Serum granulosa cell-derived TNF- α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling
In this study, we investigated the mediators responsible for PCOS-related kidney injury. We found that tumor necrosis factor (TNF-α) levels were significantly increased in serum and primary cultured granulosa cells (GCs) from PCOS patients. Serum TNF-α levels were positively correlated with serum testosterone and luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio, suggesting its positive role in the severity of PCOS. Serum TNF-α levels were also positively correlated with the levels of urinary KapU, LamU, α1-MU and β2-MU, the markers for renal tubular cell-derived proteinuria. We established a PCOS mous...
Source: Acta Pharmacologica Sinica - July 28, 2023 Category: Drugs & Pharmacology Authors: Hui-Yun Ye Ya-Li Song Wen-Ting Ye Chong-Xiang Xiong Jie-Mei Li Jin-Hua Miao Wei-Wei Shen Xiao-Long Li Li-Li Zhou Source Type: research
Serum granulosa cell-derived TNF- α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling
In this study, we investigated the mediators responsible for PCOS-related kidney injury. We found that tumor necrosis factor (TNF-α) levels were significantly increased in serum and primary cultured granulosa cells (GCs) from PCOS patients. Serum TNF-α levels were positively correlated with serum testosterone and luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio, suggesting its positive role in the severity of PCOS. Serum TNF-α levels were also positively correlated with the levels of urinary KapU, LamU, α1-MU and β2-MU, the markers for renal tubular cell-derived proteinuria. We established a PCOS mous...
Source: Acta Pharmacologica Sinica - July 28, 2023 Category: Drugs & Pharmacology Authors: Hui-Yun Ye Ya-Li Song Wen-Ting Ye Chong-Xiang Xiong Jie-Mei Li Jin-Hua Miao Wei-Wei Shen Xiao-Long Li Li-Li Zhou Source Type: research
Serum granulosa cell-derived TNF- α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling
In this study, we investigated the mediators responsible for PCOS-related kidney injury. We found that tumor necrosis factor (TNF-α) levels were significantly increased in serum and primary cultured granulosa cells (GCs) from PCOS patients. Serum TNF-α levels were positively correlated with serum testosterone and luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio, suggesting its positive role in the severity of PCOS. Serum TNF-α levels were also positively correlated with the levels of urinary KapU, LamU, α1-MU and β2-MU, the markers for renal tubular cell-derived proteinuria. We established a PCOS mous...
Source: Acta Pharmacologica Sinica - July 28, 2023 Category: Drugs & Pharmacology Authors: Hui-Yun Ye Ya-Li Song Wen-Ting Ye Chong-Xiang Xiong Jie-Mei Li Jin-Hua Miao Wei-Wei Shen Xiao-Long Li Li-Li Zhou Source Type: research
Serum granulosa cell-derived TNF- α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling
In this study, we investigated the mediators responsible for PCOS-related kidney injury. We found that tumor necrosis factor (TNF-α) levels were significantly increased in serum and primary cultured granulosa cells (GCs) from PCOS patients. Serum TNF-α levels were positively correlated with serum testosterone and luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio, suggesting its positive role in the severity of PCOS. Serum TNF-α levels were also positively correlated with the levels of urinary KapU, LamU, α1-MU and β2-MU, the markers for renal tubular cell-derived proteinuria. We established a PCOS mous...
Source: Acta Pharmacologica Sinica - July 28, 2023 Category: Drugs & Pharmacology Authors: Hui-Yun Ye Ya-Li Song Wen-Ting Ye Chong-Xiang Xiong Jie-Mei Li Jin-Hua Miao Wei-Wei Shen Xiao-Long Li Li-Li Zhou Source Type: research
Clinicopathological analysis of patients with molecularly confirmed stage I adult granulosa cell tumors and prediction of recurrence
CONCLUSIONS: The type of primary surgical procedure, ERα score, and Ki-67 index are independent predictors of recurrence for patients with stage I AGCT. Our predictive model based on these factors showed good performance.PMID:37481922 | DOI:10.1016/j.ygyno.2023.07.007 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 23, 2023 Category: Cancer & Oncology Authors: Yilin Liu Jingci Chen Zhaohui Lu Xiaoyan Chang Pengyan Wang Heng Ma Xianlong Chen Shengwei Mo Zhuoyao Lv Xinxin Mao Liju Zong Shuangni Yu Jie Chen Source Type: research
Clinicopathological analysis of patients with molecularly confirmed stage I adult granulosa cell tumors and prediction of recurrence
CONCLUSIONS: The type of primary surgical procedure, ERα score, and Ki-67 index are independent predictors of recurrence for patients with stage I AGCT. Our predictive model based on these factors showed good performance.PMID:37481922 | DOI:10.1016/j.ygyno.2023.07.007 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 23, 2023 Category: Cancer & Oncology Authors: Yilin Liu Jingci Chen Zhaohui Lu Xiaoyan Chang Pengyan Wang Heng Ma Xianlong Chen Shengwei Mo Zhuoyao Lv Xinxin Mao Liju Zong Shuangni Yu Jie Chen Source Type: research
Clinicopathological analysis of patients with molecularly confirmed stage I adult granulosa cell tumors and prediction of recurrence
CONCLUSIONS: The type of primary surgical procedure, ERα score, and Ki-67 index are independent predictors of recurrence for patients with stage I AGCT. Our predictive model based on these factors showed good performance.PMID:37481922 | DOI:10.1016/j.ygyno.2023.07.007 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 23, 2023 Category: Cancer & Oncology Authors: Yilin Liu Jingci Chen Zhaohui Lu Xiaoyan Chang Pengyan Wang Heng Ma Xianlong Chen Shengwei Mo Zhuoyao Lv Xinxin Mao Liju Zong Shuangni Yu Jie Chen Source Type: research
Clinicopathological analysis of patients with molecularly confirmed stage I adult granulosa cell tumors and prediction of recurrence
CONCLUSIONS: The type of primary surgical procedure, ERα score, and Ki-67 index are independent predictors of recurrence for patients with stage I AGCT. Our predictive model based on these factors showed good performance.PMID:37481922 | DOI:10.1016/j.ygyno.2023.07.007 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 23, 2023 Category: Cancer & Oncology Authors: Yilin Liu Jingci Chen Zhaohui Lu Xiaoyan Chang Pengyan Wang Heng Ma Xianlong Chen Shengwei Mo Zhuoyao Lv Xinxin Mao Liju Zong Shuangni Yu Jie Chen Source Type: research
Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of asparagus against polycystic ovary syndrome
CONCLUSION: The therapeutic effect of ASP on PCOS is mainly achieved by targeting PRKCA through the 7 active components of ASP. Mechanistically, ASP alleviated the course of PCOS through antioxidant, anti-inflammatory effects, and PRKCA was its potential target.PMID:37393270 | DOI:10.1186/s13048-023-01210-5 (Source: Cell Research)
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Jinshan Xing Xin Luo Keran Jia Shuang Liu Shaokun Chen Gan Qiao Chunxiang Zhang Jingyan Yi Source Type: research
Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of asparagus against polycystic ovary syndrome
CONCLUSION: The therapeutic effect of ASP on PCOS is mainly achieved by targeting PRKCA through the 7 active components of ASP. Mechanistically, ASP alleviated the course of PCOS through antioxidant, anti-inflammatory effects, and PRKCA was its potential target.PMID:37393270 | PMC:PMC10315040 | DOI:10.1186/s13048-023-01210-5 (Source: Cell Research)
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Jinshan Xing Xin Luo Keran Jia Shuang Liu Shaokun Chen Gan Qiao Chunxiang Zhang Jingyan Yi Source Type: research
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03
ConclusionKetoconazole has shown activity in advanced GCT in clinical and in vitro studies. Based on these data, an orphan designation was granted by the European Medicines Agency for ketoconazole in GCT (EU/3/17/1857).ClinicalTrials.gov IdentifierNCT01584297. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 25, 2023 Category: Cancer & Oncology Source Type: research
Atypical Presentation of Granulosa Cell Tumor in an Adolescent: A Case Report
: Granulosa cell tumors (GCTs) frequently present with elevated levels of estrogen and inhibin. Most diagnoses in the pediatric and adolescent population are juvenile-type GCTs; adult-type GCTs in this population are rare. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - June 22, 2023 Category: OBGYN Authors: Aimee Morrison, Joseph G. Pressey, Katherine VandenHeuvel, Tara Streich-Tilles Source Type: research
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03
ConclusionKetoconazole has shown activity in advanced GCT in clinical and in vitro studies. Based on these data, an orphan designation was granted by the European Medicines Agency for ketoconazole in GCT (EU/3/17/1857).ClinicalTrials.gov IdentifierNCT01584297. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 8, 2023 Category: Cancer & Oncology Source Type: research
Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis
We present two unrelated patients suspected to have DICER1 syndrome. Both females (aged 13 and 15 years) presented with multinodular goiter (thyroid follicular nodular disease) and ovarian tumours. One was diagnosed with an ovarian Sertoli-Leydig cell tumour (SLCT) and the other, with an ovarian juvenile granulosa cell tumour, later reclassified as a retiform variant of SLCT. Genetic screening showed no germline pathogenic variants inDICER1. However, two potentially splicing variants were found,DICER1 c.5365-4A>G and c.5527+3A>G. Also, typical somaticDICER1 RNase IIIb hotspot mutations were detected in the thyroid ...
Source: Familial Cancer - May 30, 2023 Category: Cancer & Oncology Source Type: research
Ovarian juvenile granulosa cell tumors with Ollier ’s disease in children with IDH1 gene somatic mutation
Conclusion: The incidence of ovarian juvenile granulosa cell tumors with Ollier’s disease in children may be caused by generalized mesodermal dysplasia, IDH1 gene mutation may play a facilitated role in this process. Surgical operation is the main treatment. We suggest that patients with ovarian juvenile granulosa cell tumors and Ollier’s disease should undergo regular investigation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - May 30, 2023 Category: Endocrinology Source Type: research
