Co-Processed Crystalline Solids of Ivermectin with Span < sup > ® < /sup > 60 as Solubility Enhancers of Ivermectin in Natural Oils
In this study, polymorphic and co-crystal screening was used to see if such solid-state modifications can improve the oil solubility of ivermectin. Span® 60, a lipophilic non-ionic surfactant, was chosen as co-former. The rationale behind attempting to improve oil solubility was to use ivermectin in future topical and transdermal preparations to treat a range of skin conditions like scabies and head lice. Physical mixtures were also prepared in the same molar ratios as the co-crystal candidates, to serve as controls. Solid-state characterization was performed using X-ray powder diffraction (XRPD), Fourier-transform infrar...
Source: AAPS PharmSciTech - March 23, 2024 Category: Drugs & Pharmacology Authors: Luandri de Vos Minja Gerber Wilna Liebenberg Johanna C Wessels Hendrik J R Lemmer Source Type: research
Co-Processed Crystalline Solids of Ivermectin with Span < sup > ® < /sup > 60 as Solubility Enhancers of Ivermectin in Natural Oils
In this study, polymorphic and co-crystal screening was used to see if such solid-state modifications can improve the oil solubility of ivermectin. Span® 60, a lipophilic non-ionic surfactant, was chosen as co-former. The rationale behind attempting to improve oil solubility was to use ivermectin in future topical and transdermal preparations to treat a range of skin conditions like scabies and head lice. Physical mixtures were also prepared in the same molar ratios as the co-crystal candidates, to serve as controls. Solid-state characterization was performed using X-ray powder diffraction (XRPD), Fourier-transform infrar...
Source: AAPS PharmSciTech - March 23, 2024 Category: Drugs & Pharmacology Authors: Luandri de Vos Minja Gerber Wilna Liebenberg Johanna C Wessels Hendrik J R Lemmer Source Type: research
Co-Processed Crystalline Solids of Ivermectin with Span < sup > ® < /sup > 60 as Solubility Enhancers of Ivermectin in Natural Oils
In this study, polymorphic and co-crystal screening was used to see if such solid-state modifications can improve the oil solubility of ivermectin. Span® 60, a lipophilic non-ionic surfactant, was chosen as co-former. The rationale behind attempting to improve oil solubility was to use ivermectin in future topical and transdermal preparations to treat a range of skin conditions like scabies and head lice. Physical mixtures were also prepared in the same molar ratios as the co-crystal candidates, to serve as controls. Solid-state characterization was performed using X-ray powder diffraction (XRPD), Fourier-transform infrar...
Source: AAPS PharmSciTech - March 23, 2024 Category: Drugs & Pharmacology Authors: Luandri de Vos Minja Gerber Wilna Liebenberg Johanna C Wessels Hendrik J R Lemmer Source Type: research
Co-Processed Crystalline Solids of Ivermectin with Span < sup > ® < /sup > 60 as Solubility Enhancers of Ivermectin in Natural Oils
In this study, polymorphic and co-crystal screening was used to see if such solid-state modifications can improve the oil solubility of ivermectin. Span® 60, a lipophilic non-ionic surfactant, was chosen as co-former. The rationale behind attempting to improve oil solubility was to use ivermectin in future topical and transdermal preparations to treat a range of skin conditions like scabies and head lice. Physical mixtures were also prepared in the same molar ratios as the co-crystal candidates, to serve as controls. Solid-state characterization was performed using X-ray powder diffraction (XRPD), Fourier-transform infrar...
Source: AAPS PharmSciTech - March 23, 2024 Category: Drugs & Pharmacology Authors: Luandri de Vos Minja Gerber Wilna Liebenberg Johanna C Wessels Hendrik J R Lemmer Source Type: research
The effect of Oenothera biennis (Evening primrose) oil on inflammatory diseases: a systematic review of clinical trials
Evening primrose oil (EPO), extracted from the seeds of Oenothera biennis, has gained attention for its therapeutic effects in various inflammatory conditions. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 15, 2024 Category: Complementary Medicine Authors: Melika Sharifi, Nasim Nourani, Sarvin Sanaie and Sanaz Hamedeyazdan Tags: Research Source Type: research
Olfaction in the Anthropocene: NO3 negatively affects floral scent and nocturnal pollination | Science
Nitrate radicals degrade floral scents enough to reduce evening primrose pollination by hawkmoths. (Source: Science: Current Issue)
Source: Science: Current Issue - February 8, 2024 Category: Science Source Type: research
Evening primrose oil enriched with gamma linolenic acid and D/L-alpha tocopherol acetate attenuated carbon tetrachloride-induced hepatic injury model in male rats via TNF- α, IL-1β, and IL-6 pathway
. (Source: Toxicology Mechanisms and Methods)
Source: Toxicology Mechanisms and Methods - January 3, 2024 Category: Toxicology Authors: Heba Nageh Gad EL-HakSafaa M. KishkHeba M. A. Abdelrazeka Zoology Department, Faculty of Sciences, Suez Canal University, Ismailia, Egyptb Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egyptc Department of Physio Source Type: research
Assessing evening primrose oil effects on the serum levels of omentin-1 and biochemical parameters in the diabetic rat model
In this study, the influence of evening primrose oil on the serum levels of omentin-1 and some of biochemical parameters in the diabetic rat model were investigated. In total, 24 healthy Wistar Albino male rats with a weight range of 200 –250 g were classified into 4 groups of 6: First group: control normal, second group: EPO (evening primrose oil), third group: diabetic, fourth group: diabetic+EPO. After 20 days, serum samples were taken, and the required parameters were measured and analyzed. ELISA was utilized to determining serum omentin-1 levels. Also, the levels of biochemical factors TG, CHOL, HDL, LDL, FBS, and...
Source: Comparative Clinical Pathology - November 29, 2023 Category: Pathology Source Type: research
A phylogeny of the evening primrose family (Onagraceae) using a target enrichment approach with 303 nuclear loci
The evening primrose family (Onagraceae) includes 664 species (803 taxa) with a center of diversity in the Americas, especially western North America. Ongoing research in Onagraceae includes exploring striking... (Source: BMC Evolutionary Biology)
Source: BMC Evolutionary Biology - November 17, 2023 Category: Molecular Biology Authors: Rick P. Overson, Matthew G. Johnson, Lindsey L. Bechen, Sylvia P. Kinosian, Norman A. Douglas, Jeremie B. Fant, Peter C. Hoch, Rachel A. Levin, Michael J. Moore, Robert A. Raguso, Warren L. Wagner, Krissa A. Skogen and Norman J. Wickett Tags: Research Source Type: research
Cancers, Vol. 15, Pages 5003: Evening Primrose Extract Modulates TYMS Expression via SP1 Transcription Factor in Malignant Pleural Mesothelioma
Conclusion: EPE components reduced TYMS expression by occupation of SP1 motifs on the tyms promoter and reversed the EMT phenotype of invasive MPM cells. Further in-depth analysis of the molecular docking of polyphenol compounds with SP1 regulatory motifs is required. (Source: Cancers)
Source: Cancers - October 16, 2023 Category: Cancer & Oncology Authors: Ma łgorzata Chmielewska-Kassassir Katarzyna Sobierajska Wojciech M. Ciszewski Jakub Kryczka Andrzej Zieleniak Lucyna A. Wozniak Tags: Article Source Type: research
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9
CONCLUSIONS: The nutritional product Exelvit Menopause® significantly reduced menopausal symptoms.PMID:37750646 | DOI:10.26355/eurrev_202309_33578 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - September 26, 2023 Category: Drugs & Pharmacology Authors: S Palacios C Mustata J M Rizo P A Regidor Source Type: research
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9
CONCLUSIONS: The nutritional product Exelvit Menopause® significantly reduced menopausal symptoms.PMID:37750646 | DOI:10.26355/eurrev_202309_33578 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: S Palacios C Mustata J M Rizo P A Regidor Source Type: research
