The Effects of Evening Primrose/Hemp Seed Oil Compared to Rapamycin on the Gene Expression of Immunological Parameters in Experimental Autoimmune Encephalomyelitis Splenocytes.
In conclusion, the EP/HS oil is likely to be involved in transcription of factors in favor of EAE improvement as well as participating in remyelination in the EAE spinal cord and that it suggests to be effective in therapeutic approaches for MS.
PMID: 32372631 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - April 15, 2020 Category: Allergy & Immunology Authors: Rezapour-Firouzi S, Mohammadian M, Sadeghzadeh M, Mehranfar S, Mazloomi E Tags: Iran J Allergy Asthma Immunol Source Type: research
Impact of evening primrose oil consumption on psychological symptoms of postmenopausal women: a randomized double-blinded placebo-controlled clinical trial
Objective:
The purpose of this study was to determine the efficacy and safety of evening primrose oil on women's psychological symptoms during menopause.
Methods:
A double-blinded randomized placebo-controlled trial carried out from September 2018 to February 2019 in Bandar Abbas, Iran. Eligible women randomly received either 1,000 mg of evening primrose oil capsules daily or matching placebo for 8 weeks. The Main outcome measures were psychological symptoms based on the psychological subscale of the Menopause Rating Scale. Independent samples t test was used for intergroup comparisons and paired samples t test for ...
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research
Evening Primrose Oil Ameliorates Hyperleptinemia and Reproductive Hormone Disturbances in Obese Female Rats: Impact on Estrus Cyclicity
Obesity is a public health burden disturbing all body functions and reproductive hormones. As obesity increases among females, there will be a rising challenge to physicians in care from fertility problems. Evening primrose oil (EPR oil) contains essential fatty acids including omega-6 linoleic acid with strong anti-inflammatory activity. Since EPR oil has utility in alleviating dysmenorrhea, this study aimed to ascertain its modulatory effect on systemic inflammation, reproductive hormones and estrus cycle irregularity in female obese rats. Thirty-two female rats were distributed to 4 groups: (i) normal, (ii) dietary obes...
Source: Frontiers in Endocrinology - January 29, 2020 Category: Endocrinology Source Type: research
Flaxseed and evening primrose oil slightly affect systolic and diastolic function of isolated heart in male but not in female rats.
Authors: Andjic M, Draginic N, Radoman K, Jeremic J, Turnic TN, Srejovic I, Zivkovic V, Kovacevic M, Bolevich S, Jakovljevic V
Abstract
Considering that sex related differences in cardiac response to flaxseed (FSO) and evening primrose oil (EPO) are insufficiently known present investigation assessed the effect of these two oils, on the cardiac function of isolated rat hearts and the possible role of sex in this. The present study was carried out on 60 adult male Wistar albino rats randomly divided into 6 groups: male rats treated with EPO, dose of 10 mg/kg/day; female rats treated with EPO, dose of 10 ...
Source: International Journal for Vitamin and Nutrition Research - November 10, 2019 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
An investigation into the effect of evening primrose in dilatation of cervix and pain during and after hysterosalpingography.
Authors: Nia SS, Safi F, Shoukrpour M, Kamali A
Abstract
Hysterosalpingography is one of the essential diagnostic methods for examining women who have difficulty becoming pregnant. This procedure is somehow invasive and is associated with numerous complications such as allergic sensitivity, pain, abdominal cramps and shock. Therefore, this study aimed to investigate the effect of evening primrose on cervical length and pain during and after hysterosalpingography. In this double-blind clinical trial, 66 candidates for hysterosalpingography were randomly divided into two groups. A group received 1000 mg of e...
Source: Journal of Medicine and Life - November 1, 2019 Category: General Medicine Tags: J Med Life Source Type: research
Chain length of dietary fatty acids determines gastrointestinal motility and visceromotor function in mice in a fatty acid binding protein 4-dependent manner
ConclusionModifying dietary intake of MCFAs and LCFAs may be used to control GI motility or visceral pain and thus modulate the symptoms of functional GI disorders. The effect is dependent on the expression of FABP4. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - September 26, 2019 Category: Nutrition Source Type: research
In Situ Hi-C for Plants: An Improved Method to Detect Long-Range Chromatin Interactions.
Abstract
Recently, long noncoding RNAs (lncRNAs) are shown to be implicating nuclear domain organization and gene regulation by mediating long-range chromatin interactions. Chromosome conformation capture (3C) is a method used to study such long-range interaction between two different loci in the 3D nuclear space. Through successive improvement in resolution and throughput, 3C, chromosome conformation capture on chip (4C), and chromosome conformation capture carbon copy (5C) to Hi-C methods were developed to study interactions between loci from one versus one scale to an unprecedented genome-wide resolutio...
Source: Mol Biol Cell - August 4, 2019 Category: Molecular Biology Authors: Padmarasu S, Himmelbach A, Mascher M, Stein N Tags: Methods Mol Biol Source Type: research
Molecules, Vol. 24, Pages 2709: Screening and Isolating Major Aldose Reductase Inhibitors from the Seeds of Evening Primrose (Oenothera biennis)
ongyuan Yan
Aldose reductase (AR) is a drug target for therapies to treat complications caused by diabetes mellitus, and the development of effective AR inhibitors (ARIs) of natural origin is considered to be an attractive option for reducing these complications. In this research, the rat lens AR (RLAR) inhibitory activity of evening primrose (Oenothera biennis) seeds was investigated for the first time. In our results, the 50% (v/v) methanol extract of evening primrose seeds exhibits excellent RLAR inhibitory activity (IC50 value of 7.53 μg/mL). Moreover, after enrichment of its bioactive components, the AR...
Source: Molecules - July 24, 2019 Category: Chemistry Authors: Zhiqiang Wang Shigang Shen Ze Cui Hailiang Nie Dandan Han Hongyuan Yan Tags: Communication Source Type: research
A validated capillary electrophoresis method for fatty acid determination in encapsulated vegetable oils supplements
Publication date: Available online 11 July 2019Source: LWTAuthor(s): Tatiane Lima Amorim, Lucas Mattos Duarte, Paula Rocha Chellini, Marcone Augusto Leal de OliveiraAbstractOmega 3, 6 and 9 fatty acids (FA), functional components of vegetable oils, are proved to be beneficial to health. For this reason, several oils are being used as food supplements. This work describes a validated method for FA determination in vegetable oils supplements containing palmitic, stearic, oleic, linoleic and α-linolenic FA employing capillary electrophoresis and a straightforward sample preparation. Avocado, carthamus, evening primrose and l...
Source: LWT Food Science and Technology - July 12, 2019 Category: Food Science Source Type: research
Influence of omega fatty acids on skin permeation of a coenzyme Q10 nanoemulsion cream formulation: characterization, in silico and ex vivo determination.
Conclusion: CoQ10 loaded-linseed oil nanoemulsion cream displayed the highest skin permeation. The highest permeation showed by linseed oil nanoemulsion cream may be due to the presence of omega-3, -6, and -9 fatty acids which might serve as permeation enhancers. This indicated that the edible oil nanoemulsion creams have potential as drug vehicles that enhance CoQ10 delivery across skin.
PMID: 31216907 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - June 22, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Influence of different supplementation on platelet aggregation in patients with rheumatoid arthritis
ConclusionsCo-administration of supplementation-concentrated fish oil may reduce platelet aggregation in adults with RA.Key Points• Omega-3 PUFAs are essential for health and are known to possess anti-inflammatory properties, improving cardiovascular health as well as benefiting inflammatory diseases..• In this paper, we report on anti-aggregation effects n-3 PUFAs and ɤ-linolenic acid in RA.• The risk of cardiovascular morbidity and mortality is increased in RA, and dietary supplementation of n-3 PUFA may have preventive potential for the cardiovascular management in rheumatoid arthritis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - May 9, 2019 Category: Rheumatology Source Type: research
Random Forest as One-Class Classifier and Infrared Spectroscopy for Food Adulteration Detection
Publication date: Available online 27 April 2019Source: Food ChemistryAuthor(s): Felipe Bachion de Santana, Waldomiro Borges Neto, Ronei J. PoppiAbstractThis paper proposes the use of random forest for adulteration detection purposes, combining the random forest algorithm with the artificial generation of outliers from the authentic samples. This proposal was applied in two food adulteration studies: evening primrose oils using ATR-FTIR spectroscopy and ground nutmeg using NIR diffuse reflectance spectroscopy. The primrose oil was adulterated with soybean, corn and sunflower oils, and the model was validated using these ad...
Source: Food Chemistry - April 27, 2019 Category: Food Science Source Type: research
Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis.
Abstract
We investigated the effects of Oenothera biennis L. and Hypericum perforatum L. extracts on brain tissue histopathology, myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in mice with experimental autoimmune encephalomyelitis (EAE). Forty-seven C57BL/6J mice were divided into the following groups: multiple sclerosis (MS), control (healthy mice), MS + H. perforatum treated (MS + HP), MS + O. biennis treated (MS + OB). All groups except the control group were immunized by EAE meth...
Source: Biotechnic and Histochemistry - April 7, 2019 Category: Research Authors: Selek S, Esrefoglu M, Meral I, Bulut H, Caglar HG, Sonuc G, Yildiz C, Teloglu ES, Dogan N, Yuce B, Tiftik E, Bayindir N Tags: Biotech Histochem Source Type: research
