Ovarian juvenile granulosa cell tumors with Ollier ’s disease in children with IDH1 gene somatic mutation

Conclusion: The incidence of ovarian juvenile granulosa cell tumors with Ollier’s disease in children may be caused by generalized mesodermal dysplasia, IDH1 gene mutation may play a facilitated role in this process. Surgical operation is the main treatment. We suggest that patients with ovarian juvenile granulosa cell tumors and Ollier’s disease should undergo regular investigation.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research