Assessing evening primrose oil effects on the serum levels of omentin-1 and biochemical parameters in the diabetic rat model

In this study, the influence of evening primrose oil on the serum levels of omentin-1 and some of biochemical parameters in the diabetic rat model were investigated. In total, 24 healthy Wistar Albino male rats with a weight range of 200 –250 g were classified into 4 groups of 6: First group: control normal, second group: EPO (evening primrose oil), third group: diabetic, fourth group: diabetic+EPO. After 20 days, serum samples were taken, and the required parameters were measured and analyzed. ELISA was utilized to determining serum omentin-1 levels. Also, the levels of biochemical factors TG, CHOL, HDL, LDL, FBS, and liver enzymes ALP, GGT, ALT, AST, and LDH were measured. There was a significant decrease in serum concentrations of omentin-1 in diabetic rats in comparison with the normal control group and EPO group. Afte r using EPO, serum levels of omentin-1 increased in the diabetic+EPO group in comparison with the diabetic control group. Moreover, FBS and TG, ALP, ALT, and GGT were increased in diabetic rats. After using EPO, the levels of these parameters decreased significantly in the diabetic+EPO group compare d to the diabetic control group. Based on the results, it can be concluded that EPO can be a potential supplement to control diabetes and reduce blood sugar and diabetes-induced complications.Graphical abstract
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research