Imaging features are variable, and pathology is required for diagnosis. However, certain tumors demonstrate characteris...
Source: Radiologic Clinics of North America - May 11, 2023 Category: Radiology Authors: Madeleine Sertic Kyle M Devins Esther Oliva Susanna I Lee Aoife Kilcoyne Source Type: research
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study aimed to explore the effects of NPs on female reproduction using human ovarian granulosa cells (GCs) and female mice. The accumulation of polystyrene NPs (PS-NPs) in human granulosa-like tumor cells (KGN cells) and the ovaries of female Balb/c mice were evaluated by exposure to fluorescent PS-NPs. Proliferation and apoptosis, reactive oxygen species (ROS), and Hippo signaling pathway-related factors were analyzed in KGN cells. In addition, fertility rate, litter size, ovarian weight and microstructure, follicle development, serum level of anti-Mullerian hormone, and apoptosis in ovaries were examined in female m...
Source: Ecotoxicology and Environmental Safety - April 21, 2023 Category: Environmental Health Authors: Lianjie Zeng Chong Zhou Wenqing Xu Yupei Huang Wencan Wang Zhangqiang Ma Jian Huang Jia Li Liaoliao Hu Yue Xue Tao Luo Liping Zheng Source Type: research
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study aimed to explore the effects of NPs on female reproduction using human ovarian granulosa cells (GCs) and female mice. The accumulation of polystyrene NPs (PS-NPs) in human granulosa-like tumor cells (KGN cells) and the ovaries of female Balb/c mice were evaluated by exposure to fluorescent PS-NPs. Proliferation and apoptosis, reactive oxygen species (ROS), and Hippo signaling pathway-related factors were analyzed in KGN cells. In addition, fertility rate, litter size, ovarian weight and microstructure, follicle development, serum level of anti-Mullerian hormone, and apoptosis in ovaries were examined in female m...
Source: Ecotoxicology and Environmental Safety - April 21, 2023 Category: Environmental Health Authors: Lianjie Zeng Chong Zhou Wenqing Xu Yupei Huang Wencan Wang Zhangqiang Ma Jian Huang Jia Li Liaoliao Hu Yue Xue Tao Luo Liping Zheng Source Type: research
ER β in granulosa cell tumors and its clinical potential
Endocrinology. 2023 Apr 19:bqad063. doi: 10.1210/endocr/bqad063. Online ahead of print.ABSTRACTGranulosa cell tumors (GCT) are rare ovarian tumors that are comprised of an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCT, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCT which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCT...
Source: Endocrinology - April 19, 2023 Category: Endocrinology Authors: Madeleine Birgersson Rajitha Indukuri Per Antonson Ivan Nalvarte Amena Archer Cecilia Williams Source Type: research
ER β in granulosa cell tumors and its clinical potential
Endocrinology. 2023 Apr 19:bqad063. doi: 10.1210/endocr/bqad063. Online ahead of print.ABSTRACTGranulosa cell tumors (GCT) are rare ovarian tumors that are comprised of an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCT, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCT which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCT...
Source: Endocrinology - April 19, 2023 Category: Endocrinology Authors: Madeleine Birgersson Rajitha Indukuri Per Antonson Ivan Nalvarte Amena Archer Cecilia Williams Source Type: research
Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors
The objective of this study was to characterize the tumor microenvironment (TME) of primary and recurrent aGCTs and to identify correlates of disease recurrence. Total RNA sequencing (RNA-seq) was performed on 24 pathologically confirmed, cryopreserved aGCT samples, including 8 primary and 16 recurrent tumors. After read alignment and quality-control filtering, DESeq2 was used to identify differentially expressed genes (DEG) between primary and recurrent tumors. Functional enrichment pathway analysis and gene set enrichment analysis was performed using "clusterProfiler" and "GSVA" R packages. TME composition was investigat...
Source: Cancer Control - April 17, 2023 Category: Cancer & Oncology Authors: Eleonora Khlebus Veena K Vuttaradhi Thomas Welte Namrata Khurana Joseph Celestino Hannah C Beird Curtis Gumbs Latasha Little Alejandra Flores Legarreta Bryan M Fellman Tri Nguyen Barrett Lawson Sammy Ferri-Borgogno Samuel C Mok Russell R Broaddus David M Source Type: research
Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors
The objective of this study was to characterize the tumor microenvironment (TME) of primary and recurrent aGCTs and to identify correlates of disease recurrence. Total RNA sequencing (RNA-seq) was performed on 24 pathologically confirmed, cryopreserved aGCT samples, including 8 primary and 16 recurrent tumors. After read alignment and quality-control filtering, DESeq2 was used to identify differentially expressed genes (DEG) between primary and recurrent tumors. Functional enrichment pathway analysis and gene set enrichment analysis was performed using "clusterProfiler" and "GSVA" R packages. TME composition was investigat...
Source: Cell Research - April 17, 2023 Category: Cytology Authors: Eleonora Khlebus Veena K Vuttaradhi Thomas Welte Namrata Khurana Joseph Celestino Hannah C Beird Curtis Gumbs Latasha Little Alejandra Flores Legarreta Bryan M Fellman Tri Nguyen Barrett Lawson Sammy Ferri-Borgogno Samuel C Mok Russell R Broaddus David M Source Type: research
Diagnostic yield and safety of ultrasound-guided percutaneous testicular biopsies in children
ConclusionUltrasound-guided testicular biopsy can be performed safely in children as an alternative to open surgical biopsy, with a high diagnostic yield and low complication rate.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 13, 2023 Category: Radiology Source Type: research
Clinical characteristics and oncological outcomes of recurrent adult granulosa cell tumor of ovary: A retrospective study of seventy patients
ConclusionsThe recurrence pattern in patients with recurrent adult granulosa cell tumor was characterized as late and repeated, multifocal, and distant relapse. It has been demonstrated that PFS1 ≤ 60 months and distant lesion at recurrence are independent risk factors for PFS-R, and PFS-R ≤ 33 months is an independent risk factor for OS-R. The PWP-CP model showed that the transabdominal approach and surgery reaching R0 could significantly decrease the recurrence frequency. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - April 4, 2023 Category: OBGYN Authors: Yu Gu,
Dan Wang,
Congwei Jia,
Lihua Chen,
Wei Cang,
Xirun Wan,
Junjun Yang,
Yang Xiang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
A rare case of primary retroperitoneal extraovarian granulosa cell tumor
We present a case of an extraovarian tumor in an elderly female who presented with lump in the abdomen occupying the pelvic region. She was operated and the mass was excised with intact capsule. Histopathology revealed the mass to be an adult granulosa cell tumor. Extraovarian granulosa cell tumors are very rare with only 13 such cases reported in literature to date. The present case is the largest primary retroperitoneal adult granulosa cell tumor reported till date. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - April 3, 2023 Category: Internal Medicine Authors: A Menon L Singla SG Pujari CV Kantharia Source Type: research
Sex Cord-Stromal Tumors of the Ovary
Ovarian sex cord-stromal tumors (OSCSTs) are a rare group of ovarian neoplasms that can be benign or malignant. They are classified into pure sex cord tumors, pure stromal tumors, and mixed SCST. The most common malignant OSCSTs are adult granulosa cell tumors. In contrast to the more common ovarian epithelial malignancies, OSCSTs present in younger patients, often at early stages, with better prognoses. Imaging features are variable, and pathology is required for diagnosis. However, certain tumors demonstrate characteristic imaging appearances that can be useful in narrowing the differential diagnosis. (Source: Radiologic...
Source: Radiologic Clinics of North America - March 31, 2023 Category: Radiology Authors: Madeleine Sertic, Kyle M. Devins, Esther Oliva, Susanna I. Lee, Aoife Kilcoyne Source Type: research
Unusual presentation of adult granulosa cell tumor. A case report and review of the literature
We report a new and rare case of an extraovarian adult granulosa cell tumor occurring in a 66-year-old woman who was presented with severe abdominal pain focused on the left iliac fossa. The immunohistopathology confirmed the diagnosis of a paratubal adult granulosa cell tumor. This paper illustrates the histogenetic origin of granulosa cell tumor, its clinicopathological and immunohistochemical features. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - March 30, 2023 Category: Cancer & Oncology Source Type: research
Granulosa cell tumor of ovary with abdominal wall metastasis: A case report
Asian J Surg. 2023 Mar 17:S1015-9584(23)00269-5. doi: 10.1016/j.asjsur.2023.02.096. Online ahead of print.NO ABSTRACTPMID:36935285 | DOI:10.1016/j.asjsur.2023.02.096 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 19, 2023 Category: Surgery Authors: Lin Wang Ya-Hui Chen Ya-Nan Wang Lin Sun Source Type: research
Granulosa cell tumor of ovary with abdominal wall metastasis: A case report
Asian J Surg. 2023 Mar 17:S1015-9584(23)00269-5. doi: 10.1016/j.asjsur.2023.02.096. Online ahead of print.NO ABSTRACTPMID:36935285 | DOI:10.1016/j.asjsur.2023.02.096 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 19, 2023 Category: Surgery Authors: Lin Wang Ya-Hui Chen Ya-Nan Wang Lin Sun Source Type: research
AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures
CONCLUSIONS: Androgen-producing cystic granulosa cell tumor is rare gynecological disorders, which need both gynecologic oncological and endocrinological approach. Its clinical manifestations may bring some clues to the pathogenesis of ovulatory dysfunctions, such as polycystic ovary syndrome.PMID:36922845 | DOI:10.1186/s13048-023-01134-0 (Source: Cell Research)
Source: Cell Research - March 16, 2023 Category: Cytology Authors: Michio Kitajima Itsuki Kajimura Yuriko Kitajima Naoko Murakami Asako Matsumura Kanako Matsumoto Ayumi Harada Yuri Hasegawa Kiyonori Miura Source Type: research
